Cardiac Electromechanical Activity Flashcards

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1
Q

What is the major ion controlling cardiac resting membrane potential?

A

EC K+

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2
Q

What ion interaction is responsible for the cardiac action potential?

A
  • Ca entering cell via L-type channels
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3
Q

How do catecholamines affect excitation-contraction coupling?

A
  • Increase Ca Movement into cell by phosphorylation of sarcolemma calcium channels via cAMP-dependent protein kinase
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4
Q

What is the affect of cardiac glycosides?

A
  • Raise IC Na+ w/ effect of increasing contractile force
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5
Q

What is the affect of calcium antagonists?

A

prevents calcium from entering

the cell, decreasing contractile force.

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6
Q

Compare PKA vs Phosphlambin.

A
  • PKA Phosphorylates Ca channels in sarcolemma + causes inc entry Ca into cell + Contraction
  • Phospholambin: phosphorylated by PKA to facilitate relaxation
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7
Q

Differentiate hyperdynamic and hypodynamic heart.

A

Hyperdynamic: Reduced EDP, Fast rising VP, brief EF

Hypodynamic: Elevated EDP; Slow rise VP; Reduced EF

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8
Q

What does the slope do the ascending limb of VP curve?

A

Maximal rate of force by ventricle

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9
Q

How do Ionotropic affect Frank-Starling?

A

INC Inotrophy —> Shifts right

DEC Inotrophy —> Shifts left

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