neuroendocrine disorders

Question 1

MEN 1

Answer 1

pituitary, parathyroid, pancreas
3 Ps
- MEN1 gene mutation (tumor suppressor gene) menin protein
- might see Congo red stain

Question 2

MEN 2a

Answer 2

parathyroid, medullary thyroid carcinoma, pheocromocytoma
2 p’s
RET receptor tyrosine kinase mutation

Question 3

MEN 2b

Answer 3

pheochromocytoma, medullary thyroid carcinoma, mucosal neuromas (orał/GI gangnlioneuromas), marfanoid habitus
-RET receptor tyrosine kinase mutation

Question 4

Neurofibromatosis

Answer 4

• mutation of NF1 gene on chromosome 17
• cafe au lait spots, neurofibromas (almost look like cystic acnes), Lisch nodules (iris hamartomas), bony abnormalities, other associated tumors: meningioma, astrocytoma, glioma, pheochromocytoma

Question 5

medullary thyroid cancer

Answer 5

nests of polygonal cells with Congo red staining