heme uworld Flashcards
1
Q
treat factor V
A
fresh frozen plasma
2
Q
immune thrombocytopenia purpura
A
caused by circulating antibodies against platelets that leads to thrombocytopenia, normal PT and PTT
3
Q
____ time should be monitored with patients on warfarin
A
prothrombin
4
Q
warfarin inhibits factors
A
II, VII, IX, X, protein C and S
5
Q
_____ time measures unfractionated heparin
A
aPTT
6
Q
haptoglobin levels ____ in hemolytic anemia
A
decrease
7
Q
MCV in hereditary spherocytosis
A
normal to low
8
Q
lactate dehydrogenase is ____ in hemolytic anemia
A
elevated
9
Q
pyruvte kinase deficiency
A
- autosomal recessive
- burr cells on peripheral blood smear
- intravascular hemolysis with negative osmotic fragility test
- pyruvate kinase assay positive
- increased 2,3 BPG causing right shift
- impairs glycolysis leading to ATP depletion
10
Q
inability to metabolizes fructose
A
hereditary fructose intolerance
11
Q
hereditary fructose intolerance
A
- defective aldolase B
- autosomal recessive
- accumulation of intracellular fructose 1 phosphate which causes inhibition of gluconeogenesis and glycocogenolysis
- lethary and seizure
Eye problems - after infants first ingest fruit, honey, or juice
- vomiting and hypoglycemia, jaundice
- eventual liver cirrhosis
- reducing sugar in urine but negative urine dipstick (because thats glucose only)
