Neuro Review- First Aid- pg 4-449 Flashcards

1
Q
  • support, repair
  • K+ metabolism
  • removal of excess NTs
  • help make BBB
  • GFAP marker
  • derived from neuroectoderm
  • reactive gliosis in response to neural injury
A

astrocytes

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2
Q

What makes myelin?

A
  • CNS = oligodendrocytes
  • PNS = Schwann cells
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3
Q

oligodendrocyte

A
  • myelinate axons in CNS- each one does many (30ish)
  • predominant in white matter
  • derived from neuroectoderm
  • “fried egg” on H and E stain
  • injured in MS, PML, and leukodystrophies
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4
Q
  • myelinate axons in CNS- each one does many (30ish)
  • predominant in white matter
  • derived from neuroectoderm
  • “fried egg” on H and E stain
  • injured in MS, PML, and leukodystrophies
A

oligodendrocyte

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5
Q

Dx?

  • type of scwannoma
  • CN VIII (8)
  • bilateral = neurofibromatosis type 2
A

acoustic neuroma

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6
Q

CNs of taste?

A

VII, IX, X (7, 9, 10- solitary nucleus)

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7
Q
  • for pain and temp
  • C = slow, unmyelinated
  • Adelta = fast, myelinated
A

free nerve endings

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8
Q

CN of motor to tongue?

A

XII (12)

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9
Q
  • large
  • myelinated
  • adapt quickly
  • deep skin layers, ligaments, joints
  • vibration/pressure
A

Pacinian corpuscles

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10
Q
  • large
  • myelinated
  • adapt slowly
  • pressure/deep static touch/position sense
A

Merkel discs

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11
Q

Each Schwann cell myelinates ____.

A

1 PNS axon

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12
Q

syringomyelia

A
  • cystic cavity in spinal cord
  • damages commissural fibers first
  • “cape-like” bilateral loss of pain and temp sensation in upper extremities
  • most common C8-T1
  • Chiari 1 malformation
  • HAs and cerebellar symptoms
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13
Q

What destroys Schwann cells?

A

Guillain-Barre syndrome

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14
Q

Merkel discs

A
  • large
  • myelinated
  • adapt slowly
  • pressure/deep static touch/position sense
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15
Q

Guillain-Barre syndrome

A

autoimmune Schwann cell destruction

rapid onset muscle weakness, sensory abnormalities in distal extremities

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16
Q

degeneration distal to the injury and axonal retraction proximally –> potential PNS axon regeneration

A

Wallerian degeneration

17
Q

Where do Schwann cells derive from?

A

neural crest cells

18
Q

Meissner corpuscles

A
  • large
  • unmyelinated
  • adapt quickly
  • hairless skin
  • fine touch/position
19
Q

Wallerian degeneration

A

degeneration distal to the injury and axonal retraction proximally –> potential PNS axon regeneration

20
Q

Pacinian corpuscles

A
  • large
  • myelinated
  • adapt quickly
  • deep skin layers, ligaments, joints
  • vibration/pressure
21
Q

astrocytes

A
  • support, repair
  • K+ metabolism
  • removal of excess NTs
  • help make BBB
  • GFAP marker
  • derived from neuroectoderm
  • reactive gliosis in response to neural injury
22
Q

Dx?

  • cystic cavity in spinal cord
  • damages commissural fibers first
  • “cape-like” bilateral loss of pain and temp sensation in upper extremities
  • most common C8-T1
  • Chiari 1 malformation
  • HAs and cerebellar symptoms
A

syringomyelia

23
Q
  • CNS phagocytes
  • mesodermal origin
  • small, irregular nuclei and little cytoplasm
  • part of mononuclear phagocyte system
  • HIV infected fuse –> giant CNS cells
A

microglia

24
Q

free nerve endings

A
  • for pain and temp
  • C = slow, unmyelinated
  • Adelta = fast, myelinated
25
Q

acoustic neuroma

A
  • type of scwannoma
  • CN VIII (8)
  • bilateral = neurofibromatosis type 2
26
Q
  • large
  • unmyelinated
  • adapt quickly
  • hairless skin
  • fine touch/position
A

Meissner corpuscles

27
Q

microglia

A
  • CNS phagocytes
  • mesodermal origin
  • small, irregular nuclei and little cytoplasm
  • part of mononuclear phagocyte system
  • HIV infected fuse –> giant CNS cells