Neuro: ANS Flashcards

1
Q

What is the control center of the ANS?

A

Hypothalamus

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2
Q

where does preganglionic neurons of SNS originate? where does it synapse to?

A

thoracolumbar spinal cord; synapses with sympathetic ganglia

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3
Q

mechanoreceptors where are pressure receptors founded? Stretch receptors?

A

pressure: aortic baroreceptors, carotid sinuses, lungs
stretch: veins, bladder, intestines

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4
Q

where are O2 found?

A

carotid and aortic bodies

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5
Q

where are H and CO2 found?

A

medulla

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6
Q

where are blood glucose and electrolytes found

A

hypothalamus

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7
Q

where are chemoreceptors also present?

A

stomach, taste buds, olfactory bulbs

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8
Q

responsive to things that damage tissue in arterial walls and viscera (stretch, ishcemia, chemicals)

A

nociceptors

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9
Q

what receptors respond to minute changes in circulating blood temperature in hypothalamus?

A

thermoreceptors

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10
Q

what receptors respond to external temperature changes in skin

A

thermoreceptors

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11
Q

where does preganglionic neurons of parasympathetics originate and synapse to?

A

brainstem and sacral spinal cord; synapses with parasympathetic ganglia (ganglia outside of CNS)

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12
Q

Sympathetic NT

A

epinephrine and norepinephrine

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13
Q

PNS NT

A

Ach

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14
Q

The ANS projects to the sympathetic NS in ________ parasympathetic ganglia in the ________

A

T1-L2/L3

Brainstem and S2-S4

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15
Q

The Afferent components of the ANS carry sensory information from _______ to the CNS

A

Organs/tissues

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16
Q

How does the ANS infleunce cardiopulm function

A

Regulates rate and depth of respiration

Regulates the diameter of bronchial lumen

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17
Q

Blood glucose and electrolytes are monitored where?

A

IN hypothalamus

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18
Q

Stretch receptors are found in the ___________

pressure receptors are found in the ________

A

Veins, bladder, intenstines

Aorta, carotid sinus, lungs

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19
Q

What are 4 kinds of receptors that the ANS uses?

A

Mechanoreceptors

chemoreceptors

nociceptors

thermoreceptors

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20
Q

information from visceral receptors enter CNS via two routes: into the

A
  1. SC via dorsal roots
  2. brainstem via cranial nerves (7.9.10)
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21
Q

most visceral info coming into the BS via the cranial nerves converges in the _____ nucleus (the main visceral sensory nucleus). from there it relays to visceral control areas in the ____ and _____. and modulatory areas in the hypothalamus, thalamus, and limbic system

A

solitary; pons and medulla

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22
Q

afferent autonomic info is processed in the?

A

solitary nucleus, SC, areas of BS, hypothalamus, and thalamus

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23
Q

How does the ANS regulate homeostasis

A

-Cardiopulm

-metabolism

-regulate body temp

-regulate autonomic responses

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24
Q

Visceral Nociceptive afferents connect with somatic efferents to cause __________

A

Muscle guarding in skeletal muscles

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25
Q

What is the fx of the solitary nucleus

A

viseral input (CN 7, 9, 10) converges onto solitary nucleus in medulla. (synapse point)

ANS afferents

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26
Q

Afferents of the ANS enter the CNS through what part of the spinal cord?

A

Dorsal Root

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27
Q

What is the area of the brainstem that controls vitals?

A

reticular formation - complex neural network that extends vertically throughout the brainstem

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28
Q

The medulla regulates vitals through autonomic efferents and the ____

A

Vagus N

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29
Q

The Medulla regulates what vitals?

Pons?

A

Medulla- HR, Respiration, Vasoconstrict/dilation

Pons- Only respiration

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30
Q

Most visceral input to the thalamus is through the ________ to the cerebral cortex areas

A

Limbic system (emotional/motivational system)

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31
Q

Visceral information reaching the hypothalamus us used to ______. They hypothalamus does this through…

A

maintain equilibrium in the interior of the body (cardiorespiratory, metabolic, water resorption, digestive activity)

hypothalamus does this via acting on pituitary gland, control centers in brainstem and SC

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32
Q

Whats the role of the thalamus/hypothalamus/limbic system in the ANS?

A

Modulate autonomic brainstem control

(think, medulla and pons control, while hypothalamus, thalamus and limbic modulate!)

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33
Q

all preganglionic neurons in ANS release ____ (NT) and bind to what receptors?

A

release Ach which binds to nicotinic receptors on the post-ganglionic neuron

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34
Q

postganglionic neurons in PNS release ___ (NT) which binds to what receptors?

A

releases Ach which binds to muscarinic receptors on target tissues

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35
Q

most sympathetic postganglionic neurons release ____ (NT) which binds to what receptors?

A

release norepinephrine, which binds to adrenergic receptors (a and B receptors) on target organ

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36
Q

neurons that release ach are called

neurons that release norepi or epi are called

A

ach = cholinergic

norepi and epi = adrenergic

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37
Q

Norepinephrine is found inside of ___________

Whereas epinephrine is only found ____________

A

Most sympathetic postganglionic neurons

Only in andrenal medulla

38
Q

parkinsons is degermation of dopamine-producing neurons in the substantia nigra, leading to a dopamine deficiency in the basal ganglia. what are the motor symptoms associated?

A

TRAP

tremors, rigidity, akinesia (bradykinesia), postural instability

**NOTE - it will also impair cognition, mood and emotions, sleep, sensory and ANS dysfxn and hyposmia

39
Q

What is the enteric nervous system?

A

Lies within the gut for peristalsis and GI secretions

40
Q

Neurons from CNS to ganglion are preganglionic, also called

Neurons from Ganglion to effector organ are called postganglionic, AKA

A

A-beta fibers

C fibers

41
Q

Somatic efferent pathways use ______ neuron(s) in the peripheral system and autonomic efferent pathways have ______ neuron(s) with synapse outside the CNS

42
Q

Preganglionic neurons of the sympathetic NS have cell bodies where?

A

Inside of the lateral horn in T1-L2/3

(note: they exit through ventral nerve root to spinal nerve)

43
Q

where are the postganglionic SNS cell bodies?

A

paravertebral ganglion

44
Q

Which type of fibers travel farther? Pre-ganglionic or post-ganglionic

A

Post ganglionic

45
Q

Where is there a 1 neuron connection within the sympathetic nervous system?

A

1 neuron connection directly to adrenal medulla

the rest use 2 neurons

46
Q

Difference between mid/thoracic and upper lumbar vs. the upper thoracic SNS?

A

Midthoracic and upper lumbar nerves travel through the sympathetic trunk

upper thoracic nerves synapse inside of sympathetic trunk

47
Q

SNS tracts to the periphery and thoracic viscera synapse where?

A

Paravertebral ganglia (sympathetic trunk)

48
Q

SNS tracts to the pelvic/abdominal organs synapse where?

A

prevertebral ganglia (close to the organs)

49
Q

Sympathetic efferents to the head originate in the ________ and synapse in the ________

A

Hypothalamus

Upper T Spine

50
Q

What is the MAIN function of the SNS?

A

promote optimal circulation to organs

51
Q

Increases SNS activity _______ vessels, lessened SNS activity ________ vessels

A

constricts

dilates

52
Q

how does the SNS control body temp?

A

sweating
piloerection (goosebumps) to trap warm air
controls diameter of blood vessels in skinare more ventilated but dont get as much blood

53
Q

How does the SNS prepare for vigorous exercise?

A

vasodilation to active muscles

vasoconstriction to gut and skin

54
Q

How is the ANS important for a sit to stand?

A

Sympathetic nervous system constricts vessels to allow for adequate control of blood pressure and prevent orthostatic hypertension

55
Q

T or F: Parasympathetic NS dilates blood vessels

A

False, it doesn’t directly control blood vessel diameter, only the sympathetic NS does this.

56
Q

Which nervous system is fight or flight

which is rest and digest?

A

Symp- Fight or flight

Para - rest and digest

57
Q

Does the PNS have an interconnected ganglia chain like the sympathetic NS?

58
Q

Where are the 2 neuronal pathways of the PNS found?

A

Brainstem and Sacral cord.

59
Q

Which cranial nerves are associated with the parasympathetic NS?

A

3, 7 , 9, 10

Basically anything with eyelid, anything with swallowing

60
Q

Nucleus ambiguus is associated with what 2 cranial nerves?

61
Q

From the lateral horn of the sacral SC, the axons travel in the splanchnic nerves to ____________ and _______________

A

Bowel/Bladder and genitalia

62
Q

the parasympathetic nervous system ______ the pupils

the sympathetic nervous system ________ the pupils

A

constricts

dilates

63
Q

the parasympathetic nervous system _______ the airways

the sympathetic nervous system ________ the airways

A

constricts

dilates

64
Q

Which nervous system stimulates peristalsis?

A

Parasympathetic

65
Q

What are examples of bodily systems that receive a balanced input from sympathetic and parasympathetic

A

Thoracic/abdominal viscera + Bowel/bladder + pupil

66
Q

Sympathetic nervous system is not opposed in what systems? (Not countered by parasympathetic output)

A

Controlling effectors in limbs, face, bodywall, raising eye lid

67
Q

Where is parasympathetic NS acting unopposed?

A

Increasing the convexity of the eye

68
Q

Where is the breathing rhythm generator found?

A

Anterior medulla

Note: balances calm vs arousal

69
Q

What is the Locus Coeruleus for?

A

arousal, alertness, anxiety

70
Q

What can inhibit the locus coeruleus and decrease anxiety/arousal

A

slow breathing can allow subgroups of neurons from the breathing rhythm generator in the medulla to inhibit the LC

71
Q

During freezing in the fight or flight response, what is activated?

A

Both sympathetic and parasympathetic’

note: bradycardia, immobility, combined with heightened alertness to pepare for action

72
Q

What is the purpose of freezing (fight or flight)

A

to optimize perception of threat and select action

73
Q

During freezing, first the __________ recognizes the threat and sends info to the ________ and anterior medulla to stimulate ____________

A

amygdala

hypothalamus

sympathetic NS

note: this is only 1 part, the Amygdala also activates the parasymp through another pathway

74
Q

During freezing the amygdala activates the parasympathetic NS which communicates with the ________ causing ________ to reduce heart rate and inhibit medulla and skeletal muscle contractions

A

Midbrain

CN 10 (Vagus N)

75
Q

Once fight/flight starts _______ decreases and ___________ increases

A

parasymp

symp

76
Q

Horners syndrome

A

lesion of sympathetic pathway to face

ipsilateral ptosis (drooping eyelid)

miosis (pupil consrict)

Redness

Sweating

77
Q

What can cause horner syndrome?

A

Damage to preganglionic nerve in upper thoracic SC, superior cervical ganglion, or cervical sympathetic trunk

78
Q

horner syndrome can be a side effect due to what

A

stellate ganglion chemical block used to treat complex regional pain syndrome

79
Q

Peripheral nerve injuries can damage sympathetic efferents causing….

A

problems with circulation, temp control, sweating, causing skin changes

80
Q

Complete injuries in the ___________ impair B/B function and sexual function

81
Q

Autonomic dysreflexia is caused by injuries above what level?

A

T5/T6

note: life threatening condition

82
Q

What is autonomic dysreflexia?

A

Irritatant below level of lesion causes ascending sympathetic response that cannot be inhibited for balanced BP control.

heightened sympathetic response causes rapid BP increase

83
Q

With autonomic dysreflexia you have _____ blood pressure and _______ heart rate

A

increased BP

Decreased HR

84
Q

What should you do in the case of autonomic dysreflexia

A

Induce orthostatic hypotension (to reduce BP)

Check for irritant

call for help

85
Q

Brainstem injuries vs cerebral injuries

A

Brainstem - impaired efferent control of vitals, dysfunction of CN nucei (pupil, tears, saliva, control of viscera)

Cerebral injuries- Damage to hypothalamus interferes with homeostasis with metabolic and behavioral impairments

86
Q

Orthostatic hypotension definition

A

decrease of 20mmHG or 10mmHG diastolic during 1st 3 mins of upright posture

note: pooling of blood in lower limbs and abdomen causes decreased cardiac output and BP

87
Q

How can a SCI cause orthostatic hypotension

A

disruption of descending signals from medulla to sympatheitc preganglionic nerves prevents vasoconstriction

88
Q

autonomic degen disorders like ________ can cause orthostatic hypotension

A

parkinson’s

89
Q

How can peripheral neuropathies cause orthostatic hypotension

A

damage to peripheral nerves interupt signals from SC to effectors that go to blood vessels

90
Q

What is neural reflexive syncope

A

sympathetic overactivity caused by emotional distress, pain, pressure on carotid sinus causing strong heart contractions and activating CN10

medulla inhibits sympathetic nervous system to allow vasodilation and stimulates CN 10 to reduce HR (Vasovagal syncope)