Neuro Flashcards
Branchial Clefts are derived from
Ectoderm
Branchial Pouches are derived from
Endoderm
Branchial Arches are derived from
Mesoderm
1st Branchial Cleft produces
External auditory meatus
2-4 Branchial Clefts produce
temporary cervical sinuses
If the temporary cervical sinuses persists –>
Branchial Cleft cyst on the lateral neck (doesn’t move w/ swallowing)
What other cyst may be confused w/ a Branchial Cleft cyst?
Thyroglossal cyst (midline, moves w/ swallowing)
1st Branchial Pouch produces
middle ear cavity, eustachian tubes, mastoid air cells
2nd Branchial Pouch produces
epithelial lining of the tonsils
3rd Branchial Pouch produces
thyroid & inferior parathyroid glands
4th Branchial Pouch produces
superior parathyroid glands
DiGeorge Syndrome
failure of the 3 & 4 branchial pouches to develop –> absent thymus & parathyroid glands –> T-cell immunodeficiency & hypocalcemia
1st Branchial Arch produces what cartilage
Meckel’s cartilage: mandible, mandible ligament, malleus, incus
1st Branchial Arch produces what muscles
mm of mastication: masseter, medial/lateral pterygoids, temporalis, mylohyoid, Tensor tympani, Tensor veli palatini, ant. 2/3 of tongue
1st Branchial Arch produces what nerve
CN V2 & V3
Failure of Branchial Arch 1 cells to migrate
Treacher-Collins Syndrome
2nd Branchial Arch produces what cartilage
stapes, styloid process, stylohyoid ligament, lesser horn of hyoid
2nd Branchial Arch produces what muscles
mm. of facial expression: stapedius, stylohyoid
2nd Branchial Arch produces what nerve
CN 7
3rd Branchial Arch produces what muscle
stylopharyngeal m.
3rd Branchial Arch produces what nerve
glossopharyngeal n.
Failure of the 2nd Branchial Arch cells to migrate
Pharyngocutaneous Fistula
4-6 Branchial Arch produces what cartilage
Criocoid & Thyroid cartilages, & cartilage of the larynx
4-6 Branchial Arch produces what muscle
Cricothyroid, pharyngeal, laryngeal
4-6 Branchial Arch produces what nerve
CN 10
Prosencephalon develops into
telencephalon & diencephalon
Mesencephalon develops into
Midbrain
Rhombencephalon develops into
metencephalon & myelencephalon
Telencephalon develops into
Cerebral hemispheres
Diencephalon develops into
Thalamus
Metencephalon develops into
Cerebellum & pons
Myelencephalon develops into
Medulla
What week does the developing brain begin to form
week 4 - dilation
Anencephaly is increased risk w/
maternal diabetes
Holoprosencephaly is increased risk w/
Trisomy 13, FAS, SHH mutation (fx during weeks 5-6)
Dandy-Walker
Agenesis of the cerebellar vermis -> 4th ventricle/posterior fossa enlargement
Dandy-Walker is associated w/
spina bifida and hydrocephalus
Chiari I
mild cerebellar tonsil herniation through foramen magnum
Chiari I may cause
syringomyelia
Chiari II
significant cerebellar tonsils & vermis herniation through foramen magnum
Chiarir II is associated w/
lumbosacral myelomeningocele
Chiari II may cause
aqueductal stenosis & hydrocepahlus
Syringomyelia
cavitary lesion in the spine filled w/ CSF
Compresses STT spinal commissural fibers -> b/l loss of pain&temp in UEs (cape-like distribution)
Severe -> compress ant. horn motor neurons -> hand mm. weakness & atrophy
Most common location of Syringomyelia
C8-T1
Syringomyelia is associated w/
Chiari I
Reactive Gliosis
astrocytes form scar tissue in response to injury
Nissl Bodies
RER in neuronal dendrites
BBB
Non-fenestrated endothelial tight junctions
BM capillary
Astrocyte foot processes
Astrocyte marker
GFAP
Astrocyte tumor
Glioblastoma
CNS phagocytes
microglia
HIV infection in the CNS
microglia giant cell formation
Cell destroyed in Multiple sclerosis
Oligodendrocyte
“Fried egg” Appearance
Oligodendrocyte (large clear cytoplasm)
Myelin producing cell in the CNS
Oligodendrocyte
Myelin producing cell in the PNS
Schwann Cells
Acoustic Neuroma
Schwanoma in the internal acoustic meatus
B/L Acoustic Neuroma
Neurofibromatosis type II
Cell destroyed in Guillain-Barre
Schwann Cells
Microglia are derived from
Mesoderm
Oligodendrocytes are derived from
neuroectoderm
Astrocytes are derived from
neuroectoderm
What substances cross the BBB?
glucose & a.a. w/ transporter
non-polar, lipid-soluble
ADH & Oxytocin (fenestrated area)
Acute Tx for high ICP
Mannitol
Alzheimers Disease
Degeneration of basal nucleus of Meynert -> low Choline Acetyltransferase -> low ACh
Site of GABA production
Nucleus Accumbens
Site of ACh production
Raphe nucleus
Site of NE production
Locus ceruleus, reticular formation, solitary tract
Reticular Activation System components
Reticular formation, Locus ceruleus, Raphe nucleus
Gerstmann Lesion
lesion to dominant angular gyrus
lesion to dominant angular gyrus Sx
agraphia, acalculia, R/L disorientation, finger agnosia
Hemispatial neglect - lesion to the
non-dominant parietal lobe
Frontal lesion Sx
disinhibition, poor judgment, primitive reflexes
Prefrontal lesion Sx
inability to complete complex functions
Frontal Eye Field lesion
eyes deviate toward side of lesion
PPRF lesion
eyes deviate away from side of lesion
Superior Colliculus lesion
inability to gaze upward
Parinaud’s Syndrome
Superior Colliculus lesion
RAS Lesion
stupor & coma
B/L Hippocamous Lesion
Anterograde amnesia
Destruction of mammillary bodies is seen in what disorder
Wernicke-Korsakoff - thiamine deficiency
Destruction of mammillary bodies Sx
nystagmus, opthalmoplegia, ataxia, encephalopathy, anterograde & retrograde amnesia, confabulation
Poor repetition is seen with a lesion to
arcuate fasciculus
Poor comprehension is seen w/ a lesion to
Wernicke’s area
Poor verbal expression is seen w/ a lesion to
Broca’s area
Personality changes & disinhibition is seen w/ a lesion to
Frontal cortex
Dysarthria is seen w/ a lesion to
Cerebellar vermis
Kluver Bucy Syndrome
B/L amygdala lesion
Hemibalism is seen w/ a lesion to
the sub thalamic nucleus of the basal ganglia
Parkinson Sx may be seen w/ a lesion to
Basal ganglia
Expressive dysprosody is seen w/ a lesion to
inability to express emotion
Non-dominant Broca area
Receptive dysprosody is seen w/ a lesion to
inability to comprehend emotion
Non-dominant Wernicke’s area
Hemispheric cerebellar lession
Ipsilateral limb ataxia & intention tremors are seen w/ a lesion to
Cerebellar vermis lesion
affects midline structures -> truncal ataxia & dysarthria
Fracture to the cribiform plate is most likely to lesion
CN 1
Lesion to an optic n. would result in
Anopsia (blindness in effected eye)
Lesion to the optic chiasm (pituitary tumor)
bitemporal hemianopsia
Lesion to an optic tract
homonymous hemianopsia
Homonymous hemianopsia w/ macular sparing is likely to result from
PCA infarct (macula receives collateral circulation from the MCA)
Bilateral hemianopsia
lesion to the optic chiasm
Homonymous hemianopsia
lesion to the optic tract
Wallerian Degeneration
axonal injury resulting in degeneration distal to the injury& axonal retraction proximally
Each oligodendrocyte myelinates x number of axons
~30