Heme

Question 1

PT assesses

Answer 1

Extrinsic pathway + common pathway

Question 2

Extrinsic Pathway cascade

Answer 2

7—>10

Question 3

Intrinsic Pathway cascade

Answer 3

12, 11, 9, 8 —>10

Question 4

Common Pathway

Answer 4

10, 5, Thrombin, Fibrin

Question 5

Protein C & S

Answer 5

inhibit factors 5 & 8 (accelerators)

Question 6

Protein C & S deficiency

Answer 6

unable to inhibit 5 & 8 -> hypercoagulability

Question 7

Hemophilia A

Answer 7

deficient factor 8 -> macro hemorrhages (hemarthrosis, bruising)

Question 8

Hemophilia B

Answer 8

deficient factor 9 -> macro hemorrhages (hemarthrosis, bruising)

Question 9

Factor 5 Leiden

Answer 9

factor 5 resistant to Protein C & S inhibition

Question 10

Prothrombin G20210A mutation

Answer 10

thrombosis

Question 11

Antithrombin deficiency

Answer 11

unable to inactivate thrombin -> hypercoaguable state

Question 12

Factor 12 activates

Answer 12

factor 11 & kallikrein

Question 13

Kallikrein

Answer 13

activates plasmin & increases bradykinin production

Question 14

Plasmin

Answer 14

break down clot

Question 15

What lab tests is used the monitor anticoagulation in pt taking Heparin?

Answer 15

PTT

Question 16

What lab tests is used the monitor anticoagulation in pt taking Warfarin?

Answer 16

PT (INR)

Question 17

Basophilic stipling is seen w/

Answer 17

Lead Poisoning

Question 18

Burr cell is seen w/

Answer 18

uremia, renal failure

Question 19

Acanthocyte (spur cell) is seen w/

Answer 19

liver ds or abetalipoproteinemia

Question 20

Spherocytes are seen w/

Answer 20

Hereditary spherocytosis

Question 21

Schistocytes are seen w/

Answer 21

mechanical shearing (DIC, HIT, TTP)

Question 22

Target cells are seen w/

Answer 22

Thalassemia, Hb-C, Asplenics, Liver ds

Question 23

Howell-Jolly Body is seen in

Answer 23

Asplenics (nuclear remnant)

Question 24

Heinz Bodies are seen in

Answer 24

G6PD deficiency

Question 25

Bite cells are seen w/

Answer 25

G6PD deficiency

Question 26

Teardrop cells are seen w/

Answer 26

Myelofibrosis

Question 27

Eliptocytes are seen w/

Answer 27

Hereditary eliptocytosis

Question 28

Sideroblasts are seen w/

Answer 28

Heme synthesis disorders (drugs, EtOH, Myelodysplastic Sx)

Question 29

Erythroblastosis fetalis - Sx

Answer 29

anemia, RBC hemolysis, jaundice, kernicterus, hydrops fetalis, intrauterine death

Question 30

Most common lymphoma in US

Answer 30

Diffuse Large B-cell Lymphoma

Question 31

Most common non-Hodgkin Lymphoma in adults

Answer 31

Diffuse Large B-cell Lymphoma

Question 32

Most common non-Hodgkin Lymphoma in children

Answer 32

Lymphoblastic Lymphoma

Question 33

Reed-Sternberg Cells are seen in

Answer 33

Hodgkin Lymphoma

Question 34

Hodgkin Lymphoma prognosis is based on

Answer 34

Reed-Sternberg cell:Lymphocyte ratio | Low # RS cells w/ High # Lymphocytes is good

Question 35

Starry-sky appearance

Answer 35

Burkitt Lymphoma

Question 36

African child, EBV infection, mandible tumor

Answer 36

Endemic Burkitt Lymphoma

Question 37

Reed-Sternberg Cell histology

Answer 37

Large B cells w/ bilobed nuclei & prominent "owl's eye inclusions"

Question 38

Lymphoma assoc w/ Sjogrens, Hashimotos, & H. pylori

Answer 38

Marginal Cell MALToma

Question 39

Lymphoma assoc w/ non-infectious fever

Answer 39

Hodgkin Lymphoma

Question 40

Lymphoma assoc. w/ EBV

Answer 40

Burkitt Lymphoma, Hodgkin

Question 41

Lymphoma assoc. w/ long-term Celiac Disease

Answer 41

Intestinal T-cell Lymphoma

Question 42

Lymphoma assoc. w/ HTLV-1 virus

Answer 42

Adult T-cell Lymphoma

Question 43

Lymphoma equivalent to CLL

Answer 43

Small Lymphocytic Lymphoma

Question 44

Lymphoma assoc. w/ t(11, 14) & aberrant cyclin D

Answer 44

Mantle Cell Lymphoma

Question 45

Lymphoma assoc. w/ t(14, 18)

Answer 45

Diffuse Large B-cell & Follicular Lymphoma

Question 46

Sezary Syndrome

Answer 46

Mycosis Fungoides Lymphoma disseminated in blood