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DIT > Heme > Flashcards

Heme Flashcards

1
Q

PT assesses

A

Extrinsic pathway + common pathway

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2
Q

Extrinsic Pathway cascade

A

7—>10

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3
Q

Intrinsic Pathway cascade

A

12, 11, 9, 8 —>10

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4
Q

Common Pathway

A

10, 5, Thrombin, Fibrin

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5
Q

Protein C & S

A

inhibit factors 5 & 8 (accelerators)

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6
Q

Protein C & S deficiency

A

unable to inhibit 5 & 8 -> hypercoagulability

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7
Q

Hemophilia A

A

deficient factor 8 -> macro hemorrhages (hemarthrosis, bruising)

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8
Q

Hemophilia B

A

deficient factor 9 -> macro hemorrhages (hemarthrosis, bruising)

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9
Q

Factor 5 Leiden

A

factor 5 resistant to Protein C & S inhibition

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10
Q

Prothrombin G20210A mutation

A

thrombosis

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11
Q

Antithrombin deficiency

A

unable to inactivate thrombin -> hypercoaguable state

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12
Q

Factor 12 activates

A

factor 11 & kallikrein

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13
Q

Kallikrein

A

activates plasmin & increases bradykinin production

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14
Q

Plasmin

A

break down clot

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15
Q

What lab tests is used the monitor anticoagulation in pt taking Heparin?

A

PTT

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16
Q

What lab tests is used the monitor anticoagulation in pt taking Warfarin?

A

PT (INR)

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17
Q

Basophilic stipling is seen w/

A

Lead Poisoning

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18
Q

Burr cell is seen w/

A

uremia, renal failure

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19
Q

Acanthocyte (spur cell) is seen w/

A

liver ds or abetalipoproteinemia

20
Q

Spherocytes are seen w/

A

Hereditary spherocytosis

21
Q

Schistocytes are seen w/

A

mechanical shearing (DIC, HIT, TTP)

22
Q

Target cells are seen w/

A

Thalassemia, Hb-C, Asplenics, Liver ds

23
Q

Howell-Jolly Body is seen in

A

Asplenics (nuclear remnant)

24
Q

Heinz Bodies are seen in

A

G6PD deficiency

25
Q

Bite cells are seen w/

A

G6PD deficiency

26
Q

Teardrop cells are seen w/

A

Myelofibrosis

27
Q

Eliptocytes are seen w/

A

Hereditary eliptocytosis

28
Q

Sideroblasts are seen w/

A

Heme synthesis disorders (drugs, EtOH, Myelodysplastic Sx)

29
Q

Erythroblastosis fetalis - Sx

A

anemia, RBC hemolysis, jaundice, kernicterus, hydrops fetalis, intrauterine death

30
Q

Most common lymphoma in US

A

Diffuse Large B-cell Lymphoma

31
Q

Most common non-Hodgkin Lymphoma in adults

A

Diffuse Large B-cell Lymphoma

32
Q

Most common non-Hodgkin Lymphoma in children

A

Lymphoblastic Lymphoma

33
Q

Reed-Sternberg Cells are seen in

A

Hodgkin Lymphoma

34
Q

Hodgkin Lymphoma prognosis is based on

A

Reed-Sternberg cell:Lymphocyte ratio

Low # RS cells w/ High # Lymphocytes is good

35
Q

Starry-sky appearance

A

Burkitt Lymphoma

36
Q

African child, EBV infection, mandible tumor

A

Endemic Burkitt Lymphoma

37
Q

Reed-Sternberg Cell histology

A

Large B cells w/ bilobed nuclei & prominent “owl’s eye inclusions”

38
Q

Lymphoma assoc w/ Sjogrens, Hashimotos, & H. pylori

A

Marginal Cell MALToma

39
Q

Lymphoma assoc w/ non-infectious fever

A

Hodgkin Lymphoma

40
Q

Lymphoma assoc. w/ EBV

A

Burkitt Lymphoma, Hodgkin

41
Q

Lymphoma assoc. w/ long-term Celiac Disease

A

Intestinal T-cell Lymphoma

42
Q

Lymphoma assoc. w/ HTLV-1 virus

A

Adult T-cell Lymphoma

43
Q

Lymphoma equivalent to CLL

A

Small Lymphocytic Lymphoma

44
Q

Lymphoma assoc. w/ t(11, 14) & aberrant cyclin D

A

Mantle Cell Lymphoma

45
Q

Lymphoma assoc. w/ t(14, 18)

A

Diffuse Large B-cell & Follicular Lymphoma

46
Q

Sezary Syndrome

A

Mycosis Fungoides Lymphoma disseminated in blood

DIT (22 decks)

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