Nervous system Flashcards
Hydra (cnidarian)
neurons in nerve nets control the gastrovascular cavity
sea star (echinoderm)
Central nerve ring with radial nerves to each arm
cephalization
clustering of neurons in a brain near anterior (front) of animals with bilaterally symmetrical bodies
Planarian (flatworm)
small brain and longitduinal nerve cord define simplest CNS
Insects (arthropod)
brain+ventral nerve cord, segmental ganglion make PNS
Squid (upper molluscs)
brain+extensive ganglia
chordate
brain+dorsal spinal cord+sensory ganglion
dendrite
highly branched extensions that receive signals from other neurons
axon
transmits signals to other cells and may be over a meter long
astrocytes
in CNS, they provide structural support for neurons and regulate extracellular concentrations of ions and neurotransmitters
blood brain barrier
astrocytes induce tight junctions between cells that line capillaries in brain and spinal cord
radial glia
form tracks which newly formed neurons migrate from neural tube
oligodendrocytes
CNS glia that form myelin sheaths around axons with lipids like insulation
schwann cells
PNS glia that form myelin sheaths around axons with lipids like insulation
Na+ gradient
15mM cytosol; 150 mM extracelluar
K+ gradient
150 mM cytosol; 5mM extracellular
Cl- gradient
10mM cytosol; 120mM extracellular
ungated ion channels
resting potential is regulated by diffusion of K+ and Na+
ligand gated ion channels
found at synapses and open or close when neurotransmitter binds to channel
voltage gated ion channel
in axons, dendrites, cell bodies; open or close when membrane potential changes
hyperpolarization
increase in magnitude of membrane potential; inside becomes more negative and commonly caused by opening K+ channels
depolarization
inside of membrane becomes less negative due to opening Na+ channels
resting state gates
Na+: inactivation gate open-activation gate closed; K+: gate closed
depolarization gates
Na+: inactivation gate open-some activation gate open; K+: gate closed
rising action potential gate
Na+: inactivation-activation gate open; K+: gate closed
falling action potential gate
Na+: inactivation gate open-activation gate closed; K+: gate open
undershoot gate
Na+: inactivation-activation gate closed; K+: some gates open
refractory period
during undershoot no new action potential can occur
saltatory conduction
action potential moves from node of ranvier to node in myelin sheaths
node of ranvier
many voltage gated ion channels are present to transmit action potential to next segment
synaptic vesicles
presynaptic neuron synthesizes the neurotransmitter and is packaged here
presynaptic membrane-chemical
voltage gated Ca2+ goes into presynaptic terminal and causes synaptic vesicle fusion with presynaptic membrane
postsynaptic membrane-chemical
vesicles release neurotransmitter into synaptic cleft
synaptic cleft depolarization
action potential reaches synapse and triggers voltage gated Ca2+ channel
direct synaptic transmission
binds directly to receptor on ion channel that allows specific ions to diffuse across postsynaptic membrane
excitatory postsynaptic potential
neurotransmitter binds to Na+-K+ channel and membrane potential depolarizes so it is excitatory
inhibitory postsynaptic potential
neurotransmitter binds to K+ channel and membrane potential hyperpolarizes so it is inhibitory
temporal summation
EPSP happening closely together produces action potential
graded postsynaptic potential
since the postsynaptic cleft is at dendrite or cell body 1 EPSP is not able to produce action potential
spatial summation
EPSP produced by 2 different synapses can produce action potential
IPSP spatial summation
the addition of an IPSP and EPSP could lead to a blocked action potential
indirect synaptic transmission
neurotransmitter binds to a receptor that is not part of an ion channel, activating a signaling pathway
vertebrate neuromuscular junction
acetylcholine released by motor neurons binds to receptors on muscle cells and produces EPSP
biogenic amines
neurotransmitters derived from amino acids
catecholamines
derived from tyrosine: epinephrine, norepinephrine, and dopamine
serotonin
derived from tryptophan and released many brain sites
amino acid neurotransmitters
gamma aminobutyric acid, glycine, glutamate, aspartate
GABA
inhibitory neurotransmitter in brain by increasing permeability of postsynaptic membrane to Cl-
neuropeptides
relatively short peptide chains of amino acids-substance p and endorphins
opiates
morphine and heroin bind to endorphin receptors which block pain and emotional stress
gas neurotransmitters
carbon monoxide and nitric oxide
cranial nerves
originate in brain and terminate mostly in organs of head and upper body
spinal nerves
originate in spinal cord and extend to parts of body below the head
PNS components
somatic and autonomic nervous system
somatic nervous system
carries signals to and from skeletal muscles, in response to external stimuli
autonomic nervous system
regulates the internal environment by controlling smooth and cardiac muscles and digestive, endocrine, cardiovascular
sympathetic division
corresponds to arousal and energy generation
sympathetic action
dilates pupil of eye, relaxes bronchi of lung, inhibits pancreas, stimulates glucose release from liver, accelerates heart
parasympathetic division
promotes calming and return to self maintenance functions
parasympathetic action
constricts pupil of eye, stimulates activity of stomach, stimulates gall bladder, constrics bronchi of lungs
parasymp pregan neurotrans
acetylcholine
parasymp postgan neurotrans
acetylcholine
symp pregan neurotrans
acetylcholine
symp postgan neurotrans
norepinephrine
parasymp pregan neurons
brainstem and sacral segments of spinal cord
parasymp postgan neurons
ganglia close to target organs
symp pregan neurons
thoracic and lumbar segments of spinal cord
symp postgan neurons
some ganglia close to organs; some chain of ganglia near spinal cord
forebrain split 5 weeks
telencephalon and diencephalon
midbrain split 5 weeks
mesencephalon
hindbrain split 5 weeks
metencephalon and myelencephalon
telencephalon
cerebrum(cerebral cortext, white matter, basal nuclei)
diencephalon
thalamus, hypothalamus, epithalamus
mesencephalon
midbrain(part of brainstem)
metencephalon
pons(part of brainstem), cerebellum
myelencephalon
medulla oblongata(part of brainstem)
medulla oblongata
contains centers that control breathing, heart and blood vessel activity, swallowing, vomiting, digestion
pons
regulates the breathing centers in the medulla
reticular formation
90 separate clusters of neural cell bodies in core of brainstem that regulates sleep and arousal
serotonin
may be neurotransmitter for sleep and is synthesized from amino acid tryptophan
cerebellum
next to brainstem; coordination and error checking during motor, perceptual, cognitive functions. eg: hand eye coordination
epithalamus
diencephalon-includes pineal gland and choroid plexus,cluster of capillaries that produce cerebrospinal fluid from blood
thalamus
diencephalon- main input center for sensory info going to cerebrum and main output center for motor info leaving cerebrum
hypothalamus
diencephalon- source of posterior pituitary hormones and releasing hormones that act on anterior pituitary; hunger, pleasure center
mammal bio clock
pair of hypothalamic structures called the suprachiasmatic nuclei
basal nuclei
telencephalon- important centers for planning and learning movement sequences
neocortex
mammals have this region of cerebral cortex which is six layers of neurons on outermost part of cerebrum
cerebral cortex
telencephalon- sensory info analyzed, motor commands issued, language generated
corpus callosum
enables communication between right and left cerebral cortices
frontal lobe
speech and motor cortex
parietal lobe
behind frontal: somatosensory(touch, pain) cortex, speech, taste, reading
temporal lobe
lower lobe: auditory and smell
occipital lobe
back lobe: visual cortex
left hemisphere
language, math, logical operations; focused perception
right hemisphere
pattern recognition, spatial relation; emotion, music
broca’s area
frontal lobe: active during talking
wernicke’s area
temporal lobe: active during hearing and understanding speech
limbic system
emotions: 3 parts of cerebral cortex(amygdala, hippocampus, olfactory bulb)+some prefrontal cortex+sections hypothalamus and thalamus
amygdala
temporal lobe- central to recognizing facial emotional expressions
hippocampus
temporal lobe- explicit recall of events and long term memory
long term potentiation
increase in synaptic transmission strength that can last for days or weeks in vertebrate brain