Nerves, Neuroglia, and Spinal Cord Flashcards
What type of neuron are motor neurons usually?
multipolar
What type of neuron are in the retina and are sensory usually?
bipolar
What type of neuron are sensory neurons usually?
unipolar
Where are the cell bodies (soma) of the CNS located?
- gray matter cortex
- gray matter spinal cord
- nuclei
- centers
Where are the cell bodies (soma) of the PNS located?
Ganglia (except basal ganglia and ganglion layer of retina)
Where are the cell processes (axon/dendrites) of the CNS located?
- capsules
- tracts (round bundle)
- lemnisci (ribbon, flat)
- columns (parallel with crossover)
What are the support cells of CNS? And what is their embryonic origin?
- Astroglia, microglia, and oligodendroglia
2. neural tube
What are the support cells of PNS? And what is their embryonic origin?
- Schwann cells
2. neural crest
What are the six functions of astrocytes?
- Shape of CNS
- Maintain ionic homeostasis of interstitial space
- glutamate removal
- blood brain barrier
- gliosis (brain “scar”)
- astroglioma formation
What is the most common primary brain tumor and is benign?
astroglioma
Which neuroglial cells is involved in the immune system of the brain?
microglia
Which neuroglial cells make myelin for cranial nerves I and II?
oligodendrocytes
Which neuroglial cells make myelin for cranial nerves III through XII?
Schwann cells
What autoimmune disease that attacks oligodendrocyte-made myelin?
multiple sclerosis
What are the two types of multiple sclerosis?
- Relapsing Remitting
2. Primary progressive
Where are the locations of classic CNS plaques in patients that have MS?
- paraventricular
- juxtacortical
- infratentorial
- spinal cord
What is the bundle of CNS that connects CN III, IV, VI and the vestibular nuclei and is often affect by MS?
Medial Longitudinal Fasciculus (MLF)
What method is used to diagnose relapsing remitting MS?
MacDonald Criterion
What is the old MacDonald criterion to diagnose relapsing remitting MS? 1. What is the new criterion? 2.
- Two lesions disseminated in time and space
2. Two lesions disseminated in time and space with MRI showing non-contrasting old lesion vs contrastingnew
What type of MS is characterized by a fairly steady, gradual change in functional ability over time without any relapses?
Primary Progressive MS
What are the criterion to diagnose primary progressive MS?
- one year disease progression
AND - One of the following:
- typical MS lesion
- 2 or more lesions of similar type in spinal cord
- evidence in spinal fluid of oligoclonal band or elevated IgG index
What is the most common place for optic neuritis?
retrobulbar space
What does optic neuritis usually present as?
acute onset vision loss in central acuity (usually unilateral)
What is the affect of the pupil enlarging in the affected eye with a patient with optic neuritis called?
Afferent Pupillary Defect (APD)
What position of the eyes is the most painful for a patient with optic neuritis? 1. What is the effect on lights and color? 2
- up and in
2. dimmer
What cells line the ventricles and are the epithelial cells of the choroid plexus (making the CSF)?
ependymal cells
What nerves are Schwann cells on?
All peripheral nerves and CN III-XII
What is the name of the wrapping of the Schwann cell around the nerve?
neruolemma
What is the DICT vascular sheath that wraps around each nerve on top of endolemma?
epineurium
What are bundles of motor or sensory fibers within a nerve called?
fascicles