Neoplasia

Question 1

What are oncogenes

Answer 1

mutated genes whose products are associated with neoplastic transformation

Question 2

Appearance of Burkitts lymphoma and what can it be caused by

Answer 2

characterized by starry sky appearance

-caused by Epstein Barr virus and mc in children

Question 3

what is hodgkins lymphoma characterized by

Answer 3

Reed sternberg cells

Question 4

What is pheochromocytoma and what is it characterized by (s/S)

Answer 4

Adrenal medula tumor

-palpatations, perspiration and pressure headaches

Question 5

What is multiple myeloma and what is it characterized by

Answer 5

Characterized by malignant plasma cells in bone marrow

(m spike, bence jones proteins in urine)

Question 6

What is the mc primary bone cancer in children

Answer 6

osteosarcoma

Question 7

What is the mc benign smoith mm tumor in females

Answer 7

Uterine Leiomyoma

Question 8

What are the 4 types of leukemias and how to differentiate/who they mc in

Answer 8

acute lymphoblastic (ALL)- mc in children <5

Acute myelogenous (AML) mc in adults (Auer rods)

Chronic lymphocytic (CLL) >60 year old men)

Chronic Myelogenous (CML)- 30-60 years (Phillidephia chromosome)

Question 9

what is the genetic mutation responsible for lung cancer, breast cancer, melanoma

Answer 9

Lung- L-MYC
Breast- BRCA 1
Melanoma- p16

Question 10

what are the top 5 sites of metastasis in order of mc

Answer 10

lung
liver
bone
brain
adrenal gland

Question 11

Mc cancers in males

Answer 11

prostate (32), lung (16), colon/rectum (12)

Question 12

Mc cancers in remale

Answer 12

Breast (32). lung (16), colon/rectum (12)