MSK patho Flashcards
what is osteomalacia (why/signs on xray)
loss of bone quality with softening of the bones
-decreased vit d in adults
-loosers zones on the X-rays of one bones
what is rickets/who is it seen in (signs)
loss of bone quality
-decreased vit D in children
-bowlegs and rachitic rosary (swollen costochondral joss)
What is osteitis fibres cystica due to and signs
due to hyperparathyroidism
-brown bone cysts
What is chariots joint and what could it be due to (4)
Joint destruction because loss of pain
caused by
-Tabes dorsalis
-diabetes mellitus
-springomyelia
-leprosy
What is osteogenesis imperfecta
Autosomal dominant
-causes defective collagen synthesis
-blue sclera, brittle bone
What is osteomyelitis caused by (mc, sickle cell, Iv)
mc- staph A,
Sickle- Salmonella
Pseudomonas- IV
Giant cell tumor loc
benign metaphysical bone tumor extending into epiphyssis
Aneurysmal bone cyst
eccentric soap buckle xray appearance exiting from diaphysis into metaphysics
multiple myeloma (how common, age, s/s)
Mc primary bone cancer in adults
mc after 50
ss- nocturnal bone/back pain, recurrent inf, hyerpcalcemia, punched out lesions
Raised IgG causing M spike
Bence jones proteins in urine
What things will have positive RF
RA, SLE
What blood factors will u see in RA
RF +
HLA DR4+
What deformities will u see in RA
swan neck
ulnar dev
boutonnieres
Bouchards nodes
What is Feltys syndrome and what is it associated w
Associated w RA
-Splenomegaly
-neurtopenia
What blood markers will you see in SLE
ANA, Anti Ds-DNA
Who does SLE affect mc and s/s
young females (especially blacks)
-polyarthritis
-butterfly rash
-nephrotic syndrome
-libman-sacks endocarditis
What is sjogrens syndrome and who is it seen in
Dry eyes, dry out and arthritis
-may be seen in RA, Scleroderma
-mc in women bw 40-60
What is seen in the bloodwork of seronegative arthritis
RF negative
HLA B27+
What are the seronegative arthritis
Psoariactic, AS, Reiters syndrome
What is rieterrs syndrome (+ what else can it be caused by)
Urethritis
Arthritis
conjunctivitis
(may be caused by chlamydia/shigella)
what is gout caused by and what is it characterized by
due to hyperuricemia (may be associated with alcohol and purine-rich foods)
uric acid crystals are needle shaped an negatively burefringit with polarized light
What is lyme disease caused by and what is the presentation
borrelia burgdorferi
Polyarthritis with bulls-eye lesion
what does myasthenia gravis affect, mc affected, positive test
acetylecholine receptor antibodies
major peak- 30+ year old females, 60+ year old males
Tension test +
What does lambert eaton syndrome affect and effects of it
auto antibodies to pre synaptic voltage gated calcium channels (prevents each from being released)
-older male pop
-Tensilon test usually neg
What is dermatomyositis and what does it cause, what will u see on blood work
autoimmune disorder mc in females
-causes a heliotrope rash (reddish eyelids and papule on the knuckles of hands)
-Anti Jo-1 antibodies
What is charcot marie tooth disease and what happens
Progressive hereditary nerve damage
peroneal mm wating
What is legg-calve perches disease
ischemia and subsequent avascular necrosis of head of the femur
-mc in young boys
Slipped capital femoral epipythis and common pres
displacement of the epiphysis of head of the femur
-mc in young boys
What is poly myalgia rheumatica, mc pres/age, s/s
older females >50
pain and stiffness in shoulders and hips
-associated w temporal arthritis
-high elevated ESR
