NAPLEX Grouping Flashcards by Emily Jansen

Sulfa Allergy

Thiazides
Darunavir
Zonisamide
Bactrim
Fosamprenavir
Loops except ethacrynic acid
Celecoxib

“That Damn Zealous Bitch Forgot Lemon Cookies”

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Drugs that have a photosensitivity side effect

Bactrim
Thiazides/Loop
Fluoroquinolones
MTX
Doxycycline

“Bitch Thanks For My Dermatitis”

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Drugs that may cause DILE

Hydrazaline
Methyldopa
BiDil
Quinidine
Procainamide
Amiodarone
Minocycline

“Hello My Bitchy Queen P.A.M.”

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Drugs that decrease renal clearance of Lithium

Entresto
Salt intake
ACE-Is/ARBs
Diuretics

“Extra S.A.D.”

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Drugs that uses “actual body weight” for dosing

Insulins
Chemotherapy (actual BW for BSA)
Lovenox
UFH
Vancomycin

“I Can’t Love U Vic”

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Drugs that cause piapism

Sinemet
Trazodone
Stimulants
Lorcaserin
PDE-5 inhibitors

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Drugs that needs to be screened for HLA-B* 1502

Phenytoin
Fosphenytoin
Carbamazepine
Oxcarbazepine

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Smoking reduces the levels of these drugs:

Clozapine

Olanzapine

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Avoid taking these drugs at bedtime

Fluoxetine (activating)
Bupropion (activating)
Pseudoephedrine

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Drugs that discolor: Brown

Levodopa
Entacapone
Methyldopa

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Drugs that discolor: Brown/Black/Green

Methocarbamol

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Drugs that discolor: Purple/Orange/Red

Chlorzoxazone

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Drugs that discolor: Brown/Yellow

Metronidazole
Tinidazole, Nitrofurantoin
B2

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Drugs that discolor: Orange/Yellow

Sulfasalazine

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Drugs that discolor: Yellow-green

Propofol

Flutamide

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Drugs that discolor: Red-orange

Phenazopyridine
Rifapentine
Rifampin

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Drugs that discolor: Red

Anthracyclines

Deferasirox (urine)

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Drugs that discolor: Blue

Mitoxantrone

Methylene blue

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Drugs that discolor: Blue-gray

Chloroquine

Amiodarone

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Oncology - Take with food

Imatinib
Thalidomide
Capecitabine
Exemestane

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Oncology - Take on empty stomach

Nilotinib
Erlotinib
Sorafenib
Temozolomide
Abiraterone
Pomalidomide

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Oncology - Extravasation

Anthracyclines

IV promethazine

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Oncology - Drugs that cause neurotoxicity

Vincristine (Cr for cranium)
Taxanes
Cisplatin
Oxaliplatin (think of Olaf b/c of the cold sensitivity after chemo)

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Oncology - Drugs that cause QT prolongation

Ondansetron
Vemurafenib
Crizotinib

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Oncology - Drugs that cause alopecia

Vemurafenib Carboplatin Etoposide Doxorubicin

Oncology - Special consideration in administration

Vincas are fatal if given intrathecally (typically given central line) Anthracyclines need a central line due to extravasation b/c they're vesicants

Oncology - Chemotherapy that needs prophylaxis "buddy" Pemetrexed

B12 or folic acid for supplementation to lower levels of toxicity and dexamethasone to reduce rash

Oncology - Chemotherapy that needs prophylaxis "buddy" Taxanes

H1 & H2 blockers and corticosteroids to prevent infusion reactions

Oncology - Chemotherapy that needs prophylaxis "buddy" Immunotherapy agents

Corticosteroid to reduce immune related reactions

Oncology - Chemotherapy that needs prophylaxis "buddy" Pembrolizumab

Dexamethasone to prevent immune related reactions

Oncology - Chemotherapy that needs prophylaxis "buddy" Androgen Deprivation Therapy

Bisphosphonates (zoledronic acid or alendronate) for the bone SE + Ca and Vitamin D supplementation

Oncology - Chemotherapy that needs prophylaxis "buddy" Abiraterone

Prednisone to replace the cortisol

Oncology - Chemotherapy that needs prophylaxis "buddy" Docetaxel or Cabazitaxel (2nd line)

Prednisone for prostate cancer chemotherapy (standard of care)

Oncology - Major DDIs Antifolates that decrease clearance from body

Omeprazole

Oncology - Major DDIs Erlotinib

CYP3A4 Warfarin Omeprazole Ranitidine

Oncology - Major DDIs BCR-ABL inhibitors

CYP3A4 CYP2D6 Statins

Oncology - Major DDIs Tamoxifen with what and why?

Tamoxifen is metabolized by CYP3A4, CYP2C19, & CYP2D6 Interacts with fluoxetine & paroxetine

Oncology - Major DDIs Capecitabine

warfarin (increase INR)

Oncology - Major DDIs Enzalutamide

CYP3A4 CYP2C8 CYP2C9 CYP2C19

Oncology - Let's treat nausea Anticipatory

BZD | Olanzapine

Oncology - Let's treat nausea Acute

BZD, dexamethasone 5HT3 antagonists Cannabinoids Olanzapine

Oncology - Let's treat nausea Delayed

-prepitants Dexamethasone (most effective) Metoclopramide + dexamethasone

Oncology - Let's treat nausea Breakthrough Treatment

``` Phenothiazines (primarily) 5HT3 antagonists Metoclopramide Corticosteroids Dronabinol Olanzapine Lorazepam ```

Oncology - Let's treat diarrhea Normal diarrhea

Loperamide | Atropine/diphenoxylate (Lomotil)

Oncology - Let's treat diarrhea Irinotecan associated with early diarrhea

Atropine

Oncology - Let's treat diarrhea Irinotecan associated with late diarrhea

Loperamide (L for late)

Oncology - Let's treat constipation Name laxatives

Senna | Bisacodyl

Oncology - Let's treat constipation Name a Stool softener

Docusate sodium

Oncology - Let's treat constipation Name Osmotics

PEG | Lactulose

Oncology - Let's treat constipation Name a Prokinetic

Metoclopramide

Oncology - Let's treat constipation Name a Saline

Mg citrate for rescue

Oncology - Let's treat constipation Name an opioid receptor antagonist

Methylnaltrexone

Oncology - Let's treat constipation AVOID these agents

Bulk forming Suppositories Enemas

Oncology - Drugs that cause neuropathy

``` ~Oxaliplatin (DO NOT give to patient with DPN or > 70yoa) ~Bortezomib ~Carboplatin ~Paclitaxel (biggest problem) ~Cisplatin ```

Oncology - Drugs that have infusion reactions

Taxanes Rituximab Cetuximab

Oncology - Drugs that have hypersensitivity reactions

``` Alkylating agents Murine MoABs (-o) Trastuzumab Abiraterone Cabazitaxel (DO NOT use if pt had rxn to docetaxel) ```

Oncology - Drugs that cause constipation

Vincristine Vinblastine Cisplatin Thalidomide

Oncology - Let's treat acneiform rash!

Topical HC or Clindamycin Severe: Doxycycline or Minocycline AVOID: OTC acne meds like benzoyl peroxide

Oncology - Let's treat hypercalcemia! What is the regimen?

IV fluids: NS bolus & maintenance fluids PRN Bisphosphonates: Zoledronic acid and Pamidronate Calcitonin Denosumab: max 4 doses **D/c any Ca or phosphate supplements**

Oncology - Mnemonics Alkylating Agents & Anthracyclines work where in the cell cycle?

A for "any" phone of the cell cycle

Oncology - Mnemonics Carboplatin dose is calculated by what equation?

C for Calvert equation

Oncology - Mnemonics Oxaliplatin is exacerbated by what?

the cold "Olaf"

Oncology - Mnemonics Bevacizumab has what side effect?

B for Bleeding!!

Oncology - Mnemonics Always remember which agent has to be administered first before carboplatin?

Paclitaxel before carboplatin P for "prior"

Oncology - Mnemonics What is Erlotinib timing of administration?

E for "empty" stomach

Oncology - Mnemonics Equivalent dosing for 5HT3 antagonists:

"GOD" Granisetron 2 mg Ondansetron 24 mg Dolasetron 100 mg

Oncology - Mnemonics What is the most common cytotoxic treatments for breast cancer?

Remember "TATAs" Taxanes & Anthracyclines

Oncology - Mnemonics Interferon has no survival rate and causes flu-like symptoms

Interferon for inferior

What drugs should be avoided with alcohol?

Flagyl Warfarin Nilutamide Trokendi XR

What agents are NOT to be shaked?

ESAs Anti-TNF Biologic DMARDs for rheumatoid arthritis NTG TL spray Natalizumab

What agents need "time off" intervals?

Lidocaine patches (12 hrs) NTG (12-24 hrs) ACE & ARNI washout period is 36 hrs

What drugs are safe in pregnancy for HTN?

Labetalol Nifedipine Methyldopa

What antibiotics must be taken with a full glass of water?

``` Bactrim Fluoroquinolones Clindamycin doxycycline Minocycline ```

What antibiotics have to be separated from antacids?

Fluoroquinolones Nitrofurantoin Doxycycline

What antibiotics do NOT need to be refrigerated?

``` Cefdinir Clindamycin Azithromycin Ciprofloxacin Bactrim Clarithromycin Doxcycline ```

What antibiotics need to be taken with food?

``` Amoxicillin Augmentin Cefuroxime Flagyl IR Nitrofurantoin Clarithromycin ```

What antibiotics need to be taken before/after a meal?

``` Penicillin VK Azithromycin XR Flagyl IR Levofloxacin Doxycycline Minocycline ```

What antibiotics need to be refrigerated?

``` Amoxicillin Augmentin Cephalexin Cefuroxime Penicillin VK Erythromycin ```