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NAPLEX 2023 > NAPLEX Grouping > Flashcards

NAPLEX Grouping Flashcards

1
Q

Sulfa Allergy

A 
Thiazides
Darunavir
Zonisamide
Bactrim
Fosamprenavir
Loops except ethacrynic acid
Celecoxib

“That Damn Zealous Bitch Forgot Lemon Cookies”

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2
Q

Drugs that have a photosensitivity side effect

A 
Bactrim
Thiazides/Loop
Fluoroquinolones
MTX
Doxycycline

“Bitch Thanks For My Dermatitis”

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3
Q

Drugs that may cause DILE

A 
Hydrazaline
Methyldopa
BiDil
Quinidine
Procainamide
Amiodarone
Minocycline

“Hello My Bitchy Queen P.A.M.”

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4
Q

Drugs that decrease renal clearance of Lithium

A

Entresto
Salt intake
ACE-Is/ARBs
Diuretics

“Extra S.A.D.”

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5
Q

Drugs that uses “actual body weight” for dosing

A 
Insulins
Chemotherapy (actual BW for BSA)
Lovenox
UFH
Vancomycin

“I Can’t Love U Vic”

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6
Q

Drugs that cause piapism

A 
Sinemet
Trazodone
Stimulants
Lorcaserin
PDE-5 inhibitors
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7
Q

Drugs that needs to be screened for HLA-B* 1502

A

Phenytoin
Fosphenytoin
Carbamazepine
Oxcarbazepine

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8
Q

Smoking reduces the levels of these drugs:

A

Clozapine

Olanzapine

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9
Q

Avoid taking these drugs at bedtime

A

Fluoxetine (activating)
Bupropion (activating)
Pseudoephedrine

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10
Q

Drugs that discolor: Brown

A

Levodopa
Entacapone
Methyldopa

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11
Q

Drugs that discolor: Brown/Black/Green

A

Methocarbamol

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12
Q

Drugs that discolor: Purple/Orange/Red

A

Chlorzoxazone

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13
Q

Drugs that discolor: Brown/Yellow

A

Metronidazole
Tinidazole, Nitrofurantoin
B2

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14
Q

Drugs that discolor: Orange/Yellow

A

Sulfasalazine

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15
Q

Drugs that discolor: Yellow-green

A

Propofol

Flutamide

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16
Q

Drugs that discolor: Red-orange

A

Phenazopyridine
Rifapentine
Rifampin

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17
Q

Drugs that discolor: Red

A

Anthracyclines

Deferasirox (urine)

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18
Q

Drugs that discolor: Blue

A

Mitoxantrone

Methylene blue

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19
Q

Drugs that discolor: Blue-gray

A

Chloroquine

Amiodarone

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20
Q

Oncology - Take with food

A

Imatinib
Thalidomide
Capecitabine
Exemestane

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21
Q

Oncology - Take on empty stomach

A 
Nilotinib
Erlotinib
Sorafenib
Temozolomide
Abiraterone
Pomalidomide
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22
Q

Oncology - Extravasation

A

Anthracyclines

IV promethazine

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23
Q

Oncology - Drugs that cause neurotoxicity

A

Vincristine (Cr for cranium)
Taxanes
Cisplatin
Oxaliplatin (think of Olaf b/c of the cold sensitivity after chemo)

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24
Q

Oncology - Drugs that cause QT prolongation

A

Ondansetron
Vemurafenib
Crizotinib

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25
Q

Oncology - Drugs that cause alopecia

A

Vemurafenib
Carboplatin
Etoposide
Doxorubicin

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26
Q

Oncology - Special consideration in administration

A

Vincas are fatal if given intrathecally (typically given central line)

Anthracyclines need a central line due to extravasation b/c they’re vesicants

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27
Q

Oncology - Chemotherapy that needs prophylaxis “buddy”

Pemetrexed

A

B12 or folic acid for supplementation to lower levels of toxicity and dexamethasone to reduce rash

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28
Q

Oncology - Chemotherapy that needs prophylaxis “buddy”

Taxanes

A

H1 & H2 blockers and corticosteroids to prevent infusion reactions

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29
Q

Oncology - Chemotherapy that needs prophylaxis “buddy”

Immunotherapy agents

A

Corticosteroid to reduce immune related reactions

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30
Q

Oncology - Chemotherapy that needs prophylaxis “buddy”

Pembrolizumab

A

Dexamethasone to prevent immune related reactions

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31
Q

Oncology - Chemotherapy that needs prophylaxis “buddy”

Androgen Deprivation Therapy

A

Bisphosphonates (zoledronic acid or alendronate) for the bone SE + Ca and Vitamin D supplementation

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32
Q

Oncology - Chemotherapy that needs prophylaxis “buddy”

Abiraterone

A

Prednisone to replace the cortisol

33
Q

Oncology - Chemotherapy that needs prophylaxis “buddy”

Docetaxel or Cabazitaxel (2nd line)

A

Prednisone for prostate cancer chemotherapy (standard of care)

34
Q

Oncology - Major DDIs

Antifolates that decrease clearance from body

A

Omeprazole

35
Q

Oncology - Major DDIs

Erlotinib

A

CYP3A4
Warfarin
Omeprazole
Ranitidine

36
Q

Oncology - Major DDIs

BCR-ABL inhibitors

A

CYP3A4
CYP2D6
Statins

37
Q

Oncology - Major DDIs

Tamoxifen with what and why?

A

Tamoxifen is metabolized by CYP3A4, CYP2C19, & CYP2D6

Interacts with fluoxetine & paroxetine

38
Q

Oncology - Major DDIs

Capecitabine

A

warfarin (increase INR)

39
Q

Oncology - Major DDIs

Enzalutamide

A

CYP3A4
CYP2C8
CYP2C9
CYP2C19

40
Q

Oncology - Let’s treat nausea

Anticipatory

A

BZD

Olanzapine

41
Q

Oncology - Let’s treat nausea

Acute

A

BZD, dexamethasone
5HT3 antagonists
Cannabinoids
Olanzapine

42
Q

Oncology - Let’s treat nausea

Delayed

A

-prepitants
Dexamethasone (most effective)
Metoclopramide + dexamethasone

43
Q

Oncology - Let’s treat nausea

Breakthrough Treatment

A 
Phenothiazines (primarily)
5HT3 antagonists
Metoclopramide
Corticosteroids
Dronabinol
Olanzapine
Lorazepam
44
Q

Oncology - Let’s treat diarrhea

Normal diarrhea

A

Loperamide

Atropine/diphenoxylate (Lomotil)

45
Q

Oncology - Let’s treat diarrhea

Irinotecan associated with early diarrhea

A

Atropine

46
Q

Oncology - Let’s treat diarrhea

Irinotecan associated with late diarrhea

A

Loperamide (L for late)

47
Q

Oncology - Let’s treat constipation

Name laxatives

A

Senna

Bisacodyl

48
Q

Oncology - Let’s treat constipation

Name a Stool softener

A

Docusate sodium

49
Q

Oncology - Let’s treat constipation

Name Osmotics

A

PEG

Lactulose

50
Q

Oncology - Let’s treat constipation

Name a Prokinetic

A

Metoclopramide

51
Q

Oncology - Let’s treat constipation

Name a Saline

A

Mg citrate for rescue

52
Q

Oncology - Let’s treat constipation

Name an opioid receptor antagonist

A

Methylnaltrexone

53
Q

Oncology - Let’s treat constipation

AVOID these agents

A

Bulk forming
Suppositories
Enemas

54
Q

Oncology - Drugs that cause neuropathy

A 
~Oxaliplatin (DO NOT give to patient with DPN or > 70yoa)
~Bortezomib
~Carboplatin
~Paclitaxel (biggest problem)
~Cisplatin
55
Q

Oncology - Drugs that have infusion reactions

A

Taxanes
Rituximab
Cetuximab

56
Q

Oncology - Drugs that have hypersensitivity reactions

A 
Alkylating agents
Murine MoABs (-o)
Trastuzumab
Abiraterone
Cabazitaxel (DO NOT use if pt had rxn to docetaxel)
57
Q

Oncology - Drugs that cause constipation

A

Vincristine
Vinblastine
Cisplatin
Thalidomide

58
Q

Oncology - Let’s treat acneiform rash!

A

Topical HC or Clindamycin

Severe: Doxycycline or Minocycline

AVOID: OTC acne meds like benzoyl peroxide

59
Q

Oncology - Let’s treat hypercalcemia!

What is the regimen?

A

IV fluids: NS bolus & maintenance fluids PRN

Bisphosphonates: Zoledronic acid and Pamidronate

Calcitonin

Denosumab: max 4 doses

D/c any Ca or phosphate supplements

60
Q

Oncology - Mnemonics

Alkylating Agents & Anthracyclines work where in the cell cycle?

A

A for “any” phone of the cell cycle

61
Q

Oncology - Mnemonics

Carboplatin dose is calculated by what equation?

A

C for Calvert equation

62
Q

Oncology - Mnemonics

Oxaliplatin is exacerbated by what?

A

the cold

“Olaf”

63
Q

Oncology - Mnemonics

Bevacizumab has what side effect?

A

B for Bleeding!!

64
Q

Oncology - Mnemonics

Always remember which agent has to be administered first before carboplatin?

A

Paclitaxel before carboplatin

P for “prior”

65
Q

Oncology - Mnemonics

What is Erlotinib timing of administration?

A

E for “empty” stomach

66
Q

Oncology - Mnemonics

Equivalent dosing for 5HT3 antagonists:

A

“GOD”

Granisetron 2 mg
Ondansetron 24 mg
Dolasetron 100 mg

67
Q

Oncology - Mnemonics

What is the most common cytotoxic treatments for breast cancer?

A

Remember “TATAs”

Taxanes & Anthracyclines

68
Q

Oncology - Mnemonics

Interferon has no survival rate and causes flu-like symptoms

A

Interferon for inferior

69
Q

What drugs should be avoided with alcohol?

A

Flagyl
Warfarin
Nilutamide
Trokendi XR

70
Q

What agents are NOT to be shaked?

A

ESAs
Anti-TNF Biologic DMARDs for rheumatoid arthritis
NTG TL spray
Natalizumab

71
Q

What agents need “time off” intervals?

A

Lidocaine patches (12 hrs)
NTG (12-24 hrs)
ACE & ARNI washout period is 36 hrs

72
Q

What drugs are safe in pregnancy for HTN?

A

Labetalol
Nifedipine
Methyldopa

73
Q

What antibiotics must be taken with a full glass of water?

A 
Bactrim
Fluoroquinolones
Clindamycin
doxycycline
Minocycline
74
Q

What antibiotics have to be separated from antacids?

A

Fluoroquinolones
Nitrofurantoin
Doxycycline

75
Q

What antibiotics do NOT need to be refrigerated?

A 
Cefdinir
Clindamycin
Azithromycin
Ciprofloxacin
Bactrim
Clarithromycin
Doxcycline
76
Q

What antibiotics need to be taken with food?

A 
Amoxicillin
Augmentin
Cefuroxime
Flagyl IR
Nitrofurantoin
Clarithromycin
77
Q

What antibiotics need to be taken before/after a meal?

A 
Penicillin VK
Azithromycin XR
Flagyl IR
Levofloxacin
Doxycycline
Minocycline
78
Q

What antibiotics need to be refrigerated?

A 
Amoxicillin
Augmentin
Cephalexin
Cefuroxime
Penicillin VK
Erythromycin

NAPLEX 2023 (88 decks)

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