N/V/D/C Pharm

Question 1

odansetron

Answer 1

5 HT3 antagonist

Question 2

metoclopromide

Answer 2

D2 receptor antagonist

-substituted benzamide

Question 3

prochlorperazine

Answer 3

D2 receptor antagonist

-phenothiazine

Question 4

diphenhydramine

Answer 4

antihistamine

Question 5

promethazine

Answer 5

antihistamine

Question 6

dronabinol

Answer 6

cannabinoid

Question 7

antihistamine

Answer 7

motion sickness

Question 8

ondansetron MOA

Answer 8

block central serotonin receptor vomiting center, CTZ, and peripheral receptors

half life 4-9 hours

Question 9

QT prolongation

Answer 9

ondansetron

Question 10

acute CINV tx

Answer 10

ondansetron

Question 11

metoclopramide MOA

Answer 11

inhibits D2 like receptors in CTZ and solitary tract nucleus

also prokinetic abilities

Question 12

tx diabetic gastroparesis

Answer 12

metoclopramide

Question 13

immature muscle contractions, parkinson like sx

Answer 13

metoclopramide

Question 14

prochlorperazine MOA

Answer 14

inhibit D2 receptors

also antihistamine and anticholinergic

Question 15

general purpose antiemetic

Answer 15

prochlorperazine

Question 16

diphenyhdramine MOA

Answer 16

histamine H1 receptor antagonist

Question 17

promethazine MOA

Answer 17

histamine H1 receptor antagonist

Question 18

vertigo tx

Answer 18

antihistamines

Question 19

sedation, dry mouth, urinary retention

Answer 19

anticholinergics

Question 20

long boat trip

Answer 20

bad motion sickness

scopolamine patch

Question 21

anticipatory emesis

Answer 21

benzodiazepines

Question 22

acute CINV

Answer 22

less than 24 hours

use combo drugs

Question 23

delayed CINV

Answer 23

after 24 hours

prevent first acute CINV

Question 24

pregnancy

Answer 24

pyridoxine

Question 25

gastroparesis

Answer 25

metoclopramide

Question 26

loperamide

Answer 26

opiod

Question 27

bismuth

Answer 27

mucosal protectivec

Question 28

polyethylene glycol

Answer 28

osmotic laxitive

Question 29

saline laxative

Answer 29

osmotic laxative

Question 30

opiod agonist MOA

Answer 30

stimulate opiod receptor

increase transit time, increase fecal water absorption, decrease motility

Question 31

c. dificile

Answer 31

contraindication of loperamide

Question 32

to discourage loperamide abuse

Answer 32

atropine addition

Question 33

psyllium

Answer 33

bulk forming laxative

for long term prevention of constipation

Question 34

psyllium MOA

Answer 34

hydrophilic colloid that absorbs water

distends colon and activates peristalsis

Question 35

docusate

Answer 35

stool softener

Question 36

stool softener MOA

Answer 36

allow water and lipid to penetrate stool

useful for prevention

Question 37

polyethylene glycol MOA

Answer 37

osmotic laxative

soluble, non-absorbably increase stool liquidity to increaese fecal fluid

Question 38

polyethylene glycol

Answer 38

bowel preparation for colonoscopy

Question 39

senna

Answer 39

stimulant laxative

direct stimulation of enteric nervous system

Question 40

high dose opiod with severe constipation

Answer 40

senna

Question 41

long term neuro impaired bed bound pt with constipation

Answer 41

senna

Question 42

methylcellulose

Answer 42

1-3 days

Question 43

methylnaltrexone

Answer 43

inhibitor of opiod reeptor
does not cross BBB

only hospice care patients with constipation from opiod use

Question 44

bisacodyl suppository

Answer 44

stimulant

Question 45

constipation tx

Answer 45

increase fiber intake

Question 46

metoclopramide

Answer 46

• dopamine antagonist
• serotonin agonist (antagonist at high dose)

prokinetic - increase bowel motility