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GI II Exam 1 > IBD Pharm > Flashcards

IBD Pharm Flashcards

1
Q

infliximab

A

anti-TNF-alpha Ab

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2
Q

corticosteroids

A

prednisone
budesonide
hydrocortisone

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3
Q

5-ASA agents

A

delayed release
prodrugs
rectal formulations

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4
Q

rowasa and canasa

A

rectal formulation 5-ASA

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5
Q

delayed release 5-ASA

A

apriso
asacol
lialda
pantasa

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6
Q

prodrug 5-ASA

A

sulfasalazine
balsalazide
olsalazine

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7
Q

IBD

A

UC and crohns

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8
Q

sulfasalazine

A

5-ASA

prodrug

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9
Q

mesalamine

A

5-ASA

formulations

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10
Q

formulations of 5-ASA

A

so they don’t metabolize too early

can localize to specific site of inflammation

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11
Q

5-ASA MOA

A

modulate inflammatory mediators derived from COX and leukotrienes

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12
Q

1st line mild-to moderate UC

A

5-ASA

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13
Q

lialda and asacol

A

pH sensitive resin 5-ASA

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14
Q

pentasa

A

timed release 5-ASA

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15
Q

suppository 5-ASA

A

rowasa and canasa

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16
Q

adverse 5-ASA

A

sulfasalazine

nausea, GI upset, HA, arthralgia, BM suppression, malaise

17
Q

corticosteroid MOA

A

inhibit inflammatory cytokine production as well as chemokines

travel to nucleus - modulate gene transcription

18
Q

hydrocortisone

A

enema, foam, suppository

19
Q

insomnia

A

corticosteroids

20
Q

methotrexate

A

inhibits dihydrofolate reductase

21
Q

anti-TNF-alpha Abs MOA

A

binds soluble and membrane TNF with high affinity

prevent receptor binding
cause reverse signaling and suppress cytokine release

infliximab

22
Q

requires 17 weeks to be active

A

6 mercaptopurine

purine analog

23
Q

IBS tx

A 
laxative
antidiarrheals
prokinetics
5-HT3 antagonists
antispasmodics
antidepressants
24
Q

IBS

A

diarrhea or constipation with abdominal pain

25
Q

IBS therapy

A

1st - diet change

26
Q

lubiprostone

A

Cl channel activator

stimulates intestinal fluid secretion

27
Q

tegaserod

A

5-HT4 partial agonist

ischemic events increased risk

28
Q

antispasmodics

A

inhibit muscarinic cholinergic receptors

dicyclomine
hyscyamine

GI II Exam 1 (29 decks)

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