Liver Path I

Question 1

acute jaundice

Answer 1

<6 months

flu like sx, RUQ pain, acholic stool, choluria

pruritis, eruptive xanthomas

fulminant - encephalopathy

Question 2

chronic jaundice

Answer 2

cirrhosis
portal HTN - ascites, varices
fatigue, weak, weight loss
testicle atropy
hepatocellular carcinoma

Question 3

end stage disease

Answer 3

hepatic failure

hepatocellular carcinoma

Question 4

unconjugated hyperbilirubinemia

Answer 4

hemolysis
gilbert
crigler najjar

Question 5

mixed hyperbilirubinemia

Answer 5

hepatic or cholestatic path

Question 6

increased AST and ALT

Answer 6

hepatic

Question 7

increased alk phos and GGT

Answer 7

cholestatic

Question 8

AST > ALT

Answer 8

alcoholic liver disease

Question 9

AST < ALT

Answer 9

viral serology

Question 10

liver

Answer 10

glycogen homeostasis
albumin and clotting factor synthesis

catabolism of estrogen, drugs, toxins

excrete bile

Question 11

coelomic cavity

Answer 11

lining the digestive organs

-lining is mesoderm epithelium

Question 12

blood to liver

Answer 12

portal vein 75%

hepatic artery 25%

Question 13

porta hepatis

Answer 13

posterior fissure dividing caudate and quadrate lobes of liver
-carries portal a and v and hepatic duct

Question 14

support of liver in abdomen

Answer 14

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Question 15

budd chiari syndrome

Answer 15

obstruction of hepatic vein

-multiple trunks

Question 16

portal triad

Answer 16

portal vein
hepatic artery
bile duct

Question 17

kupffer cells

Answer 17

macrophages

Question 18

stellate cells

Answer 18

space of disse

also fibrosis production

Question 19

lobule

Answer 19

with central vein extending out to portal tract

blood toward central vein
bile toward bile duct

Question 20

acinus

Answer 20

triangle within lobule

Question 21

sinusoids

Answer 21

vessels to central vein in acinus

Question 22

zons of acinus

Answer 22

1 - close to portal tract - high O2
2 - middle O2
3 - low O2 - near central vein

Question 23

acetaminophen

Answer 23

damage of zone 3

Question 24

kupffer cells

Answer 24

in sinusouds

Question 25

canals of hering

Answer 25

basolateral hepatocytes - bile flow

Question 26

space of disse

Answer 26

between hepatocyte and endothelial of sinusoid

location of stellate cells

location of lymph fluid

stellate cells - contract to push lymph

Question 27

dendritic cells

Answer 27

in liver
-APCs

monitor portal circulation

Question 28

fibrosis space of disse

Answer 28

block lymph

-get ascites

Question 29

space of mall

Answer 29

portal tract

-can also get fibrotic leading to ascites

Question 30

cholangiocytes

Answer 30

lining the canal of hering
-bile transport

stem cells for regeneration of hepatocytes

Question 31

small ductule cholangiocyte

Answer 31

inflammation and proliferation

Question 32

large ductule cholangiocyte

Answer 32

secretin regulated

-volume/alkalinity

Question 33

limiting plate

Answer 33

around portal tract

Question 34

centrilobular

Answer 34

near central vein

Question 35

reticulin

Answer 35

stain - endothelial lining space of disse - type III collagen fibers

-single cell layering

Question 36

trichrome stain

Answer 36

type I collagen - increased in liver fibrosis

Question 37

dilation if bile canaliculi

Answer 37

with obstruction

Question 38

acute phase reactants

Answer 38

synthesized in liver

Question 39

storage of triglycerides, Fe, Cu

Answer 39

liver

Question 40

factor VIII

Answer 40

produced in endo cells in liver sinusoids

-liver transplant - cure hemophilia A

Question 41

stage of irreversible damage

Answer 41

membrane damage

Question 42

acidophil bodies

Answer 42

apoptosis

Question 43

councilman bodies

Answer 43

apoptotic cells in yellow fever

Question 44

periportal inflammation

Answer 44

portal tracts

Question 45

centrilobular inflammation

Answer 45

involving parenchyma

Question 46

liver regeneration

Answer 46

can occur if CT framework intact

Question 47

ballooning degeneration

Answer 47

in liver

Question 48

hepatocyte degeneration

Answer 48

feathery cytoplasm changes with bile stasis

Question 49

fatty liver

Answer 49

alcohol and NASH

Question 50

microvesicular steatosis

Answer 50

central nucleus
-small vacuoles of fat

• reye syndrome
• tetracycline toxicity
• pregnancy

Question 51

macrovesicular steatosis

Answer 51

displaced nucleus

-methotrexate toxicity

Question 52

alpha-1 antitrypsin deficiency

Answer 52

accumulation of proteins in cells