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GI II Exam 1 > Liver Path I > Flashcards

Liver Path I Flashcards

1
Q

acute jaundice

A

<6 months

flu like sx, RUQ pain, acholic stool, choluria

pruritis, eruptive xanthomas

fulminant - encephalopathy

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2
Q

chronic jaundice

A 
cirrhosis
portal HTN - ascites, varices
fatigue, weak, weight loss
testicle atropy
hepatocellular carcinoma
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3
Q

end stage disease

A

hepatic failure

hepatocellular carcinoma

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4
Q

unconjugated hyperbilirubinemia

A

hemolysis
gilbert
crigler najjar

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5
Q

mixed hyperbilirubinemia

A

hepatic or cholestatic path

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6
Q

increased AST and ALT

A

hepatic

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7
Q

increased alk phos and GGT

A

cholestatic

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8
Q

AST > ALT

A

alcoholic liver disease

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9
Q

AST < ALT

A

viral serology

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10
Q

liver

A

glycogen homeostasis
albumin and clotting factor synthesis

catabolism of estrogen, drugs, toxins

excrete bile

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11
Q

coelomic cavity

A

lining the digestive organs

-lining is mesoderm epithelium

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12
Q

blood to liver

A

portal vein 75%

hepatic artery 25%

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13
Q

porta hepatis

A

posterior fissure dividing caudate and quadrate lobes of liver
-carries portal a and v and hepatic duct

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14
Q

support of liver in abdomen

A

??

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15
Q

budd chiari syndrome

A

obstruction of hepatic vein

-multiple trunks

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16
Q

portal triad

A

portal vein
hepatic artery
bile duct

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17
Q

kupffer cells

A

macrophages

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18
Q

stellate cells

A

space of disse

also fibrosis production

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19
Q

lobule

A

with central vein extending out to portal tract

blood toward central vein
bile toward bile duct

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20
Q

acinus

A

triangle within lobule

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21
Q

sinusoids

A

vessels to central vein in acinus

22
Q

zons of acinus

A

1 - close to portal tract - high O2
2 - middle O2
3 - low O2 - near central vein

23
Q

acetaminophen

A

damage of zone 3

24
Q

kupffer cells

A

in sinusouds

25
Q

canals of hering

A

basolateral hepatocytes - bile flow

26
Q

space of disse

A

between hepatocyte and endothelial of sinusoid

location of stellate cells

location of lymph fluid

stellate cells - contract to push lymph

27
Q

dendritic cells

A

in liver
-APCs

monitor portal circulation

28
Q

fibrosis space of disse

A

block lymph

-get ascites

29
Q

space of mall

A

portal tract

-can also get fibrotic leading to ascites

30
Q

cholangiocytes

A

lining the canal of hering
-bile transport

stem cells for regeneration of hepatocytes

31
Q

small ductule cholangiocyte

A

inflammation and proliferation

32
Q

large ductule cholangiocyte

A

secretin regulated

-volume/alkalinity

33
Q

limiting plate

A

around portal tract

34
Q

centrilobular

A

near central vein

35
Q

reticulin

A

stain - endothelial lining space of disse - type III collagen fibers

-single cell layering

36
Q

trichrome stain

A

type I collagen - increased in liver fibrosis

37
Q

dilation if bile canaliculi

A

with obstruction

38
Q

acute phase reactants

A

synthesized in liver

39
Q

storage of triglycerides, Fe, Cu

A

liver

40
Q

factor VIII

A

produced in endo cells in liver sinusoids

-liver transplant - cure hemophilia A

41
Q

stage of irreversible damage

A

membrane damage

42
Q

acidophil bodies

A

apoptosis

43
Q

councilman bodies

A

apoptotic cells in yellow fever

44
Q

periportal inflammation

A

portal tracts

45
Q

centrilobular inflammation

A

involving parenchyma

46
Q

liver regeneration

A

can occur if CT framework intact

47
Q

ballooning degeneration

A

in liver

48
Q

hepatocyte degeneration

A

feathery cytoplasm changes with bile stasis

49
Q

fatty liver

A

alcohol and NASH

50
Q

microvesicular steatosis

A

central nucleus
-small vacuoles of fat

  • reye syndrome
  • tetracycline toxicity
  • pregnancy
51
Q

macrovesicular steatosis

A

displaced nucleus

-methotrexate toxicity

52
Q

alpha-1 antitrypsin deficiency

A

accumulation of proteins in cells

GI II Exam 1 (29 decks)

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