GI Physiology II Flashcards
1
Q
rennin
A
chymosin
-produced by chief cells in infants
inactive pro-enzyme - activated by acid exposure
causes milk to curdle in stomach - so released more slowly
replaced by pepsinogen as major protease
2
Q
pepsinogen
A
inactive secreted form of pepsin
from chief cells
converted to pepsin by acid
also - pepsin can convert more pepsinogen to pepsin
3
Q
chief cells
A
stimulated by ACh, histamine, gastrin/CCK
-release pepsinogen
4
Q
pepsinogen secretion activation
A
1 vagal stimulation - ACh
2 gastric acid
5
Q
IF
A
parietal cells
absorption of Vit B12
6
Q
cubulin
A
receptor for IF/B12 complex in terminal lieum
7
Q
numbness in extremities and weakness
A
pernicious anemia - vit B12 deficiency - neuro disturbances
8
Q
B12
A
required for DNA synthesis in RBC progenitor cells
9
Q
start on
A
slide 42
