Liver Path III Flashcards
consequences of cirrhosis, male
hepatic encephalopathy
esophageal varices
splenomegaly
consequences of cirrhosis, females
oligomenorrhea, amenorrhea, sterility, hypogonadism
jaundice
yellow staining of membranes by bilirubin
cholestasis
inability to excrete bile
bile salts
can lead to pruritis - itching
also malabsorption of fats - no Vit K dependent clot factors
cholesterol retention
eruptive xanthomas - periorbital or tendinous
canal of hering
travel of bile - to portal tract
small ductule cholangioncytes
canal of hering
imflammation/proliferation
large ductule cholangiocytes
volume/alkalinity
cholestasis and parenchyma
enlarged hepatocytes, dilated canalicular spaces, apoptotic cells, kupffer cells present
portal tract and cholestasis
edema, bile pigment retention, neutro inflammation
UDP
uridine diphosphatase - conjugates bilirubin with glucuronic acid
unconjugated bilirubin
binds albumin
-not excreted in kidney
conjugated bilirubin
does not bind albumin - lost in urine
urobilinogen
brown color of stool and yellow color of urine
choluria
dark urine
pale stool
in cholestasis
-no bilirubin to darken stool - stercobilinogen
unconjugated hyperbilirubinemia
hemolysis
gilbert
crigler najjar
mixed hyperbilirubinemia
look at AST, ALT, alk phos, and GGT
high AST, ALT - hepatic
high alk phos and GGT - cholestatic
AST < ALT
viral serology
AST > ALT
alcoholic liver disease
20-30yo with black liver
dubin johnson