Musculoskeletal System- MoA Flashcards
1
Q
Methotrexate
A
Inhibition of dihydrofolate reductase and DNA synthesis for lymphocyte proliferation
2
Q
Thiopurine antiproliferative
A
Inhibitor of purine synthesis – possible inhibition of DNA synthesis and lymphocyte proliferation
3
Q
Cytokine modulators
A
TNF-alpha blockade
4
Q
Aminosalicylates
A
Possible COX inhibition. Free radical scavenging, T cell suppression
5
Q
Leflunomide
A
Inhibitor of pyrimidine synthesis, reducing DNA & RNA synthesis and lymphocyte proliferation
6
Q
Colchicine
A
Possible inhibition of inflammatory cell motility
7
Q
Xanthine oxidase inhibitor
A
Inhibition of uric acid synthesis
8
Q
Indometacin
A
COX enzyme inhibition
