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Phase III: Drug List > Central Nervous System- MoA > Flashcards

Central Nervous System- MoA Flashcards

1
Q

Dopaminergics

A

Increased dopamine synthesis and dopaminergic function

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2
Q

Dopa-decarboxylase inhibitors

A

Stops breakdown of Levadopa in the periphery by inhibiting dopa-decarboxylase

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3
Q

Inhibitors of Monoamine Oxidase B (MAOI)

A

Inhibition of dopamine breakdown

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4
Q

Inhibitor of COMT (catechol-O-methyl transferase)

A

Blockade of dopamine precursor breakdown by inhibition of COMT

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5
Q

Anticholinergics

A

Blockade of acetylcholine function

Muscarinic cholinergic receptor antagonist

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6
Q

Dopamine-depleting drugs

A

Blocks VMAT, preventing uptake of DA into vesicles

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7
Q

Selective serotonin reuptake inhibitors (SSRIs)

A

Inhibition of serotonin (5HT) reuptake pump in synaptic cleft

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8
Q

Reversible Inhibitor of Monoamine Oxidase type A (RIMA)

A

Inhibits monoamine oxidase A, preferentially decreases breakdown of serotonin and noradrenaline

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9
Q

Tricyclic antidepressants (TCAs)

A

Inhibition of noradrenaline and serotonin reuptake in synaptic cleft, H1 antagonist, M1 antagonist, adrenergic antagonist

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10
Q

Atypical antidepressants

A

5-HT1A partial agonist (Busprione)
Noradrenaline reuptake inhibitor (Venlafaxine, Reboxetine)
Noradrenaline /Dopamine reuptake inhibitor (Buproprion)
Melatonin agonist (Agomelatine)
Alpha-2 antagonist (Mirtazepine)

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11
Q

Antipsychotics- Classical (also known as First Generation)

A

Selective D2 dopamine receptor blockade

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12
Q

Antipsychotics- Atypical (also known as Second Generation)

A

Selective D2 dopamine and 5-HT receptor blockade

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13
Q

Mood Stabiliser

A

Neuronal calcium channel blockade

Unclear – possible neuronal calcium channel blockade

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14
Q

Cholinesterase inhibitors

A

Inhibition of acetylcholinesterase (reversible)

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15
Q

NMDA receptor antagonist

A

VD blocker of NDMA receptors

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16
Q

Anxiolytics

A 
GABA PAM (gamma-subunit)
5-HT1A partial agonist (Buspirone)
17
Q

Non-benzodiazepine Hypnotic

A 
Modulation of the GABA-A receptor
GABA PAM (γ-subunit) Enhanced effects of GABA
18
Q

Anti-epilepsy drugs (AEDs)

A

Anticonvulsant, decrease neuronal transmission

Na+ channel blockers; (Ethosuximide-Ca2+ channel blocker)

19
Q

Benzodiazepines (BDZs)

A 
Enhanced effects of GABA neurotransmission
GABA PAM (γ-subunit) Enhanced effects of GABA
20
Q

BDZ Antagonist

A

Antagonises GABA signalling

21
Q

Barbiturates

A 
Enhanced effects of GABA neurotransmission
GABA PAM (β-subunit) Enhanced effects of GABA
22
Q

Weak analgesic/antipyretic

A

Non-opioid analgesic (precise MoA unknown)

Unclear – possible COX inhibitor in CNS

23
Q

NSAIDs

A

Non-selective COX inhibitors, blockade of prostaglandin synthesis

24
Q

COX2-selective NSAIDs

A

COX-2 inhibition, localised prostaglandin blockade

25
Q

Weak opioid analgesics

A

Stimulation of analgesic opioid receptors

26
Q

Strong opioid analgesics

A

Stimulation of analgesic opioid receptors

27
Q

Partial/mixed agonist opioid analgesics

A

Stimulation of analgesic opioid receptors

Modulation of analgesic opioid receptors (μ and )

28
Q

Opioid antagonist

A

Opioid receptor antagonist

29
Q

Opioid addiction management

A

Narcotic opioid replacement; opioid receptor agonist/modulator

30
Q

Drugs for neuropathic pain

A

VDCC antagonist (gabapentin, pregabalin)/ TCA (amitriptyline)

31
Q

Inhaled analgesics

A

Unclear

32
Q

Drugs used to treat migraine

A

Stimulation of 5-HT receptors (Sumatriptan); blockade of voltage-gated sodium & calcium channels (Topiramate)

33
Q

5-HT3-receptor antagonist (anti-emetic)

A

Serotonin type 3 (5-HT3) receptor blockade

34
Q

Busprione

A

5-HT1A partial agonist

35
Q

Sumatriptan

A

Stimulation of 5-HT receptors

36
Q

Topiramate

A

blockade of voltage-gated sodium & calcium channels

37
Q

D2-receptor antagonist

A

Dopamine D2 receptor blockade in the Chemoreceptor Trigger Zone

38
Q

Cyclizine

A

Histamine H1 receptor blockade

39
Q

Ondansetron

A

Serotonin type 3 (5-HT3) receptor blockade

Phase III: Drug List (48 decks)

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