GI System- MoA Flashcards
Antacids
Antacids + alginates
Gastric acid neutralisation
H2-receptor antagonists
Blockade of gastric H2 histamine receptors
PPIs
Blockade of stomach acid transporters
Pancreatic enzymes
Restoration of pancreatic enzymes
Bulk laxatives
Water absorption in intestinal lumen to bulk stools
Faecal softener
Stimulates water & electrolyte secretion into intestinal lumen
Lower surface tension - allowing water and fat to enter stool, softening stool consistency & increasing bulk to aid transit
Osmotic laxatives
Water retention in intestinal lumen
Stimulant laxatives
Increase intestinal motility
Opioid anti-motility agents
Agonist for u-opioid receptors in myenteric plexus. Blocks intestinal muscarinic receptors
Paracetamol antidote
Restoring & maintaining hepatic intracellular glutathione required for paracetamol detoxification
Benzodiazepine (for alcohol withdrawal)
Potentiation of GABAA receptors
Non-benzodiazepine hypnotic (for alcohol withdrawal)
GABA mimetic - GABAA receptor agonist
Substance abuse treatment agent (for alcohol rehabilitation)
GABA mimetic - GABAA receptor agonist; possible NMDA receptor antagonist