GI System- MoA Flashcards

1
Q

Antacids

Antacids + alginates

A

Gastric acid neutralisation

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2
Q

H2-receptor antagonists

A

Blockade of gastric H2 histamine receptors

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3
Q

PPIs

A

Blockade of stomach acid transporters

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4
Q

Pancreatic enzymes

A

Restoration of pancreatic enzymes

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5
Q

Bulk laxatives

A

Water absorption in intestinal lumen to bulk stools

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6
Q

Faecal softener

A

Stimulates water & electrolyte secretion into intestinal lumen
Lower surface tension - allowing water and fat to enter stool, softening stool consistency & increasing bulk to aid transit

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7
Q

Osmotic laxatives

A

Water retention in intestinal lumen

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8
Q

Stimulant laxatives

A

Increase intestinal motility

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9
Q

Opioid anti-motility agents

A

Agonist for u-opioid receptors in myenteric plexus. Blocks intestinal muscarinic receptors

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10
Q

Paracetamol antidote

A

Restoring & maintaining hepatic intracellular glutathione required for paracetamol detoxification

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11
Q

Benzodiazepine (for alcohol withdrawal)

A

Potentiation of GABAA receptors

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12
Q

Non-benzodiazepine hypnotic (for alcohol withdrawal)

A

GABA mimetic - GABAA receptor agonist

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13
Q

Substance abuse treatment agent (for alcohol rehabilitation)

A

GABA mimetic - GABAA receptor agonist; possible NMDA receptor antagonist

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