Endocrine System/Treatment of Diabetes and Obesity- MoA

Question 1

Blood glucose-reducing hormones/ synthetic insulins

Answer 1

Stimulation of glucose uptake by cells

Question 2

Metformin

Answer 2

Increases insulin sensitivity, inhibits hepatic gluconeogenesis

Question 3

Gliclazide

Answer 3

Stimulates pancreatic insulin secretion

Question 4

Pioglitazone

Answer 4

Increases insulin sensitivity in muscle and adipose tissue

Question 5

Glucagon-like peptide-1 receptor (GLP-1) agonist

Answer 5

Incretin analogue- improves glucose control

Question 6

Sitagliptin

Answer 6

Reduces inactivation of incretins

Question 7

Orlistat

Answer 7

Inhibition of GI uptake of dietary fat

Question 8

Thyroid hormones

Answer 8

Synthetic hormones

Question 9

SGLT-2 Inhibitor

Answer 9

Blockade of renal glucose-sodium co-transporter

Question 10

Fenofibrate

Answer 10

Activation of PPAR-alpha transcription factor

Question 11

Desmopressin

Answer 11

Agonist for antidiuretic hormone receptors

Question 12

Dopamine receptor agonists

Answer 12

Stimulation of D2 receptors in pituitary for prolactin secretion

Question 13

Anti-thyroid drugs

Answer 13

Inhibition of TPO enzyme