Infections-MoA Flashcards
Beta lactams (penicillins, carbapenems, cephalosporins)
Inhibition of bacterial cell wall synthesis
Trimethoprim
Inhibition of dihydrofolate reductase
Ciprofloxacin
Inhibition of bacterial DNA gyrase
Erythromycin, azithromycin
Inhibition of bacterial protein synthesis
Doxycycline, tetracycline
Inhibition of bacterial protein synthesis
Nitrofurantoin
Bacterial DNA interference
Gentamicin
Inhibition of bacterial protein synthesis
Vancomycin
Inhibition of cell wall synthesis in Gram-positive bacteria
Metronidazole
Inhibition of bacterial DNA synthesis
Isoniazid, ethambutol
Inhibition of mycobacterial cell wall synthesis
Rifampicin
Inhibition of mycobacterial RNA synthesis
Interferon alpha
Activation of antiviral intracellular and immune responses
Aciclovir, ganciclovir
Virus replication blockade
Oseltamivir
Prevention of viral budding and infectivity
Ribavirin
Disrupts viral RNA synthesis
Tenofovir
Blockade of viral reverse transcriptase function for viral genetic replication
Lopinavir
Blockade of viral protease required for virus particle assembly
Dolutegravir
Disrupts integration of HIV genome into host chromosomes
Enfuvirtide
Blockade of virus fusion to target cell membrane
Maraviroc
Blockade of HIV binding to co-factor for cell entry
Triazole anti-fungal agent
Disruption of fungal membrane function
Clindamycin
Inhibition of bacterial protein synthesis
Gentamicin
Inhibition of bacterial protein synthesis
Reverse transcriptase inhibitors
Blockade of viral reverse transcriptase function for viral genetic replication
Ritonavir
Blockade of viral protease required for virus particle assembly
Mebendazole
Disruption of microtubule assembly in helminth cells
Permethrin
Inhibits invertebrate neural sodium channels, causing paralysis of pests
Nevirapine
Blockade of viral reverse transcriptase function for viral genetic replication
