Central Nervous System- Adverse Effects/Interactions

Question 1

Dopaminergics

Answer 1

Confusion, agitation

MAOI

Question 2

Dopa-decarboxylase inhibitor

Answer 2

Confusion, agitation

Question 3

Inhibitor of COMT (catechol-O-methyl transferase)

Answer 3

Nausea, vomiting

Question 4

SSRIs

Answer 4

Insomnia, Nausea

NSAIDs, Lithium

Question 5

Reversible inhibitor of monoamine oxidase type A (RIMA)

Answer 5

Tachycardia

Question 6

TCAs

Answer 6

Anticholinergic syndrome, prolonged QT syndrome

Question 7

Antipsychotics- Classical (also known as First Generation)

Answer 7

Blurred vision, tremor, extrapyramidal symptoms, hypotension

Question 8

Antipsychotics- Atypical (also known as Second Generation)

Answer 8

Extrapyramidal symptoms (less than classical antipsychotics), hypotension

Question 9

Mood Stabiliser

Answer 9

Tremor, hypothyroidism

NSAIDs, ACE inhibitors

Question 10

Cholinesterase inhibitors

Answer 10

Nausea, vomiting

Question 11

NMDA receptor antagonist

Answer 11

Constipation, hypertension

Question 12

Anti-epilepsy drugs (AEDs)

Answer 12

Drowsiness, rash, nausea, blurred vision
Hepatotoxicity (valproate); hyponataemia (carbamazepine)

Macrolide antibiotics

Question 13

Benzodiazepines (BDZs)

Answer 13

Drowsiness, dependence

Sedatives

Question 14

Barbiturates

Answer 14

Drowsiness, fainting

Sedatives, anti-coagulants

Question 15

Weak analgesic/antipyretic

Answer 15

Constipation

Warfarin

Question 16

NSAIDs

Answer 16

GI disturbance, hypertension, Aspirin not suitable for under 16s

Diuretics, ACE inhibitors,

Question 17

COX2-selective NSAIDs

Answer 17

Indigestion

ACE inhibitors, SSRIs

Question 18

Weak opioid analgesics
Strong opioid analgesics
Partial/mixed agonist opioid analgesics

Answer 18

Constipation, nausea

Sedatives

Question 19

Opioid antagonist

Answer 19

Nausea, tachycardia

Question 20

Opioid addiction management

Answer 20

Constipation

Sedatives

Question 21

Gabapentin, Pregabalin, Amitriptyline

Answer 21

Dizziness, fatigue

Antidepressants

Question 22

Inhaled analgesics

Answer 22

Decreased vitamin B12 synthesis

Question 23

Inhibitor of monoamine oxidase B

Answer 23

Arrhythmias

Question 24

Dopamine-depleting drugs

Answer 24

Parkinsonism, anxiety

Question 25

Atypical antidepressants

Answer 25

Anxiety, aggression

Question 26

Non-benzodiazepine hypnotic

Answer 26

Dry mouth, daytime drowsiness

Question 27

BDZ antagonist

Answer 27

Tremor, insomnia

Question 28

Drugs used to treat migraine

Answer 28

Flushing, asthenia

Question 29

5-HT3-receptor antagonist

Answer 29

Headache

Question 30

Anticholinergics

Answer 30

Dry mouth, constipation

Question 31

Cyclizine

Answer 31

Dry mouth, sedation

Sedatives

Question 32

D2-receptor antagonist

Answer 32

Cardiac disease