Anaesthetics - MoA Flashcards
Propofol, isoflurane, sevoflurane
Possible enhancement of GABA function
Ketamine
NMDA receptor blockade
Local anaesthetics
Voltage-gated sodium channel blockade
Atracurium besilate, vecuronium
Competitive antagonist at AChR
Suxamethonium
Initially depolarisation and desensitisation AChR
Sugammadex
Oligosaccharide that forms a complex with Vecuronium & Rocuronium removing them from NMJ
Oligosaccharide that forms a complex with NMBs
Neostigmine
Peripheral acetylcholinesterase inhibitor
Dexmedetomidine
Alpha-2 agonists inhibit sympathetic activity
Cyclizine
Histamine H1 receptor blockade
Domperidone
Dopamine D2 receptor blockade in the chemoreceptor trigger zone
Neuromuscular blockers
Acetylcholine blockade