Anti-neoplastic Drugs- MoA

Question 1

Cyclophosphamide

Answer 1

DNA crosslinking

Question 2

Texanes

Vinca alkaloids

Answer 2

Inhibition of microtubule assembly in mitotic spindle

Question 3

Methotrexate

Answer 3

Inhibition of dihydrofolate reductase and DNA synthesis

Question 4

Antipyrimidines

Antipurines

Answer 4

Inhibition of RNA and DNA synthesis

Question 5

Anthracycline Antibiotics

Answer 5

DNA intercalation; Inhibition of RNA and DNA synthesis

Question 6

Trastuzumab

Answer 6

Targeting of cells over expressing Human Epidermal Growth Factor Receptor-2 (HER2) for tumour reduction & destruction

Question 7

Rituximab

Answer 7

Targeted destruction of CD20+ B cells

Question 8

Nivolumab

Answer 8

Stimulation of anti-tumour responses via blocking PD-1

Question 9

Immunomodulator

Answer 9

Stimulation of T cell responses

Question 10

Selective estrogen receptor modulator (SERM)

Answer 10

Inhibition of oestrogen receptor function and cell proliferation in breast

Question 11

Luteinising hormone releasing hormone (LHRH) receptor agonist

Answer 11

Synthetic analogue of LHRH. Activates LHRH receptor function leading to sustained reduction in testosterone