Muscle Relaxers Flashcards
Which drugs are centrally acting spasmolytics?
baclofen
diazepam
Tinzanidine
Which drug is a centrally acting anti spasmotic?
cyclobenzaprine
Which drug is a centrally acting anti spasmotic? CNS depression
- carisporodol
- methacarbamol-most commonly used
- orphenadrine
which drugs have direct muscle action?
Dantrolene
Botulinum toxin
Name 2 OTC muscle relaxers?
chloroxazone -like cyclobenzaprine
metaxalone-CNS depression
T/F Spasmolytics tx upper motor neuron lesions
TRUE
T/F anti-spasmotics treat spasms in peripheral MSK conditions
TRUE
What is MOA of baclofen?
- facilitates spinal inhibition of motor neurons by reducing excitatory NT release in brain and spinal cord
- activates GABA receptors in pre and post synaptic
What is Clinical use of baclofen?
cerebral palsy, MS, stroke
What are ADE of balcofen?
- sedation
- muscle weakness
What is MOA of diazepam?
- GABA a receptor activation in post synaptic terminals
- facilitates gabanergic transmission in CNS
- increases inter neuron inhibition on primary motor afferents in SC.
What is clinical use of diazepam?
-spasm due to muscle injury
What are ADE of diazepam?
- abuse potential
- antegrade amnesia
- sedation
- additive affect with other CNS depressants
what is MOA tinzanidine?
- blocks pre and post synaptic reflex motor output
- 1/15 responsible for lowering BP in clonidine
What is clinical use of tinzanidine?
MS, ALS, stroke
what are ade of tinzanidine?
sedation, weakness, hypotension
What is MOA of cyclobenzaprine?
blocks muscle stretch reflex
- anti-muscarininc effects
- reduces hyerpactive muscles
What is clinical use of cyclobenzaprine?
acute muscle spams from an injury
What are ADE cyclobenzaprine?
anti-muscarinic effects
sedation confusion, ocular defects
what is MOA of dantrolene?
weakens muscle by reducing actin myosin intercation
-block R1R2 calcium release channels in SR of SM
What is clinical use of dantrolene?
-CP, MS, IV form used for malignant hyperthermia
What are ADE of dantrolene?
muscle weakness
What is MOA of botulinum?
cleaves fusion proteins in nerve endings
-flaccid paralysis
what are clinical uses of botulinum?
HA
- over active bladder
- CP, MS
