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Pharmacology > Muscle Relaxers > Flashcards

Muscle Relaxers Flashcards

1
Q

Which drugs are centrally acting spasmolytics?

A

baclofen
diazepam
Tinzanidine

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2
Q

Which drug is a centrally acting anti spasmotic?

A

cyclobenzaprine

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3
Q

Which drug is a centrally acting anti spasmotic? CNS depression

A
  • carisporodol
  • methacarbamol-most commonly used
  • orphenadrine
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4
Q

which drugs have direct muscle action?

A

Dantrolene

Botulinum toxin

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5
Q

Name 2 OTC muscle relaxers?

A

chloroxazone -like cyclobenzaprine

metaxalone-CNS depression

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6
Q

T/F Spasmolytics tx upper motor neuron lesions

A

TRUE

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7
Q

T/F anti-spasmotics treat spasms in peripheral MSK conditions

A

TRUE

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8
Q

What is MOA of baclofen?

A
  • facilitates spinal inhibition of motor neurons by reducing excitatory NT release in brain and spinal cord
  • activates GABA receptors in pre and post synaptic
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9
Q

What is Clinical use of baclofen?

A

cerebral palsy, MS, stroke

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10
Q

What are ADE of balcofen?

A
  • sedation

- muscle weakness

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11
Q

What is MOA of diazepam?

A
  • GABA a receptor activation in post synaptic terminals
  • facilitates gabanergic transmission in CNS
  • increases inter neuron inhibition on primary motor afferents in SC.
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12
Q

What is clinical use of diazepam?

A

-spasm due to muscle injury

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13
Q

What are ADE of diazepam?

A
  • abuse potential
  • antegrade amnesia
  • sedation
  • additive affect with other CNS depressants
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14
Q

what is MOA tinzanidine?

A
  • blocks pre and post synaptic reflex motor output

- 1/15 responsible for lowering BP in clonidine

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15
Q

What is clinical use of tinzanidine?

A

MS, ALS, stroke

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16
Q

what are ade of tinzanidine?

A

sedation, weakness, hypotension

17
Q

What is MOA of cyclobenzaprine?

A

blocks muscle stretch reflex

  • anti-muscarininc effects
  • reduces hyerpactive muscles
18
Q

What is clinical use of cyclobenzaprine?

A

acute muscle spams from an injury

19
Q

What are ADE cyclobenzaprine?

A

anti-muscarinic effects

sedation confusion, ocular defects

20
Q

what is MOA of dantrolene?

A

weakens muscle by reducing actin myosin intercation

-block R1R2 calcium release channels in SR of SM

21
Q

What is clinical use of dantrolene?

A

-CP, MS, IV form used for malignant hyperthermia

22
Q

What are ADE of dantrolene?

A

muscle weakness

23
Q

What is MOA of botulinum?

A

cleaves fusion proteins in nerve endings

-flaccid paralysis

24
Q

what are clinical uses of botulinum?

A

HA

  • over active bladder
  • CP, MS
25
Q

route of Botulinum?

A

injections 2-3 monthly

26
Q

What are ADE of botulinum?

A

falls

muscle weakness

27
Q

Why is carisprodol not used?

A

scheduled 4 drug that is metabolized to meprobamate which is a powerful sedative
-causes withdrawal symptoms anxiety, tremor, and insomnia

28
Q

Which centrally acting anti-spasmodic is OTC?

A

Metaxalone

Pharmacology (47 decks)

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