HIV Flashcards
What are the seven stages of the HIV life cycle?
- Binding: attachment of virus to CD4 cells
- Fusion
- Reverse transcription: viral RT is used to convert viral RNA into DNA to allow for inclusion into host DNA
- Integration: viral integrase is used to insert viral DNA into host DNA
- Replication: virus uses host machinery to make viral proteins
- assembly: non-infectious , viral proteins migrate towards surface of the cell to assemble
- budding: protease enzyme cleaves the HIV and releases a mature infectious virus
What is MOA of NRTI?
block reverse transcriptase
What is MOA of NNRTI?
bind and later alter Reverse Transcriptase
What is MOA of PI?
blocks protease so the HIV wont mature and get released
What is MOA of FI?
fusion inhibitors block the entry of HIV into CD4 cells
What is MOA of CCR5-I?
CCR5 inhibitors block the CD4 CCR5 co receptors that allows HIV to enter the cell
What is MOA of integrase inhbitors/INSTI?
integrase inhibitors block integrase an HIV enzyme that is needed to integrate viral DNA into host DNA
What is MOA of post attachment receptors?
block CD4 cell receptors that HIV needs to enter a cell
What is MOA of pharmacokinetic enhancers?
this medication work by increasing the efficacy of a
HIV drug medication in certain regimen?
Name a few barriers to HIV med adherence (7)?
- poor patient clinician relationship
- lack of understanding HIV disease
- no family support
- denial
- poor social situation
- complicated dosing regimen
- medication side effect
What is the hallmark of untreated HIV infection?
-depletion of CD4 T-lymphocyte cells
What are the 2 goals of ART?
- suppress viral replication
- increase CD4 cell count
Abacovir? Emtricitabine? Tenofovir?
NRTI
Doravirine? Efavirenz?Rilpivirine?
NNRTI
Atazanavir? Ritonavir?
PI
