Angina Flashcards
1
Q
What is MOA of nitrates?
A
-NO causes vasodilation by activating guanylyl cyclase which then activates cGMP which form myosin LC-vasodilation
2
Q
T/F Nitroglycerin is used in acute HF or angina
A
TRUE
3
Q
What are some adverse effects of nitrates (2)?
A
- hypotension
- reflex tachycardia
4
Q
What are the applications of Nitrates(3)?
A
- prophylaxis
- ACS
- Angina
5
Q
What are ADE with nitrates?(3)
A
- tachycardia
- headache
- orthostatic hypotension
6
Q
What is the clinical application of transdermal nitroglycerin?
A
- prophylaxis oral and trans dermal
- IV used in ACS
- sublingual used in acute episodes of angina
7
Q
What are the bad effects of nitrates?
A
- decreased diastolic filling
- reflex tachycardia
- increase in contractility
8
Q
Name the 5 drugs used to treat angina?
A
- CCB
- BB
- nitrates
- Ranolazine
- Ivabradine
9
Q
What is MOA of Ranolazine?
A
blocks NA channels in heart to reduce oxygen demands in heart
10
Q
What are ADE of Ranolazine?
A
QT prolongation
11
Q
What are the clinical uses of Ranolazine?
A
- prophylaxis for stable angina
- increases exercise capacity when added to other anti-anginal therapies?
