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Pharmacology > Derm 2 > Flashcards

Derm 2 Flashcards

1
Q

parthenogenesis of acne?

A

hyper seborrhea
follicular keratinization
propionibacteria acnes prilifration into unit

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2
Q

comedonal non inflammatory acne tx?

A

topical retinoid: adapalene and benzoyl peroxide

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3
Q

what tx the inflammation?

A

topical steroids, abx, estrogen

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4
Q

what tx the hyperkeritinazton?

A

salicylic acid

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5
Q

what tx the bacteria?

A

abx

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6
Q

what tx the sebaceous componets?

A

anti-androgens

estrogen

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7
Q

what is x for mod papulopustular acne?

A

adapalene and benzoyl peroixde

+ hormonal therapy if trunk is involved

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8
Q

Tx for severe acne?

A

adapalene and benzoyl peroxide

+ oral abx, oral anti-androgen, hormonal therapy

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9
Q

What is tx for males with conglobate acne?

A

oral isotretinoin

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10
Q

What is tx for females with conglobate acne

A

oral isotretinoin and anti-androgenic hormonal therapy or high dose oral abx

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11
Q

What is maintenance therapy for acne?

A

topical retinoids
topical retinoid and benzoyl peroxide
topical azelaic acid

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12
Q

T/F topical or oral abx should never be used as monotherapy in acne?

A

TRUE

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13
Q

what topical retinoid is safe for pregnant women?

A

topical azelaic acid

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14
Q

retionids?

A

acid form of vitamin A
avoid eyes, corners of nose, mouth
4- 6 weeks of therapy
increased used increases collagen and thickness off epidermis

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15
Q

which retinoid is category x pregnancy? what is SRA with the retinoids

A

tazarotene
Adapalene” beta, gamma
tazarotene betta, gamma
tretinoin: alpha, beta, gamma

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16
Q

Isotretinoin

A

tx: 20 weeks
ADE: thinning hair, chelitis, conjunctivitis, joint, depression, suicidal thoughts, insomnia, high triglycerides

Mionitor
CBC and LFT-1 st month
every month: pregnancy, fasting lipid levels

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17
Q

how many forms of birth control must be used with accutane?

A

2- month prior and for one menstrual cycle after discontinuation
-obtain serum pregnancy 2 weeks before starting therapy

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18
Q

Benzoyl peroxide

A

bacterostatic against P acnes

19
Q

what are topical abx in acne?

A

erythromycin and 1 % clindamycin

20
Q

ADE of erythromycin?

A

burning and stinging, irritation

21
Q

What is tx for Acne vulgaris?

A

tetracycline Doxy, lupus, gray skin
,erythomycin, GI upset
clindamycin- C. diff

22
Q

Azelaic acid?

A 
anti-inflammatory
normalizes kearyinization
bacteriostatic to P. acne
reduces sebum
ADE: itching, burning, hypopigmentation in darker skin
23
Q

intralesional steroids?

A

used for nodular acne

ADE: local atrophy, systemic absorption, adrenal issues

24
Q

Rosacea tx?

A

topical abx: BP clinda, erythro
ivermectin
DONT use corticosteroids
topical brimonidine used for redness

25
Q

Which topical abx is useful in rosacea?

A

Metronidazole

26
Q

Which topical is useful in papulopustular rosacea?

A

Invermectin -commensal mite might cause rosacea

27
Q

What is MOA of ivermectin?

A

anti-inflammatory and acaricidal against demodex mite

28
Q

ADE of ivermectin?

A

topical irritation and burning

29
Q

Topical imidazoles?

A

-miconazole, clotimazole,

30
Q

what is tx for seborrheic dermatitis?

A

topicla ketaconazole

31
Q

what is clincial use Topical imidazoles?

A

dematophytes or candia sp

clears in 2-3 weeks

32
Q

What is the use nystatin?

A

oral mucosal candida

33
Q

What is tx for atopic derm?

A

tacrolimus

34
Q

What is MOA of tacrolimus?

A

prevents acitavtion of t cell ans degranulation of IgE mast cells

35
Q

What are BBW of tacrolimus?

A
  • can cause cancer
  • dot use in children less than 2
  • dont use with occlusive dressing
36
Q

Tx for pruritus?

A
  • use low pH soap, CeraVE, cetaphil, aveeno, dove
  • no green or orgnage soaps, no ivory
  • apply CereVe 3min after bathing
37
Q

Topical doxipen? ADE?

A

-causes anti-cholinergic effects
-drowsiness
-H1 and H2 blcoker
dont use in urinary retention or glaucoma

38
Q

scabies tx?

A

premethrin 5% cream

-apply from neck and down for 8-12 hrs, then wask oof

39
Q

Lindane/ Hydrochlorohexane?

A

used for lice and pubic lice

  • can stay infatt tissue and brain: cause neuro problems
  • place shampoo o =n dry head for 4 min then wask off
40
Q

Crotimaton?

A

scabidice with an anti itching porperties

apply twic from chin down in 24 hour intervals, take bath within 48 hrs of last applicatio

41
Q

Which tx is used in pregnant women with ectoparasites

A

5% sulfur compounded with petrolatum

42
Q

What is used to tx hyperpigmentation?

A

-hydroquinone, mequinol, MBEH
MOA: blocks tyrosine in development of melanin
-monobenzene: irreverisble hypopigmentation

43
Q

What is tx for vitiligo?

A

Trioxsalen or methoxypsorealen

Risks: caracts, skin cancer

Pharmacology (47 decks)

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