Adrenal Disease Flashcards

1
Q

What is CBG?

A

Binds about 90% of the circulating cortisol under normal circumstances

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2
Q

Decreased CBG

A

hypothyrodism

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3
Q

Increased CBG

A

hyperthyroidsm

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4
Q

T/F Steroids inhance effect of bronchodilators

A

true

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5
Q

PK of cortisol

A

metabolized in liver

released in urine

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6
Q

Chronic Adrenocortical Insufficiency

A

Addison’s

dysfunction or absence of the adrenal cortices

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7
Q

Acute Adrenalcorticol insufficiency

A

Adrenal crisis
-Emergency state due to insufficient cortisol
Sx: Low blood pressure, dehydration, skin pigmentation may be increased

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8
Q

Hypercortisolism

A

Cushing “Syndrome” (drugs)

Cushing “Disease”* (tumor)

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9
Q

Tx for adrenal crisis

A
  1. Hydrocortisone 100-300mg IV; 50-100mg every 6-8 h and adjust to response
  2. Fludrocortisone acetate orally added as IV hydrocortisone dose is decreased
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10
Q

Fluticortisone MOA?

A

strong receptor of mineralcorticoid receptor

aka mineralcorticoid agonsit

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11
Q

CLinical use of fluticortisone

A

adrenal insufficiency, Addison’s disease

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12
Q

Tx for Addison’s disease

A

Combination of corticosteroids (alone if mild) and mineralocorticoids

Hydrocortisone 15–30 mg orally daily is drug of choice with 2/3 of dose given in the am and 1/3 given in the late afternoon

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