Derm Pharm I

Question 1

What are the factors that affect penetrance?

Answer 1

• concentration of medications
• thickness of skin
• frequency of application
• occlusiveness of the vehicle

Question 2

what determines efficacy of a drug?

Answer 2

potency and ability to penetrate

Question 3

Rank from most penetrable to least? 10

Answer 3

mucous membranes>scrotum>eyelids>face>chest/back>upper arms and legs>lower arms and legs>dorsa of hands and feet>palmar and plantar> nails

Question 4

T/F Application of a plastic wrap maximizes efficacy

Answer 4

TRUE

Question 5

What is most common drug vehicles?

Answer 5

Ointment

cream

Question 6

Rank vehicles from most to least potent

Answer 6

ointment>cream>lotion>gel>spray>foam

Question 7

what are the principles of dermatological therapy? (5)

Answer 7

• reduce inflammation
• relieve symptoms
• promote healing
• restore skin barrier
• prevent complications

Question 8

What is necessary in a prescription for topicals?

Answer 8

• vehicle
• concentration
• frequency
• quantity
• location
• timing

Question 9

how do you increase absorption?

Answer 9

apply water before applying medication, warp with cellophane, plastic wrap, nylon, cotton socks, dressing

Question 10

what is vehicle for oozing dermatosis?

Answer 10

wet dressing

lotions

Question 11

what is tx for thick, scaly, lichenified?

Answer 11

ointment, paste

Question 12

what is tx for general eruptions?

Answer 12

lotions

Question 13

What is non occlusive dressing?

Answer 13

• gauze
• allows air flow
• lesions drys

Question 14

wet to dry occlusive dresssing?

Answer 14

• wetted saline soln
• for crusted lesions
• applied wet and removed dry
• dry skin attaches to dressing

Question 15

occlusive dressing?

Answer 15

• plastic wrap

- increase effectiveness of topical therapy

Question 16

What is MCC of ADE in topical drugs?

Answer 16

allergic and contact dermatitis

Question 17

What is MOA of corticosteroids?

Answer 17

antimitotic effects on epidermis

Question 18

T/F Ten fold increase of steroid when wrapped in plastic

Answer 18

true

Question 19

T/F Steroid has minimal absorption when applied to the normal skin

Answer 19

True

Question 20

T/F Steroid penetration increases in inflamed skin

Answer 20

True

Question 21

High potency steroids class 1 tx what skin areas?

Answer 21

scalp, palms, soles, plaques

Question 22

medium potency steroid tx what skin areas? II-V

Answer 22

non facial

Question 23

low potency steroids tx for what skin aereas? V

Answer 23

face,
*face eyelid
d

Question 24

what is duration of tx super high potency class I?

Answer 24

< 3 weeks

Question 25

what is duration of tx for medium potency ?

Answer 25

6-8 weeks

Question 26

what is duration of tx for low potency ?

Answer 26

1-2 week intervals to avoid telangtecsia, atrophy, acne

Question 27

Class I?

Answer 27

Clobetosol propionate 0.05% cream or ointment

Question 28

Class II?

Answer 28

Betamethasone propionate .05% cream

fluocinonide 0.05% cream, gel