Hep C

Question 1

What is MOA if NS3/4A?

Answer 1

protease inhibitors, prevents glycoprotein processing

Question 2

What is MOA of NS5B-I?

Answer 2

blocks RNA polymerase activity

Question 3

What is MOA of NS5A-I?

Answer 3

prevents viral assembly

Question 4

What is MOA of ribavirin?

Answer 4

blocks replication of RNA and DNA

Question 5

What are two drugs of NS3/4A?

Answer 5

Grazoprevir

Glecaprevir

Question 6

What are the NS5A drugs ?

Answer 6

Elbasvirsfosbuvir/velpatsvir for
Pibrentasvir
Ledipasvir
Velpatasvir

Question 7

What are NS5B drugs?

Answer 7

sofosbuvir

Question 8

What is tx for tx naive pt without cirrhosis in genotype 1a?

Answer 8

glecaprevir/pibrentasvir x 8 weeks with food
elbasvir and grazoprevir x 12 weeks

sofosbuvir/ledispavir for 12 weeks
*Sofosbuvir and velpatasvir x 12 weeks

Question 9

What is tx for tx naive pt with cirrhosis in genotype 1a?

Answer 9

Glecaprevir/pibrentasvir for 12 weeks with food

any for 12 weeks

Question 10

Which gentoype requires resistance associated substitution testing?

Answer 10

Genotype 3

Question 11

What is tx for genotype 2 without cirrhosis?

Answer 11

glecaprevir/pibrentasvir x 8 weeks with food

Sofosbuvir and velpatasvir x 12 weeks

Question 12

What is tx for genotype 2 with cirrhosis?

Answer 12

Sofosbuvir and velpatasvir x 12 weeks

Question 13

What is tx for genotype 3 without cirrhosis?

Answer 13

glecaprevir/pibrentasvir x 8 weeks with food

Sofosbuvir and velpatasvir x 12 weeks

Question 14

What is tx for genotype 3 with cirrhosis?

Answer 14

glecaprevir/pibrentasvir x 12 weeks with food

Sofosbuvir and velpatasvir x 12 weeks

Question 15

What is tx for genotype 4 without cirrhosis?

Answer 15

glecaprevir/pibrentasvir x 8 weeks with food

Sofosbuvir and velpatasvir x 12 weeks

Question 16

What is tx for genotype 4 with cirrhosis?

Answer 16

Sofosbuvir and velpatasvir x 12 weeks

Question 17

What is tx for genotype 5 and 6 without cirrhosis?

Answer 17

glecaprevir/pibrentasvir x 8 weeks with food

Question 18

What is tx for genotype 5 and 6 with cirrhosis?

Answer 18

glecaprevir/pibrentasvir x 12 weeks with food

Question 19

What is tx for genotype 1b without cirrhosis?

Answer 19

Elbasvir-grazoprevir x 12 weeks
glecaprevir/pibrentasvir x 8 weeks with food
sofosbuvir ledipasvir X 12 weeks
sofosbuvir and velpatasvir x 12 weeks

Question 20

What is USPSTF recommeded screening for Hep C?

Answer 20

All ages 18-79 without known liver disease

Question 21

What is the most common phenotype for HCV infection?

Answer 21

Genotype 1 A

Question 22

What is tx for genotype 1b with cirrhosis?

Answer 22

Elbasvir-grazoprevir x 12 weeks
glecaprevir/pibrentasvir x 12 weeks with food
Ledipasvir sofosbuvir X 12 weeks
Sofosbuvir and velpatasvir x 12 weeks

Question 23

What is black box warning of Ribavirin?

Answer 23

cannot be taken by pregnant women or by the male partners

-need to use two forms of birth control

Question 24

What is black box warning for Protease Inhibitors?

Answer 24

interfere with hormonal birth control need to use condom and diaphragm plus spermicidal jelly

Question 25

What is an alternative tx for genotype 3 with cirrhosis?

Answer 25

sofosbuvir and veltaspevir x 12 week and add ribavirin

Question 26

What are ADE of ebasvir and grazoprevir?

Answer 26

avoid CYP34A inducers

fatigue, HA, nausea

Question 27

What is ADE glecoprevir and pibrentasvir?

Answer 27

diarrhea

avoid rifampin and afazanivir

Question 28

What is ADE of ledipasvir and sofosbuvir?

Answer 28

insomnia, depression, myalgia, cough, dyspnea

Question 29

What is ADE of sofosbuvir and veltapasvir?

Answer 29

rash