Muscle Path Quiz 4

Question 1

microscopic view of muscle atrophy (disuse atrophy)

Answer 1

diminished uptake of stain
diminished muscle mass
adipose tissue increases

Question 2

the most common and one of the most serious forms of muscular dystrophy

Answer 2

Duchenne’s

Question 3

Duchenne’s is also called what? why is it called this?

Answer 3

pseudohypertrophy

because it looks like they have muscular calves, but muscle gets replaced by fat

Question 4

Duchenne’s is due to a defective gene on the X chromosome that leads to an inability to produce which protein?

Answer 4

dystrophin

Question 5

inability to produce dystrophin in Duchenne’s leads to what?

Answer 5

excess calcium enters cell causing cell death

Question 6

An _______, Duchenne’s occurs almost exclusively _________

Answer 6

X-linked recessive disease; in boys

Question 7

Myasthenia gravis is caused by

Answer 7

Abs that block Ach receptors

Post-synaptic

Question 8

muscle weakness that worsens during periods of activity and improves after periods of rest is the hallmark for which disease?

Answer 8

Myasthenia gravis

Question 9

thymoma is a rare tumor of the thymus gland associated with which condition?

Answer 9

Myasthenia gravis

Question 10

which lab is routinely done in myasthenia gravis?

Answer 10

serum anti-acetylcholine receptor antibodies

Question 11

Lambert-Eaton syndrome is associated with which cancer?

Answer 11

small cell lung cancer

Question 12

Lambert-Eaton syndrome is caused by

Answer 12

Abs that block calcium channels

pre-synaptic

Question 13

in Lambert-Eaton syndrome, the pre-synaptic block of calcium channels has what effect?

Answer 13

prevents release of Ach

Question 14

Lymphocytes invade a myofiber in this skeletal muscle biopsy from a patient diagnosed with

Answer 14

Dermatomyositis

Question 15

In dermatomyositis, a characteristic __________ rash is usu present

Answer 15

periorbital heliotrope

Question 16

Another type of rash associated with dermatomyositis is termed_________
shows up on dorsum of hands

Answer 16

Gotrron’s sign

Question 17

what’s a poor prognostic sign for polymyositis?

Answer 17

dysphagia

Question 18

microscopic view of polymyositis reveals

Answer 18

Muscles fibers appear pale & enlarged

cellular invasion by macrophages

Question 19

The biopsy appearance of inclusion body myositis is characterized by

Answer 19

focal areas of WBCs that invade muscle cell
vacuoles
amyloid-related protein
inclusions

Question 20

Rhabdomyomas are benign tumors of what type of muscle?

where are they found

Answer 20

• striated muscle

- head and neck

Question 21

the most common soft tissue tumor in children

Answer 21

Rhabdomyosarcoma