CNS Path Quiz 6 part 1

Question 1

Neurosyphilis is caused by

Answer 1

treponema pallidum

Question 2

There are several types of neurosyphilis. what are they and what are the pertinent features?

Answer 2

Meningovascular syphilis- perivascular inflammation in brain
Paretic syphilis- widespread parenchymal invasion
Tabes dorsalis- ataxia and proprioception *

Question 3

Most common presentation of meningiovascular syphilis is?

Answer 3

a stroke occurring in a young adult

Question 4

Tabes dorsalis is a form of neurosyphilis involving…?

Answer 4

the posterior column

Question 5

Neurosyphilis often results in the formation of meningeal granulomas known as

Answer 5

gummas

Question 6

A gumma results from

Answer 6

a cell-mediated immune response to Treponema

Question 7

which of the following organisms can have the Jarish-Herxhemier rxn?

Answer 7

syphilis (treponema pallidum)

Question 8

Jarisch-Herxheimer reaction occurs

Answer 8

following treatment of syphilis

Question 9

Subacute sclerosing panencephalitis (SSPE) is associated with

Answer 9

rubeola

it occurs 1-20+ yrs after measles

Question 10

Subacute sclerosing panencephalitis would show a normal CSF profile, unless you specifically ordered which test?

Answer 10

Rubeola IgG Antibody

Question 11

microscopic appearance of subacute sclerosing panencephalitis

Answer 11

eosinophilic inclusion bodies

Question 12

most notable polio sx

Answer 12

flaccid paralysis

Question 13

After a period of viremia, the polio virus becomes neurotropic and produces destruction of the

Answer 13

motor neurons in the anterior horn and brainstem

Question 14

the rabies virus travels

Answer 14

via the peripheral nerves from the site of the bite to the brain

Question 15

death from rabies usually occurs within a week due to

Answer 15

cardiac or respiratory failure

Question 16

what is 100% diagnostic for rabies (if present)?

Answer 16

Negri bodies

inclusion bodies within neurons

Question 17

what are frequent sites of attack for rabies virus?

Answer 17

Temporal lobe neurons and cerebellar Purkinje cells

Question 18

the frequency of AIDS dementia complex (ADC) increases as

Answer 18

CD4+ cell counts decrease

Question 19

In AIDS dementia, macrophages are infected and wind up in the brain. Macrophages release substance that can be toxic. like what?

Answer 19

quinolinic acid
cytokines
other signal molecules
infected macrophages can shed gp120

Question 20

what is Reye’s syndrome?

what causes it?

Answer 20

fatty infiltration of the liver and swelling of the kidneys and brain
caused by treating chicken pox with aspirin

Question 21

two main forms of spongiform encephalopathy?

Answer 21

Kuru

Creutzfeldt-Jakob disease (CJD)

Question 22

there’s a causal relationship between which two prion diseases?

Answer 22

bovine spongiform encephalopathy and variant Creutzfeldt-Jakob diseases (vCJD)