Endocrine Path Quiz 3- part 5

Question 1

Lab Criteria for dx DM

Answer 1

• Confirmed fasting blood glucose > 126 mg/dl
• A non-fasting blood glucose of > 200 mg/dL
• A positive oral glucose intolerance test (OGTT) resulting in a blood glucose > 200 mg/Dl at 2-3 hrs following a glucose bolus
• Hgb A1C > 6.5%

Question 2

which of the following is a diabetes as the result of an autoimmune disease?

Answer 2

Type 1 DM

Question 3

which two antibodies should be detectable in Type 1 DM?

Answer 3

• islet cell antibodies

- anti-insulin antibodies

Question 4

most islet cell antibodies are directed against ________ within pancreatic beta cells

Answer 4

glutamic acid decarboxylate (GAD)

Question 5

Type ____ leads to beta cells being burnt out due to insulin resistance such that you eventually you no longer produce insulin, or minimal levels, but negligible _____ found

Answer 5

2; Abs

Question 6

microscopic view of islet of langerhans shows ______ in type 1 DM

Answer 6

leukocytic infiltration

Question 7

common changes seen in islet cells in type 2 DM?

Answer 7

hyalinization with deposition of amyloid

Question 8

The longer a person has diabetes, the higher his or her chances of developing

Answer 8

diabetic retinopathy

Question 9

The earliest detectable visible change in the course of diabetic nephropathy is

Answer 9

thickening of the capillaries within the glomerulus

Question 10

Zollinger–Ellison syndrome

Answer 10

multiple peptic ulcers in the stomach and duodenum

Question 11

An insulinoma is a tumor occurring where?

Answer 11

pancreatic tumor derived from beta cells

Question 12

Gastrinoma secretes excess gastrin leading to

Answer 12

excess HCl (sx: ulcers in stomach, duodenum and SI and diarrhea)

Question 13

what turns out to be the cause of Zollinger-Ellison syndrome?

Answer 13

Gastrinomas