Endocrine Path Quiz 3- part 4 Flashcards
adrenal cortex secretes which 3 hormones?
glucocorticoids (cortisol) mineralocorticoids (aldosterone) sex hormones (DHEA)
overproduction of the hormones produces by the adrenal cortex is most likely due to what?
adenoma
major hormone produced by adrenal medulla?
epinephrine (aka adrenalin)
also produce nor-epinephrine and dopamine
aldosterone is under control by which system?
renin-angiotensin system (rather than H-P axis)
primary hyperaldosteronism aka ________
usu due to ________
Conn’s syndrome
adenoma
often the only clinic sign of Conn’s is
hypertension (due to hypernatremia)
important lab findings of Conn’s
High serum aldosterone
Low serum potassium and high serum sodium
Decreased plasma renin (suppressed by elevated aldosterone level)
what’s causing the excess cortisol production seen in Cushing’s?
pituitary tumors secreting excess ACTH
happening at level of brain NOT adrenals!!!
what is a manifestation of Cushing’s?
hyperglycemia
what’s causing the low cortisol levels seen in Addison’s disease?
primary?
secondary?
primary = adrenal gland itself damaged. secondary= insufficient ACTH results in atrophy of adrenal cortex
The most common cause of primary Addison’s disease is
autoimmune destruction of the adrenal cortex
what clinical presentation is seen with primary Addison’s?
why?
- Hyperpigmentation
- with increased ACTH production stimulate melanocytes to produce more melanin
trauma or adrenal hemorrhage from sepsis is called?
waterhouse-frederickson syndrome
how is the condition waterhouse-frederickson syndrome related to Addison’s?
disrupts normal function of adrenal gland
considered a secondary cause of Addison’s dz
how to distinguish primary from secondary Addison’s disease?
primary - hyperpigmentation
secondary- skin pallor
