Muscle Histology II Flashcards

1
Q

Each myofiber is connected to a motor _______.

A

Neuron

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2
Q

What is the chemical neurotransmitter for skeletal muscle? (Full name and abbreviation)

A

Acetylcholine, ACh

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3
Q

A myofiber only contracts when stimulated by its nerve

Motor______ _____.

A

End Plate

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4
Q

At the end plate, the sarcolemma is extensively ______ to increase _______ ________.

A

Folded

Surface Area

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5
Q

What purpose does the motor end plate serve?

A

Provides a large surface area for millions of ACh receptors

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6
Q

What is a graded response with skeletal muscle?

A

Our muscle contractions are relatively smooth and can vary in strength as different demands are put on them. Variations in the degree of a muscle contraction are referred to as graded responses.

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7
Q

What does innervation ratio mean in the context of skeletal muscle?

A

The ratio of motor neurons to muscle fibers

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8
Q

What is an example of an innervation ratio for fine control?

A

Muscles for the eyes; 1:8 ratio

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9
Q

What is an example of an innervation ratio for strength an power?

A

Quad; 1:2,000 ratio

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10
Q

What is muscle recruitment?

A

To increase contractile power, more units are stimulated

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11
Q

Muscle units of a single motor unit are not clustered all together, but are dispersed throughout the _______ ______.

A

Whole muscle

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12
Q

When muscles are stimulated, this causes a _____ contraction over a wide area, not a localized twitch in a small region.

A

Weak

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13
Q

What is an advantage of multiple motor units within a muscle?

A

They are “able to work in shifts.” Muscle fibers fatigue when subjected to continued stimulation, and so other motor units take over while fatigued ones rest.

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14
Q

In muscle contraction, or the “sliding mechanism” what structures shorten?

A

Myofiber

Myofibrils

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15
Q

What defined area shortens during the “sliding” mechanism?

A

The sarcomere, or area from Z line to Z line

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16
Q

What structures do not shorter, but rather slide by each other?

A

Myofilaments

17
Q

Crossbridging takes place between ______ and ________.

A

Actin

Myosin

18
Q

When does crossbridging take place? When working or at rest.

A

When the muscle is at work.

19
Q

How do myosin and actin crossbridge?

A

Myosin has a “head” portion that attaches to and then detaches from actin, allowing them to slide by each other

20
Q

What two molecules essential for crossbridging?

A

ATP and Ca++

21
Q

What is stored in the terminal cisternae?

A

Ca++

22
Q

How is Ca++ put back into the terminal cisternae?

A

By active transport

23
Q

Why is Ca++ stored in the terminal cisternae?

A

To assist with muscle contraction

24
Q

What 3 proteins make up actin?

A

F actin
Tropomyosin
Troponin

25
Q

What is F Actin made from?

A

A string of 200+ G actins

26
Q

What is G actin?

A

A bean-shaped polypeptide with an active site

27
Q

What is tropomyocin?

A

2 protein strands spiralled around 2 strands of F actin

28
Q

What shape is tropomyosin?

A

Rod-shaped

29
Q

Troponin is a 3 _______ complex

A

polypeptide

30
Q

What is troponin attached to?

A

Tropomyosin

31
Q

What is the site for Ca++ attachment in actin?

A

Troponin

32
Q

What are the two regulatory proteins in actin?

A

tropomyosin

troponin

33
Q

What happens when Ca++ binds to troponin?

A

When Ca++ is present, it binds to troponin, and this makes the tropomyosin “move away” from the active sites. It uncovers the active site on the F actin, allowing the myosin heads to attach to the F actin active sites.

So, it allows for contraction.

34
Q

When myofibrils are sliding past each other, the heads of the ______ must disconnect from _____.

A

Myosin

Actin

35
Q

Myosin is a ____-shaped protein with 2 ______.

A

Rod-shaped

2 heads

36
Q

What two compounds are found on the heads of myosin?

A

ATP binding sites and ATPase

37
Q

The head of myosin allows for ___________ with actin.

A

Crossbridging

38
Q

The heads of myosin are not present in the ___ zone.

A

H zone

39
Q

When muscle is at rest, the heads of myosin _____ attached.

A

aren’t