mucosal immunity Flashcards
what are cytokines
Cytokines are chemical mediators that regulate cell immune responses
gastrointestinal mucosa
The gastrointestinal tract represents a major site of host-environment (luminal contents) interaction
how many cells thick is the gastrointestinal epithelial barrier
1
features of the GI epithelial barrier
rapid restitution to retain continuity, selective permeability of water, ions, nutrients
secretory function of GI epithelial barrier
innate immunity – cytokines, antimicrobial peptides
what do MUC proteins do
create a latus shape for mucus to stick to
what do goblet cells do
make mucus
where are the immune cells
in lamina propria
what do payers patches do
Detect luminal contents and recognise commensal microbes as ‘good bacteria’ (tolerance) from pathogens that require robust immune response
what does the GI epithelium develop
self tolerance, exogenous tolerance (food, microbes), develop an effective immune response
what are ICE
intestinal epithelial cells
how do microbes impact on ICE
ICE express pattern recognition receptors. stimulate AMP secretion and cytokine responses. they sense microbial metabolites (what pathogens secret)
