intro to embryology Flashcards

1
Q

weeks 0-3

A

conceptus/embryo

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2
Q

weeks 3-8

A

embryonic period. critical time most problems occur also the most development

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3
Q

weeks 9-40

A

foetal period. growth rather than development

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4
Q

phases of embryogenesis

A
  1. Gametogenesis
  2. Fertilisation
  3. Cleavage
  4. Gastrulation
  5. Formation of a body plan
  6. Organogenesis
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5
Q

what is gametogenesis

A

formation of a gamete. consisting of mitosis and meiosis leading to genetic variation

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6
Q

what is a gamete

A
  • A gamete is a cell with a complement of 23 chromosomes (half of a typical somatic cell)
  • Haploid (23 chromosomes)
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7
Q

what id oogenesis

A

formation of female gamete

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8
Q

when does oogenesis take place

A
  • Starts in development (of embryo) and ends at menopause.
  • By week 28-30: Primary oocytes begin meiosis but arrest in prophase until puberty.
  • Reproductive life span determined in fetal life (already has all eggs from birth)
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9
Q

spermatogenesis

A
  • Formation of male gametes
  • Occurs at puberty and continues throughout life - Each cycle takes ~64-74 days
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10
Q

production rate of spermatogenesis

A
  • Production rate: ~6.5 million sperm per gram of testicular tissue/day. Decreases with age
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11
Q

who determines sex of baby

A

males. * Outcome 22+X or 22+Y

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12
Q

trisomy 21

A

additional copy of chromosome 21. typically caused by nondisjunction

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13
Q

when does nondisjunction typically occur

A

75% of nondisjunction occurs during oocyte formation

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14
Q

fertilisation

A

union of gametes. fusion of sperm and oocyte

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15
Q

cleavage

A
  • Period of rapid mitotic cell division
  • No increase in size
  • Formation of Morula then Blastocyst (blastocyte splits into 2 parts 1 forming the placenta the other forming the embryo)
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16
Q

what is a blastomere

A

an individual cell

17
Q

what is a morula

A

multiple blastomeres

18
Q

gastrulation

A

formation of germ layers (week 3). body axes established

19
Q

what 3 layers are formed during gastrulation

A

Ectoderm (outer, forms skin and other) , Mesoderm (forms muscles nd skeleton), Endoderm (inner, forms GI tract ect)

20
Q

how does the formation of a body plan happen

A

embryonic folding (tube within a tube)

21
Q

organogenesis

A
  • Formation of Organs and Organ Systems
  • Basis of these all-in place by end of embryonic period
  • Will continue to develop through foetal period
22
Q

foetal period

A

growth and weight gain. grows in 2nd trimester. weight gain in 3rd. overt sexual differentiation. bones laid down and connections made in CNS

23
Q

orientation of foetus

A

top = cranial. back = dorsal. front - ventral. bottom = caudal

24
Q

primary processes. zygote to human

A

cell division. differentiation. cell attachment. apoptosis. induction. cell migration

25
Q

cell division

A

increase in number of cells

26
Q

differentiation

A

specialisation, change in appearance/structure, adoption of new functions

27
Q

cell attachment

A

physical/functional linkages, formation of tissue

28
Q

apoptosis

A
  • Programmed cell death
29
Q

induction

A
  • Induction. Ability of one cell type to cause another to differentiate (directly or from distance)
30
Q

cell migration

A

movement from one location to another

31
Q

secondary processes

A

axis formation, folding/rotation

32
Q

axis formation

A

Which way is up? Cells need to know where they are in relation to each other and embryo as whole

33
Q

folding/rotation

A

Forms entire embryo and structures within. Gives embryo 3D form. Allows the formation of complex organ structures eg heart, gut

34
Q

control of development

A
  • Genetic. Gene expression, tightly regulated
  • Epigenetic. Preferential expression of maternal or paternal copy of gene
  • (environmental)