mt.2 Antigen Antibody Lec 6 (IgA, M, E, D) Flashcards
what immunoglobulin is in the highest concentrations in secretions?
IgA
How big is IgA in blood and secretions?
Molecular weight 150,000 daltons in blood/300,000 daltons in secretions
what are the sub-classes of IgA?
two sub-classes: IgA1, IgA2
Monomeric or dimeric IgA in blood? in secretions?
- blood= Monomeric (2 antigen binding sites)
* secretions= Dimeric (4 antigen binding sites)
IgA can or cannot fix complement?
canNOT
IgA can or cannot cross placenta?
canNOT
IgA prevents adherence of microbes where?
at secretory surfaces of oral cavity, lung, nasal cavity, eyes, gastrointestinal tract, genitourinary tract
Where is IgA secreted?
In the salivary gland, beneath the ductal epithelium lie plasma cells that secrete dimeric IgA
What immunoglobulin has the highest molecular weight?
IgM at 900,000daltons
what are the sub-classes of IgM?
there are none. ONE CLASS
what is the shape of IgM?
pentameric
what does IgM being pentameric mean?
ten antigen binding sites
IgM can or cannot fix complement?
CAN
what immunoglobulins can fix complement?
IgG and IgM
IgM is first produced during?
primary immune response
Monomeric or pentameric IgG in secretions? at cell surface?
- secreted= pentameric
* cell surface= monomeric
what immunoglobulin is the reaginic antibody?
IgE
what is the last immunoglobulin dicovered?
IgE
IgE is found in higher concentration in poeple with?
allergies (low otherwise)
what are the sub-classes of IgE?
there are none. ONE CLASS
IgE can or cannot fix complement?
canNOT
IgE can or cannot enhance phagocytosis?
canNOT
IgE can or cannot bind to histamine rich
basophils or mast cells?
can
How do IgE bind to bind to histamine rich
basophils or mast cells?
via Fc-Epsilon receptors that bind to the Fc region
what are the sub-classes of IgE?
there are none. ONE CLASS
What immunoglobulins have only ONE class?
IgM, IgE, IgD
Does IgD have high or low populations in blood?
low
IgD is only found on the surface of?
mature B cells
If IgD is only found on the surface of mature B cells, how is there Free IgD in the blood?
probably sheared off of B cells to get into blood
IgD is NOT made by what type of cell?
plasma cells
