5.2 Cells N Tissues Adapt Immunity Spleen Flashcards
Spleen is another secondary lymphoid organ where antigen enters from?
the blood stream via the central arteriole of the spleen
Spleen has ___ and ____ pulp?
red and white pulp
red pulp of spleen is populated with?
with red blood cells, macrophages, and plasma cells
white pulp of spleen is populated with?
with lymphocytes that generate an immune response
*where we have follicles in spleen
Spleen has follicles along the?
central arterioles
T cell area of spleen adjacent to the central arteriole is the?
periarteriole lymphoid sheath
B cell area with germinal centers of spleen are in the center of the T cell area but?
separate
plasma cells migrate to the?
red pulp and bone marrow
Common mucosal immune system provide immunity to?
mucosal surfaces
Common mucosal immune system mucosal surfaces are constantly exposed to?
to the environment, including microbes
Compare # of lymph nodes vs spleen
Hundreds of lymph nodes
*typically onely ONE spleen
What is BALT?
What is GALT?
- Bronchus associated lymphoid tissue
- Gut associated lymphoid tissue
- **BOTH are branches of common mucosal immune system
Immunity at one point in the GALT or BALT tissue is shared by?
all points in these tissue
Adaptive immunity-the GALT pathway?
**KNOW
1) M cells of Peyer’s patches of the Ileum
2) Follicles of Peyer’s patches
3) Mesenteric lymph nodes
4) Thoracic duct lymph
5) Blood circulation
6) Spleen
7) Circulation
8) salivary gland, lamina propria, lacrimal gand, mammary gland, genito/urinary tract
Where are Peyer’s patches found?
found along the small intestine (ileum) ~400
Each Peyer’s patche has a dome of cells with?
T and B cells mixed together
What is below the dome of cells in Peyer’s patches?
every dome of cells has follicles containing B cells (mostly) in it
In Peyer’s Patches, the B cell follicles have?
germinal center with ongoing immune response
Where are T-cells located in Peyer’s Pathces?
1) perifollicular area contains T cells except
2) some T cells are in the germinal center
B cells in intestine that are going to become plasma cells migrate out of?
Peyer’s patches via the GALT pathway
once B cells migrate out Peyer’s Patchs and become plasma cells, where do they go?
end up in the salivary gland, lacrimal (tears) gland, lamina propria of small intestine or any other mucosal secretory sites
Microfold (M) cells are a type of _____ cell
epithelial
Microfold (M) cells present or found where?
among the villous epithelium of the small intestine
Each M-cell is vigorous in _____ and _____
phagocytosis and transcytosis
Microfold (M) cells uptake what? Then do what?
*main function?!?
luminal antigens such as bacteria. Then deliver the antigens to the immune cells in GALT for initiation of gut immune response
*CAPTURE stuff via phagocytosis and transcytosis
M cells are not covered by?
mucous layer (makes them more susceptible to pathogens= good and bad thing)
What is ‘interesting’ about GALT and BALT?
they are the initial cites for immune responses BUT the END points for the effector antibodies that are coming out (meaning the information coming from either is shared at all the different cites of the body)
99% of B plasma cells in GALT system are making what antibody?
IgA
