5.3 Cells N Tissues Adapt Immunity

Question 1

The actual secretion of IgA takes place in?

Answer 1

salivary gland and lacrimal gland at SUBEPITHELIAL locations

Question 2

In the end, secretory IgA is composed of ?

Answer 2

dimeric IgA-Jchain Secretory component

Question 3

What are the 4 tonsil types?

Answer 3

• Palatine- sides of throat, most prominent
• Pharyngeal (adenoids)
• Tubal - near eustacian tubes
• Lingual -back of tongue

Question 4

What are tonsils?

Answer 4

they are secondary lymphoid tissue/structures but are NOT a lymph node

Question 5

Where are the tonsil located?

Answer 5

located between the mouth and pharynx embedded between the glossopalatine and pharyngopalatine arches

Question 6

What type of lymphatics does the tonsils have?

Answer 6

ONLY efferent lymphatics

*there are no afferent lymphatics

Question 7

How does an antigen gain entry into the tonsils? It’s taken up by?

Answer 7

Antigen gains entry through the BASE of CRYPT epithelium and then antigen is taken up by macrophages

Question 8

What transports antigens once they gain entry at the tonsils?

Answer 8

macrophages

Question 9

macrophages transport antigen to the ______ area or antigen enters ______?

Answer 9

T cell area or antigen enters follicle of B cell area

Question 10

Gingival domain contains ____ lymphocytes? this supports immunity where?

Answer 10

contains EFFECTOR lymphocytes that support immunity at the gingiva

Question 11

Gingival domain acquired Immunity is provided by what nodes?

Answer 11

lymph nodes of the head and neck

Question 12

What Ig predominates at Gingival domain?

Answer 12

IgG (in gingival crevicular fluid!)

*mediates many activities

Question 13

What does IgG mediate?

Answer 13

mediates opsonization, complement mediated lysis, and prevention of microbe attachment

Question 14

Neutrophil phagocytosis is enhanced by? via?

Answer 14

opsonization via IgG

Question 15

What is VERY present in the gingival domain?

Answer 15

Complement is present

Question 16

In the gingival domain, complement is present and mediates?

Answer 16

1) microbe lysis
2) chemotaxis of leukocytes
3) mast cell degranulation
4) more opsonization via classical and alternate pathways

Question 17

Extra oral lymph nodes-provide immunity to ______ _____ fluid?

Answer 17

gingival crevicular fluid

Question 18

What is gingival crevicular fluid?

**must know

Answer 18

blood fluid that enters lamina propria via junctional epithelium

Question 19

gingival crevicular fluid enters lamina propria as a result of?

Answer 19

inflammation induced by microbial accumulation at the junctional epithelium

Question 20

Does gingival crevicular fluid flow exist without inflammation?

Answer 20

Probably some

Question 21

gingivitis or periodontitis are examples of? Cause what?

Answer 21

types of inflammation of the oral cavity that allow for blood fluid that enters lamina propria via junctional epithelium (aka gingival crevicular fluid)

Question 22

what are the molecular components of gingival crevicular fluid?

Answer 22

1) IgG
2) IgA (MONOMERIC)
3) IgM
4) complement components
5) immune complexes
6) albumin
7) transferrin

Question 23

what are the cellular components of gingival crevicular fluid?

Answer 23

neutrophils, macrophages, T and B lymphocytes

Question 24

• *What are the 4 fates of antigen that enters in or on the body?
  1. blood
  2. epidermal
  3. oral
  4. respiratory

Answer 24

1. Antigen in Blood stream -goes to spleen
2. Antigen at Epidermal, dermal, subcutaneous, gingival site -goes to afferent lymphatics
3. Oral antigen - goes to gut associated lymphoid tissue.
4. Respiratory antigen- Bronchial associated
   lymphoid tissue

Question 25

first two steps of circulation of lymphocytes?

Answer 25

- -1. Entry of lymphocytes to lymph node or Peyer's patches through post capillary venules at lymph node which have specialized high endothelial venules with adhesion molecules specifically for lymphocytes - -2. Entry to spleen through hilus to trabecular artery

Question 26

last two steps of circulation of lymphocytes?

Answer 26

- -3. Exit lymph node through efferent lymphatics | - -4. Exit spleen through trabecular vein or efferent lymphatics of spleen

Question 27

What is the salvitory gland? MUST REMEMBER

Answer 27

IgA based immunoglobulin antibody | **DIMERIC!!!! IT IS DIMERIC IN SALIVA and monomeric in gingival crevicular fluid

Question 28

what are the 3 main oral lymphoid tissue structures?

Answer 28

salivary glands tonsils gingiva

Question 29

crypt epithelium is very prominent on what tonsil type?

Answer 29

palatine

Question 30

Where are plasma cells located for tonsils?

Answer 30

in a cap or corona on the outside of outer T-cell layer of the follicular structure

Question 31

The tonsils are mainly what type of Ig? | Purpose?

Answer 31

IgG!!! *IgG also LEAVES through the crypt epithelium to coat the back of throat! Isn't meant to protect oral cavity, meant to protect throught/pharynx

Question 32

What is different about the gingival domain compared to other lymph tissue?

Answer 32

It is NOT organized

Question 33

IgG is dominant in?

Answer 33

gingival crevicular fluid AND tonsils!

Question 34

How is gingival crevicular fluid different from saliva?

Answer 34

It has IgG (not IgA) and neutrophils aka inflammatory cells

Question 35

How do you stimulate the gingival domain?

Answer 35

extra oral lymph nodes with drainage from head and neck

Question 36

antibody in gingival crevicular fluid is a reflection of _______ immunity?

Answer 36

systemic immunity

Question 37

Long explanation of 'extra oral lymph nodes-provide immunity to gingival cervicular fluid'. It is in 8 steps... Also find this on iPad under Quiz 5 notes... just don't forget it

Answer 37

* 1. To stimulate an immune response at an extra oral lymph node, antigen enters at the end of lymph capillaries in the mucosa of tongue, floor of mouth, palate cheeks, lips, gingiva, pulp of the teeth * 2. Then antigen drains via afferent lymphatics into submandibular, submental, upper deep cervical, retropharyngeal extra oral lymph nodes * 3. immune responses are generated in germinal centers and paracortex (T cell areas) of these extra oral lymph nodes * 4. antibody is secreted by B plasma cells into efferent lymphatics of * 5. antibody then enters blood circulation * 6. antibody then enters into gingival lamina propria via capillaries of gingiva * 7. antibody percolates into gingival crevicular fluid. * 8. therefore antibody in gingival crevicular fluid is a reflection of systemic immunity