5.3 Cells N Tissues Adapt Immunity Flashcards
The actual secretion of IgA takes place in?
salivary gland and lacrimal gland at SUBEPITHELIAL locations
In the end, secretory IgA is composed of ?
dimeric IgA-Jchain Secretory component
What are the 4 tonsil types?
- Palatine- sides of throat, most prominent
- Pharyngeal (adenoids)
- Tubal - near eustacian tubes
- Lingual -back of tongue
What are tonsils?
they are secondary lymphoid tissue/structures but are NOT a lymph node
Where are the tonsil located?
located between the mouth and pharynx embedded between the glossopalatine and pharyngopalatine arches
What type of lymphatics does the tonsils have?
ONLY efferent lymphatics
*there are no afferent lymphatics
How does an antigen gain entry into the tonsils? It’s taken up by?
Antigen gains entry through the BASE of CRYPT epithelium and then antigen is taken up by macrophages
What transports antigens once they gain entry at the tonsils?
macrophages
macrophages transport antigen to the ______ area or antigen enters ______?
T cell area or antigen enters follicle of B cell area
Gingival domain contains ____ lymphocytes? this supports immunity where?
contains EFFECTOR lymphocytes that support immunity at the gingiva
Gingival domain acquired Immunity is provided by what nodes?
lymph nodes of the head and neck
What Ig predominates at Gingival domain?
IgG (in gingival crevicular fluid!)
*mediates many activities
What does IgG mediate?
mediates opsonization, complement mediated lysis, and prevention of microbe attachment
Neutrophil phagocytosis is enhanced by? via?
opsonization via IgG
What is VERY present in the gingival domain?
Complement is present
In the gingival domain, complement is present and mediates?
1) microbe lysis
2) chemotaxis of leukocytes
3) mast cell degranulation
4) more opsonization via classical and alternate pathways
Extra oral lymph nodes-provide immunity to ______ _____ fluid?
gingival crevicular fluid
What is gingival crevicular fluid?
**must know
blood fluid that enters lamina propria via junctional epithelium
gingival crevicular fluid enters lamina propria as a result of?
inflammation induced by microbial accumulation at the junctional epithelium
Does gingival crevicular fluid flow exist without inflammation?
Probably some
gingivitis or periodontitis are examples of? Cause what?
types of inflammation of the oral cavity that allow for blood fluid that enters lamina propria via junctional epithelium (aka gingival crevicular fluid)
what are the molecular components of gingival crevicular fluid?
1) IgG
2) IgA (MONOMERIC)
3) IgM
4) complement components
5) immune complexes
6) albumin
7) transferrin
what are the cellular components of gingival crevicular fluid?
neutrophils, macrophages, T and B lymphocytes
- *What are the 4 fates of antigen that enters in or on the body?
1. blood
2. epidermal
3. oral
4. respiratory
- Antigen in Blood stream -goes to spleen
- Antigen at Epidermal, dermal, subcutaneous, gingival site -goes to afferent lymphatics
- Oral antigen - goes to gut associated lymphoid tissue.
- Respiratory antigen- Bronchial associated
lymphoid tissue
first two steps of circulation of lymphocytes?
- -1. Entry of lymphocytes to lymph node or Peyer’s patches through post capillary venules at lymph node which have specialized high endothelial venules with adhesion molecules specifically for lymphocytes
- -2. Entry to spleen through hilus to trabecular artery
last two steps of circulation of lymphocytes?
- -3. Exit lymph node through efferent lymphatics
- -4. Exit spleen through trabecular vein or efferent lymphatics of spleen
What is the salvitory gland? MUST REMEMBER
IgA based immunoglobulin antibody
**DIMERIC!!!! IT IS DIMERIC IN SALIVA and monomeric in gingival crevicular fluid
what are the 3 main oral lymphoid tissue structures?
salivary glands
tonsils
gingiva
crypt epithelium is very prominent on what tonsil type?
palatine
Where are plasma cells located for tonsils?
in a cap or corona on the outside of outer T-cell layer of the follicular structure
The tonsils are mainly what type of Ig?
Purpose?
IgG!!!
*IgG also LEAVES through the crypt epithelium to coat the back of throat! Isn’t meant to protect oral cavity, meant to protect throught/pharynx
What is different about the gingival domain compared to other lymph tissue?
It is NOT organized
IgG is dominant in?
gingival crevicular fluid AND tonsils!
How is gingival crevicular fluid different from saliva?
It has IgG (not IgA) and neutrophils aka inflammatory cells
How do you stimulate the gingival domain?
extra oral lymph nodes with drainage from head and neck
antibody in gingival crevicular fluid is a reflection of _______ immunity?
systemic immunity
Long explanation of ‘extra oral lymph nodes-provide immunity to gingival cervicular fluid’. It is in 8 steps… Also find this on iPad under Quiz 5 notes… just don’t forget it
- To stimulate an immune response at an extra oral lymph node, antigen enters at the end of lymph capillaries in the mucosa of tongue, floor of mouth, palate cheeks, lips, gingiva, pulp of the teeth
- Then antigen drains via afferent lymphatics into submandibular, submental, upper deep cervical, retropharyngeal extra oral lymph nodes
- immune responses are generated in germinal centers and paracortex (T cell areas) of these extra oral lymph nodes
- antibody is secreted by B plasma cells into efferent lymphatics of
- antibody then enters blood circulation
- antibody then enters into gingival lamina propria via capillaries of gingiva
- antibody percolates into gingival crevicular fluid.
- therefore antibody in gingival crevicular fluid is a reflection of systemic immunity
