MSI Mucosal Immunology Flashcards
Important inductive sites incude the Peyer’s patches and ____________ lymph nodes.
mesenteric
What are the two effector sites of the adaptive immune response?
Epithelium and the lamina propria
T-cells and B-cells leave PP’s via afferent lymphatics and return to the gut via the __________ and bloodstream. This cellular re-circulation pattern is referred to as _________.
thoracic duct, “homing”
This is a network of lymphoid cell aggregates and tissue that is distributed in submucosal layers of the gastrointestinal, genital, respiratory, and urinary tracts, as well as in the eyes, skin, thyroid, breasts, tonsils, and salivary glands.
Mucosa-associated lymphoid tissue(MALT)
The MALT is populated by which types of immune cells?
lymphocytes such asT cellsandB cells, as well asplasma cellsandmacrophages
What is the biggest immune compartment of the organism, harbouring 60% of all effector cells?
MALT
- _______ sites are the ports of entry for many infections and an important target site for vaccine-induced protection
Mucosal
Extensively glycosylated proteins that form a viscous barrier
mucins
Goblet cells, absorptive epithelial cells, M cells, and Paneth cells are specialised types of __________ cells
epithelial
The four main defence strategies of oropharynx and intestinal mucosa include:
- Endogenous flora
- Epithelium and Mucus
- Regionalised Immune System (incl _________ ______, PP’s, MLN’s)
- Gut homing of B and T cells
Waldyer’s ring
What are the two places where the largest amount of lymphoid tissue is found?
in the oropharynx (Waldeyer’s ring) and terminal ileum (Peyer’s patches)
Where are germinal centres for B- and T cells found?
Peyer’s patches
These are the sites where antigens sampled from mucosal surfaces stimulate cognate (ie related/connected) naive T and B lymphocytes
Inductor sites (for example, PP’s and MLN’s)
Effector sites are where the effector cells after extravasation, retention, and differentiation perform their action, for instance by contributing to the formation of __________
antibodies
What are two effector sites?
Lamina propria, intestinal epithelium
What type of cells actively transport luminal antigens to the underlying lymphoid follicles to initiate an immune response?
M cells