monoamine hypothesis dep

Question 1

what does the theory say depression is caused by?

Answer 1

an imbalance in the monoamine neurotransmitters

Question 2

what kind of imbalance takes place>?

Answer 2

a decrease

Question 3

what are the the NT involved?

Answer 3

nor-adrenaline, serotonin, dopamine

Question 4

what was noticed in the 1950s?

Answer 4

drugs that decreased these particular NT caused symptoms similar to depression

Question 5

what are the characteristics associated with nor-adrenaline?

Answer 5

sleeping, energy, motivation, emotion

Question 6

characteristics of serotonin>?

Answer 6

mood control, sleeping, hunger

Question 7

what other job does serotonin do?

Answer 7

regulates Nadrenaline

Question 8

what happens if there is a low level of serotonin?

Answer 8

low level of Nadrenaline, lack of motivation and pleasure

Question 9

characteristics of dopamine?

Answer 9

emotion, addiction, pleasure and cog function

Question 10

what does a decreased amount of dopmaine explain?

Answer 10

diminished interest and lack of pleasure

Question 11

how many weeks might drugs take to work?

Answer 11

6 weeks

Question 12

why do drugs not work straight away

Answer 12

due to a neuro-circulatory change in the brain

Question 13

what type of neuro-circulatory changes occur?

Answer 13

due to the low levels, an up regulation in sensitivity occurs on receptor sites of post synaptic neuron

Question 14

what happens when the NT suddenly become available through drugs?

Answer 14

a down regulation occurs in sensitivity, causes post synaptic neuron receptors sites to desensitise

Question 15

what did kilmeck find? (strength)

Answer 15

he compared the brain of 15 dead patients with and without depression, found that there were differences in the part of the brain that produces noradrenaline
showing that ND is involved

Question 16

what did McNeal and cimbolic find? (strength)

Answer 16

depressives show a lower level of 5HIAA which is produced when serotonin is broken down

Question 17

what does another biological explanation suggest that goes against this one?

Answer 17

suggests that part of the nervous system is involved and that increased cortisol is associated with depression, incomplete

Question 18

what doe MRI scans show about the theory?

Answer 18

there have been differences in those with and without depression, specifically a smaller hippo campus, so it is structural as well as biochemical

Question 19

what is moa-a?

Answer 19

a chemical that removes monoamine nt form the synapse when they are not needed

Question 20

what does too much moa-a mean?

Answer 20

that too much of the nt are being taken away producing symptoms of depression