Molecular Medicine Flashcards
What are the hydrophobic vitamins?
Vitamin A, D, E and K
What are the hydrophilic vitamins?
B-complex and C
Which vitamins are the hormone precursors?
A and D
Which vitamins are redox cofactors/antioxidants?
C, E, K, B2 and B3
Whih vitamins allow group transfers?
B6, B12, Biotin, Folic acid and Pantothenic acid
What are the essential fatty acids? and what are they needed for?
Omega 3 (a-linoleic) and Omega 6 (linoleic). Eicosanoids (prostaglandins, thromboxanes and leukotrienes. These molecules mediate inflammation, pain and modulate cellular activity. Non-steroidal anti-inflammatory drugs target synthesis of the eicosanoids (cyclooxygenase)
What is catabolism?
Breakdown of substances
What is anabolism?
Buildup of substances
What are the oxidoreductases?
Enzymes which catalyse oxidation-reduction reactions. e.g. cytochrome c
What are the transferases?
Enzymes which catalyse group transfers. e.g. kinases
What are the hydrolayses?
Enzymes which catalyse hydrolysis reactions. e.g. proteases
What are the lyases?
Enzymes which catalyse addition of groups to a double bond or creation of a double bond by removal of a group. e.g. Adenylate cyclase
What are the isomerases?
Enzymes which catalyse transfer of groups within a molecule. e.g. DNA topoisomerase
What are the ligases?
Enzymes which catalyse condensation reactions. e.g. DNA ligase
How is enzyme production controlled?
Negative feedback loops