Adverse Drug Reactions Flashcards
1
Q
What % of hospital admissions are due to ADRs?
A
4-6%
2
Q
What % of hospital patients suffer ADRs?
A
10-20%
3
Q
What is the difference between an overdose and an ADR?
A
An ADR happens at a therapeutic dose
4
Q
Why do ADRs occur?
A
Difference in individuals - metabolism, absorption, distribution and excretion
5
Q
Which drugs account for the most ADRs?
A
NSAIDS (29.6%)
Diuretics (27.3%)
6
Q
What are the off-target ADRs?
A
ADRs which occur due to interactions between the drug and molecules which weren’t the target.
Delayed reactions
Withdrawal
No pharmaceutical prediction
7
Q
What are the on-target ADRs?
A
Exaggeration of the drug’s normal effect due to age, genetic factors or other diseases
8
Q
How are ADRs avoided?
A
Use a familiar drug Dont prescribe unnecessarily Warn patients about ADRs Consider other disease states Start with a low dose and increase Ensure appropriate dosage Consider drug interactions Ask about allergies Avoid in certain patients
