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Immunology Quiz Questions > Module A Quiz Questions > Flashcards

Module A Quiz Questions Flashcards

1
Q

Which of these is not a cardinal sign of inflammation?
Pain
Coolness
Redness
Swelling

A

Coolness

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2
Q

Who developed a vaccine for smallpox?
Koch
Jenner
Pasteur
Fleming

A

Jenner

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3
Q

Which of these is not a secondary lymphoid tissue?
Spleen
Peyer’s patch
Thymus
Lymph node

A

Thymus

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4
Q

Who discovered that silkworm disease can be caused by a fungus?
Semmelweis
Bassi
Koch
Jenner

A

Bassi

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5
Q

Which of the following is an agranulocyte?
Mast cell
Lymphocyte
Basophil
Neutrophil

A

Lymphocyte

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6
Q

Which of these is NOT true of the innate immune system?
It has no memory
It is non-specific
It involves granulocytes
It takes 7 to 10 days to begin a response

A

It takes 7 to 10 days to begin a response

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7
Q

What does TLR-4 primarily recognize?
Lipopolysaccharide
Specific protein antigens
Bound antibodies
Viral nucleic acid

A

Lipopolysaccharide

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8
Q

What type of action do most cytokines produce?
Endocrine
Paracrine
Mesocrine
Autocrine

A

Paracrine

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9
Q

During the oxidative burst, what reactive oxygen species is produced by NADPH oxidase?
Bleach
Nitric oxide
Superoxide
Hydrogen peroxide

A

Superoxide

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10
Q

What term refers to the process where neutrophils leave circulation and enter tissues?
Phototaxis
Viropexis
Apoptosis
Diapedesis

A

Diapedesis

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11
Q

What is the main opsin in the complement cascade?
C5b
C5a
C3a
C3b

A

C3b

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12
Q

What is the function of DAF?
Stabilize C5 convertase
Stabilize C3 convertasae
Degrade C3 convertase
Degrade C5 convertase

A

Degrade C3 convertase

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13
Q

What is the main anaphylatoxin produced in the complement cascade?
C5b
C5a
C3a
C3b

A

C5a

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14
Q

Which complement cascade involves the action of MASPs?
Classical
All of them
Alternative
Lectin-binding

A

Alternative

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15
Q

Which of the complement cascades acts the fastest?
They all act at the same time
Classical
Lectin-binding
Alternative

A

Alternative

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16
Q

Which of these is the C5 convertase of the classical cascade?
C3bBb
C2b4b
C3PO
C2b4b3b

A

C2b4b3b

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17
Q

What is the function of properdin?
Degrade C3 convertase
Degrade C5 convertase
Stabilize C5 convertase
Stabilize C3 convertase

A

Stabilize C3 convertase

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18
Q

Which complement protein forms the pore in the membrane attack complex?
C6
C8
C7
C9

A

C9

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19
Q

Which of these is the C3 convertase of the alternative cascade?
C6789
R2D2
C3bBbP
C2b4B

A

C3bBbP

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20
Q

Which of these is ONLY active in the classical complement cascade?
C1
C4
C2
C3

A

C1

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21
Q

Which of these is involved in antigen presentation of extracellular pathogens?
MHC II and CD-4 T-cells
MHC II and CD-8 T-cells
MHC I and CD-4 T-cells
MHC I and CD-8 T-cells

A

MHC II and CD-4 T-cells

22
Q

What protein acts as the signalling domain for the B-cell receptor?
Notch
CD-3
TLR-4
Ig alpha and beta

A

Ig alpha and beta

23
Q

How many different kinds of protein chains make up an antibody structure?
Four
Three
Two
One

24
Q

What isotype of antibody is most important in mucosal defenses?
IgE
IgM
IgD
IgA

25
Q

Which of the following is NOT a granulocyte?
Basophil
Eosinophil
Mast cell
Lymphocyte

A

Lymphocyte

26
Q

What happens to T-cells during developement if they bind too tightly to MHC antigens?
Negative selection
Death by neglect
Positive selection
Activation

A

Negative selection

27
Q

What cells do the final quality control checks on T-cells in the medulla?
Dendritic cells
AIRE
cTEC
Macrophage

28
Q

Where do T-cells complete their development?
Thallamus
Thyroid
Bone marrow
Thymus

29
Q

What is the progression of steps in T-cell development?
DN –> DP –> SP
DP –> DN –> SP
DP –> SP –> DN
DN –> SP –> DP

A

DN –> DP –> SP

30
Q

What enzyme is most important for somatic recombination of T-cell receptors?
Notch
AID
RAG-1
TdT

31
Q

How many ways can a T-cell attempt to make a functional Beta chain?
One
Two
Four
Six

32
Q

Elimination of self-reactive T-cell during development is an important part of ____.
Allergic responses
Peripheral tolerance
The blood-brain barrier
Central tolerance

A

Central tolerance

33
Q

What protein acts as the signalling domain for the T-cell receptor?
CD-8
TLR-4
CD-4
CD-3

34
Q

What happens to T-cells during development if they do not bind at all to MHC antigens?
Death by neglect
Activation
Negative selection
Positive selection

A

Death by neglect

35
Q

What is the most important transcription factor for T-cell development?
NFkB
Notch
Hedgehog
FOX-1

36
Q

Which of the following can arise from both the lymphoid and myeloid cell lines?
B-cells
Neutrophils
T-cells
Dendridic cells

A

Dendridic cells

37
Q

Which of these is true of our innate immunity?
Is non-specific
Has a memory of past infections
Involves antibodies
Takes 10 days to get started

A

Is non-specific

38
Q

What part of our immune defenses is involved in making antibodies?
Complement
Cellular immunity
Humoral immunity
Innate immunity

A

Humoral immunity

39
Q

What cells of the innate immune response eliminate virally infected host cells?
Cytotoxic T-cells
Helper T-cells
NK cells
Neutrophils

40
Q

Which of these would represent an intracellular pathogen?
Staphylococci
Virus
Amoeba
Fungi

41
Q

RIG-1 is a cytosolic receptor that binds to what?
Viral DNA
Viral proteins
Viral lipids
Viral RNA

42
Q

Which of these is the most important transciption factor for responding to LPS?
NFkB
Notch
RAG-1
HIS-2

43
Q

IL-1 is activated by the action of what protein?
Caspase-1
Caspase-9
IL-1
TLR-4

44
Q

Which of these cytokines is secreted in response to viral infection?
IL-4
TNF
IL-1
Interferon

A

Interferon

45
Q

What is our immune system’s first line of defense?
Skin
Neutrophils
Complement
Antibodies

46
Q

What process is responsible for most of the diversity in antibody structure?
Somatic recombination
N nucleotide addition
Somatic hypermutation
P nucleotide addition

A

Somatic recombination

47
Q

What chains make up MOST of our T-cell receptors?
Alpha and Beta
Gamma and Delta
Alpha and Gamma
Beta and Delta

A

Alpha and Beta

48
Q

What part of our immune defenses are B-cell associated with?
Cell-mediated
None of these
Humoral
Innate

49
Q

Which of these is NOT a common function of antibodies?
Direct killing of pathogens
Opsonization
Neutralization
Agglutination

A

Direct killing of pathogens

50
Q

Which of these is involved in antigen presentation of intracellular pathogens?
MHC I and CD-4 T-cells
MHC II and CD-4 T-cells
MHC I and CD-8 T-cells
MHC II and CD-8 T-cells

A

MHC I and CD-8 T-cells

Immunology Quiz Questions (15 decks)

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