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Immunology Quiz Questions > Exam 1 MC > Flashcards

Exam 1 MC Flashcards

1
Q

Which of these would represent an intracellular pathogen?
Helminth
Protozoa
Bacterium
Virus

A

Virus

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2
Q

Which of the following is an agranulocyte?
Eosinophil
Lymphocyte
Basophil
Mast cell

A

Lymphocyte

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3
Q

Which of these is NOT a secondary lymphoid tissue?
Lymph node
Peyers patch
Thymus
Spleen

A

Thymus

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4
Q

Which of these is famous for creating the first vaccine for rabies?
Pasteur
Jenner
Koch
Bassi

A

Pasteur

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5
Q

During an immune response, B-cells differentiate into what?
Granulocytes
Killer cells
Plasma cells
Cytotoxic cells

A

Plasma cells

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6
Q

Which of these cell types can arise from both myeloid and lymphoid precursors?
B-cell
Neutrophil
Basophil
Dendritic cell

A

Dendritic cell

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7
Q

What term refers to a state of being resistant to infection by a pathogen?
Allergy
Tolerance
Carrier
Immunity

A

Immunity

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8
Q

Which of the following is not a chemical barrier in our immune defenses?
Lysozyme
Defensins
Lactic acid
Antibodies

A

Antibodies

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9
Q

The inactivation of the immune response to self antigens is called what?
Hyposensitivity
Tolerance
Hypersensitivity
Allergy

A

Tolerance

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10
Q

RIG-1 is a cytosolic receptor that binds to what?
Viral RNA
Viral proteins
Viral DNA
Viral lipids

A

Viral RNA

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11
Q

What is our immune system’s first line of defense?
Neutrophils
Skin
Antibodies
Complement

A

Skin

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12
Q

What term refers to the process where neutrophils leave circulation and enter tissues?
Apoptosis
Phototaxis
Diapedesis
Viropexis

A

Diapedesis

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13
Q

Which of these is recognized by Toll-like receptor 4 (TLR-4)?
Bacterial DNA
Lipopolysaccharide
Double stranded RNA
Flagellin

A

Lipopolysaccharide

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14
Q

Which of the following is NOT a proinflammatory cytokine?
TNFα
IL-1
IL-6
Interferon

A

Interferon

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15
Q

Which of these is true of Toll-like receptors?
Are formed by somatic recombination
Recognize pathogen-associated patterns
Bind to specific antigens
Active the complement cascade

A

Recognize pathogen-associated patterns

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16
Q

Which protein must be degraded to allow signaling by Toll-like receptors to the nucleus?
NF-κB
IκB
MEK
MyD88

A

IκB

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17
Q

Which of these is NOT typical for an inflammatory response?
Coolness
Redness
Swelling
Pain

A

Coolness

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18
Q

Defective neutrophil clearance can result in chronic inflammation and the formation of what?
Tumor
Granuloma
Allergy
Eschar

A

Granuloma

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19
Q

What is the function of DAF in the complement cascade?
Stabilize C5 convertase
Degrade C5 convertase
Stabilize C3 convertase
Degrade C3 convertase

A

Degrade C3 convertase

20
Q

Which of the complement cascades acts the fastest?
They all act at the same rate
Alternative
Lectin-binding
Classical

A

Alternative

21
Q

Which complement protein forms the pore in the membrane attack complex?
C6
C7
C8
C9

A

C9

22
Q

Which of these is NOT an important function of the complement cascade?
Opsonize pathogens
Directly kill pathogens
Active apoptosis of infected cells
Act as a chemoattractant for phagocytes

A

Active apoptosis of infected cells

23
Q

What is the function of properdin in the complement cascade?
Stabilize C5 convertase
Degrade C5 convertase
Stabilize C3 convertase
Degrade C3 convertase

A

Stabilize C3 convertase

24
Q

Which of these is the C3 convertase in the MBL complement cascade?
C3bBbP
C2b4b
C2b4b3b
C3P0

A

C2b4b

25
Q

What is the function of α2-macroglobulin in our serum?
Cleave C3
Sequester proteases
Initiate blood clotting
Carry oxygen

A

Sequester proteases

26
Q

Which of these proteins is only active in the alternative complement cascade?
C1
C2
Factor B
MASP

A

Factor B

27
Q

Which proteins in the MBL complement cascade perform the same function as C1q2r2 in the classical pathway?
Factor B
Factor D
MASP
C1INH

A

MASP

28
Q

What part of our immune defenses are B-cell associated with?
Cell-mediated
Humoral
Innate
None of these

A

Humoral

29
Q

What process is responsible for most of the diversity in antibody structure?
Somatic recombination
Somatic hypermutation
N nucleotide addition
P nucleotide addition

A

Somatic recombination

30
Q

What chains make up MOST of our T-cell receptors?
Alpha and Beta
Alpha and Gamma
Gamma and Delta
Beta and Delta

A

Alpha and Beta

31
Q

What protein sends a signal via phosphorylation when T-cells are activated?
Igα/β
CD-3
CD-4
CD-8

A

CD-3

32
Q

What proteins would be found on the surface of a helper T-cell?
T-cell receptor and CD4
T-cell receptor and CD8
CD4 and CD8
T-cell receptor, CD4, and CD8

A

T-cell receptor and CD4
(I think)

33
Q

What sort of cytokine action is illustrated to the right?
Autocrine
Endocrine
Paracrine
Exocrine

A

Paracrine

34
Q

Antibodies with differing in the antigen binding specificity would be…
Allotypes
Isotypes
Idiotypes
Phenotypes

A

Idiotypes

35
Q

Which of these regions is found in the beta chain of the T-cell receptor, but NOT the alpha chain?
V
D
J
C

A

D

36
Q

What is the most important antibody in our mucosal defenses?
IgA
IgM
IgG
IgD

A

IgA

37
Q

What is the progression of steps in T-cell development?
DN -> DP -> SP
DN -> SP -> DP
DP -> SP -> DN
DP -> DN -> SP

A

DN -> DP -> SP

38
Q

What is the most important transcription factor for T-cell development?
Hedgehod
FOX-1
NF-κB
Notch

A

Notch

39
Q

What happens to T-cells during development if they do not bind at all to MHC antigens?
Death by neglect
Positive selection
Negative selection
Activation

A

Death by neglect

40
Q

Which of these is NOT found in the thymus?
Follicle
Cortex
Medulla
T-cells

A

Follicle

41
Q

As T-cells enter the thymus from the bone marrow, they are…
Double positive
Single positive
Double negative
Effector cells

A

Double negative

42
Q

What happens to T-cells during development if they bind very tightly to MHC antigens?
Death by neglect
Positive selection
Negative selection
Activation

A

Negative selection

43
Q

In our most common type of T-cells, which chain of their T-cell receptor is made first?
Alpha
Beta
Gamma
Delta

A

Beta

44
Q

What enzyme is critical for the process of somatic recombination?
TδT
Reverse transcriptase
RAG 1/2
RNA polymerase

A

RAG 1/2

45
Q

What cell type does the final screening of newly formed T-cells in the medulla before they are released to circulation?
cTEC
AIRE
Neutrophil
Hassall’s corpuscles

A

AIRE

Immunology Quiz Questions (15 decks)

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