Exam 3 Quizlet questions

Question 1

The production of IgM is mostly associated with the _______ immune response.

Answer 1

primary

Question 2

Pathogen-associated molecular patterns are generally recognized by _______ receptors.

Answer 2

germ-line encoded

Question 3

Which of the following are NOT derived from the myeloid progenitor cells?

Answer 3

plasma cell

Question 4

Which transcription factor is most important for choosing whether to become a B- or T-cell?

Answer 4

Notch

Question 5

Which portion of a lymph node would most likely contain antibody producing cells?

Answer 5

medulla

Question 6

Which of these antibodies has the largest Fc domain?

Answer 6

IgM

Question 7

When IL-2 is produced by a T-cell and simulates that same cell, it is functioning as ______ action.

Answer 7

Autocrine

Question 8

Which of the following receptors contain seven transmembrane helices?

Answer 8

Chemokine

Question 9

Which of these is true of aspirin’s action?

Answer 9

It inhibits both COX-1 and COX-2

Question 10

What does integrin bind to during the extravasation of activated neutrophils?

Answer 10

ICAM

Question 11

Which of the following proteins binds to viral ssRNA during infections?

Answer 11

TLR-7

Question 12

Where are you most likely to find diversification (D) exons?

Answer 12

heavy chain antibody locus

Question 13

Which of these pairs of cell undergo negative selection during B-cell development?

Answer 13

immature B-cell and T1 cells

Question 14

What happens if an immune cell receives only signal one (second signal is absent)?

Answer 14

Anergy

Question 15

Toxic shock syndrome toxin is an example of ______________.

Answer 15

a superantigen

Question 16

Which set of T-cells is most involved with immunity to worm infections?

Answer 16

TH2

Question 17

Protein-based antigens usually stimulate ________ immune response.

Answer 17

T-dependent

Question 18

Where would you find the most B-1 B-cells in a body?

Answer 18

Peritoneum

Question 19

Which antibody isotype can cross the placenta during pregnancy?

Answer 19

IgG

Question 20

Which of the following receptors plays a role in inhibiting immune activation?

Answer 20

FcγRIIB

Question 21

Which Fc receptor is often expressed by epithelial cells to transport antibodies?

Answer 21

PolyIgR

Question 22

What molecules are found on the surface of all cytotoxic lymphocytes?

Answer 22

CD8 and CD40L

Question 23

Proteins called _______ form pores in target cells when released from cytotoxic T-cells.

Answer 23

Perforins

Question 24

The first host response following a viral infection is _________.

Answer 24

An increase in interferon concentrations

Question 25

Which of the following situations would favor cell killing by NK cells?

Answer 25

Loss of MHC class I expression and increased stress protein production

Question 26

Which of the following does NOT form memory cells?

Answer 26

NKT cells

Question 27

Which of the following cytokines is most tolerogenic?

Answer 27

IL-10

Question 28

Most of the migrating lymphocytes in the GALT are found in __________.

Answer 28

lamina propria

Question 29

Which gut cells are most involved in worm defenses?

Answer 29

tuft cells

Question 30

Mucous production in the gut is mediated by ___________.

Answer 30

goblet cells

Question 31

B-cells in Peyer's patches often __________.

Answer 31

class switch to produce IgA antibodies

Question 32

T-dependent IgA production involves the action of __________.

Answer 32

APRIL

Question 33

Which of these conditions is more common in the small intestine?

Answer 33

celiac disease

Question 34

Which of the following bacteria most promote proper immune homeostasis in the gut?

Answer 34

bacteroides fragilis

Question 35

A type 2 response in the gut occurs most commonly with _________ infections.

Answer 35

worm

Question 36

Initial adhesion of naïve lymphocytes in high endothelial venules involves _______.

Answer 36

L-Selectin

Question 37

In the spleen, lymphocytes enter directly into the ___________.

Answer 37

marginal sinus

Question 38

Lymphocytes in lymph nodes browse for antigens on ___________.

Answer 38

reticular network

Question 39

If lymphocytes fail to find a matching antigen in a lymph node, they upregulate the production of ____.

Answer 39

S1P1 receptor

Question 40

What antibody isotype is involved in class I hypersensitivities?

Answer 40

IgE

Question 41

Antihistamines block which histamine receptor?

Answer 41

H1

Question 42

Which type of hypersensitivity does NOT involve the direct action of antibodies?

Answer 42

Type IV

Question 43

Rh hemolytic disease is an example of what type of hypersensitivity?

Answer 43

Type II

Question 44

Which of the following does NOT occur during a type I hypersensitivity reaction?

Answer 44

Bronchiodialation

Question 45

An arthus reaction is an example of what sort of hypersensitivity?

Answer 45

type III

Question 46

The tuberculin skin test is an example of a _________ hypersensitive response.

Answer 46

type IV

Question 47

Poison ivy reactions are due to the plant's production of ____________.

Answer 47

urushoil

Question 48

The incorporation of _ into vaccines helps to elicit an inflammatory response. -complement -adjuvants -cytokines -DNA

Answer 48

adjuvants

Question 49

Which is the first class of immunoglobulin secreted by plasma cells during the primary response? -IgG -IgA -IgE -IgM

Answer 49

IgM

Question 50

The Pfizer/BioNTech and Moderna vaccines against SARS-CoV-2, the causative agent of COVID-19, are _ vaccines. -mRNA -viral DNA -live virus -viral protein

Answer 50

mRNA

Question 51

The most common immunoglobulin produced by plasma cells in the lamina propria is -IgM. -IgA. -IgE. -IgG.

Answer 51

IgA

Question 52

Antibodies are important for protection during -mucosal immunity only. -systemic immunity only. -both systemic and mucosal immunity. -cell-mediated immunity only.

Answer 52

both systematic and mucosal immunity

Question 53

The main function of the MALT is to -connect the lymphatic and circulatory systems. -induce an inflammatory response at mucosal surfaces. -centralize activation of an adaptive immune response at mucosal surfaces. -centralize activation of an innate immune response at mucosal surfaces.

Answer 53

centralize activation of an adaptive immune response at mucosal surfaces

Question 54

What role does the normal microbiota play in protecting mucosal surfaces? -It competes with pathogens for vitamins produced by epithelial cells of MALT. -It competes with pathogens for space and nutrients. -It breaks down antimicrobial products produced by epithelial cells of MALT. -It produces organic molecules that MALT uses for energy.

Answer 54

It competes with pathogens for space and nutrients

Question 55

Which of the following represents the correct sequence of events during a mucosal immune response? -Pathogen infection > pathogen delivery to lamina propria > inflammatory response > pathogen destruction and clearance -Pathogen infection > macrophage activation > inflammatory response > pathogen destruction in lamina propria -Pathogen infection > dendritic cell activation > inflammatory response > pathogen destruction and clearance -Pathogen infection > pathogen delivery to lamina propria > pathogen destruction in lamina propria > healthy mucosal tissue

Answer 55

Pathogen infection > pathogen delivery to lamina propria > pathogen destruction in lamina propria > healthy mucosal tissue

Question 56

Intestinal macrophages, gut dendritic cells, and innate lymphoid cells function in the innate immune response to combat mucosal infection without inducing -cytokines. -the adaptive immune response. -the typical inflammatory response. -mucus.

Answer 56

the typical inflammatory response