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Immunology Quiz Questions > Exam 3 Quizlet questions > Flashcards

Exam 3 Quizlet questions Flashcards

1
Q

The production of IgM is mostly associated with the _______ immune response.

A

primary

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2
Q

Pathogen-associated molecular patterns are generally recognized by _______ receptors.

A

germ-line encoded

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3
Q

Which of the following are NOT derived from the myeloid progenitor cells?

A

plasma cell

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4
Q

Which transcription factor is most important for choosing whether to become a B- or T-cell?

A

Notch

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5
Q

Which portion of a lymph node would most likely contain antibody producing cells?

A

medulla

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6
Q

Which of these antibodies has the largest Fc domain?

A

IgM

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7
Q

When IL-2 is produced by a T-cell and simulates that same cell, it is functioning as ______ action.

A

Autocrine

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8
Q

Which of the following receptors contain seven transmembrane helices?

A

Chemokine

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9
Q

Which of these is true of aspirin’s action?

A

It inhibits both COX-1 and COX-2

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10
Q

What does integrin bind to during the extravasation of activated neutrophils?

A

ICAM

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11
Q

Which of the following proteins binds to viral ssRNA during infections?

A

TLR-7

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12
Q

Where are you most likely to find diversification (D) exons?

A

heavy chain antibody locus

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13
Q

Which of these pairs of cell undergo negative selection during B-cell development?

A

immature B-cell and T1 cells

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14
Q

What happens if an immune cell receives only signal one (second signal is absent)?

A

Anergy

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15
Q

Toxic shock syndrome toxin is an example of ______________.

A

a superantigen

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16
Q

Which set of T-cells is most involved with immunity to worm infections?

A

TH2

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17
Q

Protein-based antigens usually stimulate ________ immune response.

A

T-dependent

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18
Q

Where would you find the most B-1 B-cells in a body?

A

Peritoneum

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19
Q

Which antibody isotype can cross the placenta during pregnancy?

A

IgG

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20
Q

Which of the following receptors plays a role in inhibiting immune activation?

A

FcγRIIB

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21
Q

Which Fc receptor is often expressed by epithelial cells to transport antibodies?

A

PolyIgR

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22
Q

What molecules are found on the surface of all cytotoxic lymphocytes?

A

CD8 and CD40L

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23
Q

Proteins called _______ form pores in target cells when released from cytotoxic T-cells.

A

Perforins

24
Q

The first host response following a viral infection is _________.

A

An increase in interferon concentrations

25
Q

Which of the following situations would favor cell killing by NK cells?

A

Loss of MHC class I expression and increased stress protein production

26
Q

Which of the following does NOT form memory cells?

A

NKT cells

27
Q

Which of the following cytokines is most tolerogenic?

A

IL-10

28
Q

Most of the migrating lymphocytes in the GALT are found in __________.

A

lamina propria

29
Q

Which gut cells are most involved in worm defenses?

A

tuft cells

30
Q

Mucous production in the gut is mediated by ___________.

A

goblet cells

31
Q

B-cells in Peyer’s patches often __________.

A

class switch to produce IgA antibodies

32
Q

T-dependent IgA production involves the action of __________.

A

APRIL

33
Q

Which of these conditions is more common in the small intestine?

A

celiac disease

34
Q

Which of the following bacteria most promote proper immune homeostasis in the gut?

A

bacteroides fragilis

35
Q

A type 2 response in the gut occurs most commonly with _________ infections.

A

worm

36
Q

Initial adhesion of naïve lymphocytes in high endothelial venules involves _______.

A

L-Selectin

37
Q

In the spleen, lymphocytes enter directly into the ___________.

A

marginal sinus

38
Q

Lymphocytes in lymph nodes browse for antigens on ___________.

A

reticular network

39
Q

If lymphocytes fail to find a matching antigen in a lymph node, they upregulate the production of ____.

A

S1P1 receptor

40
Q

What antibody isotype is involved in class I hypersensitivities?

A

IgE

41
Q

Antihistamines block which histamine receptor?

A

H1

42
Q

Which type of hypersensitivity does NOT involve the direct action of antibodies?

A

Type IV

43
Q

Rh hemolytic disease is an example of what type of hypersensitivity?

A

Type II

44
Q

Which of the following does NOT occur during a type I hypersensitivity reaction?

A

Bronchiodialation

45
Q

An arthus reaction is an example of what sort of hypersensitivity?

A

type III

46
Q

The tuberculin skin test is an example of a _________ hypersensitive response.

A

type IV

47
Q

Poison ivy reactions are due to the plant’s production of ____________.

A

urushoil

48
Q

The incorporation of _ into vaccines helps to elicit an inflammatory response.
-complement
-adjuvants
-cytokines
-DNA

A

adjuvants

49
Q

Which is the first class of immunoglobulin secreted by plasma cells during the primary response?
-IgG
-IgA
-IgE
-IgM

A

IgM

50
Q

The Pfizer/BioNTech and Moderna vaccines against SARS-CoV-2, the causative agent of COVID-19, are _ vaccines.
-mRNA
-viral DNA
-live virus
-viral protein

A

mRNA

51
Q

The most common immunoglobulin produced by plasma cells in the lamina propria is
-IgM.
-IgA.
-IgE.
-IgG.

A

IgA

52
Q

Antibodies are important for protection during
-mucosal immunity only.
-systemic immunity only.
-both systemic and mucosal immunity.
-cell-mediated immunity only.

A

both systematic and mucosal immunity

53
Q

The main function of the MALT is to
-connect the lymphatic and circulatory systems.
-induce an inflammatory response at mucosal surfaces.
-centralize activation of an adaptive immune response at mucosal surfaces.
-centralize activation of an innate immune response at mucosal surfaces.

A

centralize activation of an adaptive immune response at mucosal surfaces

54
Q

What role does the normal microbiota play in protecting mucosal surfaces?
-It competes with pathogens for vitamins produced by epithelial cells of MALT.
-It competes with pathogens for space and nutrients.
-It breaks down antimicrobial products produced by epithelial cells of MALT.
-It produces organic molecules that MALT uses for energy.

A

It competes with pathogens for space and nutrients

55
Q

Which of the following represents the correct sequence of events during a mucosal immune response?
-Pathogen infection > pathogen delivery to lamina propria > inflammatory response > pathogen destruction and clearance
-Pathogen infection > macrophage activation > inflammatory response > pathogen destruction in lamina propria
-Pathogen infection > dendritic cell activation > inflammatory response > pathogen destruction and clearance
-Pathogen infection > pathogen delivery to lamina propria > pathogen destruction in lamina propria > healthy mucosal tissue

A

Pathogen infection > pathogen delivery to lamina propria > pathogen destruction in lamina propria > healthy mucosal tissue

56
Q

Intestinal macrophages, gut dendritic cells, and innate lymphoid cells function in the innate immune response to combat mucosal infection without inducing
-cytokines.
-the adaptive immune response.
-the typical inflammatory response.
-mucus.

A

the typical inflammatory response

Immunology Quiz Questions (15 decks)

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