Exam 1 Quizlet questions Flashcards
Who discovered that silkworm disease can be caused by a fungus?
Bassi
Who developed a vaccine for smallpox?
jenner
What part of our immune defenses is involved in making antibodies?
humoral
What cells of the innate immune response eliminate virally infected host cells?
Natural Killer Cells
Which of these is true of our innate immunity?
it is non-specific
Which of these is NOT true of the innate immune system?
It takes 7 to 10 days to begin a response
Which of these cytokines is secreted in response to viral infection?
Interferon
IL-1 is activated by the action of what protein?
Capase 1
What type of action do most cytokines produce?
Paracrine
During the oxidative burst, what reactive oxygen species is produced by NADPH oxidase?
Superoxide
Which of these is the most important transciption factor for responding to LPS?
NFkB
Which of these is the C3 convertase of the alternative cascade?
C3bBbP
Which of these is the C5 convertase of the classical cascade?
C2b4b3b
Which complement cascade involves the action of MASPs?
Alternative
What is the main anaphylatoxin produced in the complement cascade?
C5a
What is the main opsin in the complement cascade?
C3b
Which of these is NOT a common function of antibodies?
direct killing of pathogens
Which of these is involved in antigen presentation of extracellular pathogens?
MHC II and CD-4 T-cells
Which of these is involved in antigen presentation of intracellular pathogens?
MHC I and CD-8 T-cells
What protein acts as the signalling domain for the B-cell receptor?
Ig alpha and beta
What protein acts as the signaling domain for the T-cell receptor?
CD-3
Elimination of self-reactive T-cell during development is an important part of ____.
central tolerance
Which of the following people created the first vaccines for anthrax and rabies?
a. Metchnikoff
b. Fleming
c. Jenner
d. Pasteur
Pasteur
What is the only human disease to be eradicated by immunization?
a. Rabies
b. Polio
c. Smallpox
d. Measels
smallpox
With what part of the immune system are Peyer’s patches associated?
a. Spleen
b. Thymus
c. Lymph nodes
d. GALT
GALT
Which of the following us true of the COX1 enzyme, but not COX2?
a. It is involved in blood clotting
b. It is inhibited by steroids
c. It is inhibited by aspirin
d. It is induced during infections
it is involved in blood clotting
Which is true of the secondary immune response?
a. Mostly IgM is produced
b. Antibodies of low affinity are produced
c. Prior exposure to the antigen is required
d. It produces no lasting immunological memory
prior exposure to the antigen is required
What is the most numerous white blood cell in the peripheral circulation?
a. Erythrocyte
b. Eosinophil
c. Neutrophil
d. Lymphocyte
neutrophil
Which of the following cells is part of the innate immune defense?
a. Plasma cell
b. Macrophage
c. Memory cell
d. T-cell
macrophage
Which of these proteins is created through genetic rearrangements of gene segments?
a. Fc Receptor
b. Chemokine receptor
c. Il-1 receptor
d. T-cell receptor
T-cell receptor
Which of these is NOT an important antigen presenting cell?
a. T-cell
b. Neutrophil
c. Macrophage
d. Dendritic cell
T-cell
Which of these proteins does NOT contain multiple immunoglobulin folding domains?
a. Antibody
b. T-cell Receptor
c. Chemokine receptor
d. MHC class II molecule
Chemokine receptor
What process is involved in expanding populations of useful lymphocytes during the immune response to a pathogen?
a. Clonal deletion
b. Clonal selection
c. Isotype switching
d. Apoptosis
clonal selection
What organ is most responsible for clearing old blood cells and antigen-antibody complexes?
a. Thymus
b. Bone marrow
c. Kidneys
d. Spleen
spleen
What sort of ligands are recognized by TLR, CLR, NLR and RLR?
a. Cytokines
b. Chemokines
c. Pathogen-associated patterns
d. Antigens on presenting cells
pathogen associated patterns
Which of the following is a quality of an excellent antigen?
a. Small size
b. Similarity to host tissues
c. Chemical complexity
d. Presentation on foreign MHC molecule
chemical complexity
What is the most potent chemoattractant produced in the complement system?
a. C1qrs
b. C6
c. C3b
d. C5a
C5a
Neutrophils are formed in the ________________precursor cell line.
Myeloid
IgA, IgG, and IgD are different ___________ of antibodies.
Isotypes
A protein found on our skin called _____________kills Escherichia coli on contact.
Psoriasin
The complement cascade can kill pathogens by forming a pore called ________________.
MAC
